Treatment Effects in Randomized and Nonrandomized Studies of Pharmacological Interventions
Maximilian Salcher-Konrad,
Mary Nguyen,
Jelena Savović
et al.
Abstract:ImportanceRandomized clinical trials (RCTs) are widely regarded as the methodological benchmark for assessing clinical efficacy and safety of health interventions. There is growing interest in using nonrandomized studies to assess efficacy and safety of new drugs.ObjectiveTo determine how treatment effects for the same drug compare when evaluated in nonrandomized vs randomized studies.Data SourcesMeta-analyses published between 2009 and 2018 were identified in MEDLINE via PubMed and the Cochrane Database of Sy… Show more
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