Treatment effects and periodontal status of chronic periodontitis after routine Er:YAG laser-assisted therapy

Gao, Yong-Zhi; Li, Yan; Chen, Shanshan; Bo, Feng; Wang, Hui; Wang, Qiao

doi:10.12998/wjcc.v9.i32.9762

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…Recent epidemiological surveys show that more than half of adults worldwide suffer from gingivitis and periodontitis, with a trend toward younger adults [ 27 ]. Clinically, the main goal of periodontitis treatment is to inhibit plaque and eliminate inflammation to prevent deterioration and recurrence of the disease [ 28 ]. Given the potential for directed differentiation of MSCs, using gingiva MSCs was expected to be an effective solution for the radical treatment of periodontitis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Wang

Zheng²,

Wei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the molecular mechanisms of microRNA-146a (miR-146a) on gingival mesenchymal stem cells (MSCs). Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation. miR-146a inhibits osteoblast differentiation by inhibiting phosphorylated cyclic-AMP response binding (CREB) protein translocation into the nucleus and ultimately attenuating runt-related transcription factor 2 (Runx2) expression. Furthermore, silencing miR-146a promotes the proliferation of gingival MSCs. Of note, targeted inhibition of miR-146a also inhibited LPS-induced inflammatory response and promoted the proliferation of gingival MSCs via CREB/Runx2 axis. MiR-146a is a key negative regulator of gingival MSCs proliferation and osteogenic differentiation, and targeting to reduce the miR-146a expression is essential for bone formation signaling. Therefore, we propose that miR-146a is a useful therapeutic target for the development of bone anabolic strategies.

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Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Wang

Zheng²,

Wei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…On the other hand, the laser main energy density is delivered laterally, keeping the deepest sulcus attachment moderately impacted by laser irradiation. It was also mentioned by Gao et al in 2021 that low energy levels delivered from the Er:YAG laser during root irradiation have no irreversible damage on periodontal tissues; on the contrary, it improves overall healing by reducing inflammatory factors and colony forming units [32]. Meanwhile, Yaneva et al in 2016 demonstrated the innocuity of pulp tissue to the energy level (100 mJ, 50 Hz, and 40 s irradiation time) higher than the ones used in our study [33].…”

Section: Discussionmentioning

confidence: 95%

Assessment of the Periodontal Cementum Ablation Depth during Root Planing by an Er:YAG Laser at Different Energy Densities: An Ex Vivo Study

et al. 2023

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Introduction: An important and non-adapted delivered energy of Er:YAG laser can eliminate the total thickness of root cementum during root planing. Conversely, the preservation of a partial layer of cementum covering the roots is vital for any periodontal ligament regeneration. Thus, the assessment of the cementum ablation depth produced by each energy density of Er:YAG laser is essential before considering its use for the periodontal planing and treatment of the cementum and root surfaces. Aim of the study: Assessment of the cementum ablation depth at different energy densities of the Er:YAG laser is the aim of this study. Materials and methods: A total of 48 human caries free molars were collected and used in this study. Areas to be irradiated were delimited by two longitudinal grooves (0.5 mm depth). Roots were divided randomly into four groups (4 × n = 12). An Er:YAG laser (2.94 µm) was used with a side-firing tip (R600T) with a 600 µm diameter and a frequency of 20 Hz combined with a cooling system of air 6 mL/min and water 4 mL/min. We used a super short pulse mode (SSP: pulse duration: 50 μs). We used a single irradiation passage backward from apex to cervical parts at 1 mm/s with a slight contact and at an angle of 15° to 30° between the tip and the root surface. Different energies were selected: 30 mJ, 40 mJ, 50 mJ, and 60 mJ. Results: Microscopic observations showed that the average of the ablation depth increased with the increase of the delivered energy from 30 mJ to 60 mJ. Mean values of the ablation depths were respectively as follows: 43.75 ± 4.89 µm for the energy of 30 mJ, 50.05 ± 3.72 µm for 40 mJ, 65.56 ± 10.35 µm for 50 mJ, and 74.80 ± 15.23 µm for 60 mJ. A statistically significant difference existed between the ablation depth of all groups. Conclusion: Based on our results, the depth of cementum debridement is related to the level of the delivered energy. The lowest energy levels (30 mJ and 40 mJ) can ablate the root cementum surface for a variable depth from 43.75 ± 4.89 μm to 50.05 ± 3.72 μm.

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“…For supragingival calculus, three treatment studies were included from a total of 197 articles. This includes one clinical practice guideline and two randomized controlled trials (RCTs) ( Supplementary Table S2 ) [ 12 , 13 , 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…AI produced similar treatment options, emphasizing the use of scalers to remove supragingival calculus [ 17 , 18 ]. Bard cited the EFP guidelines as the basis of their recommendations, denoting a commonality between the rapid review and AI [ 14 ]. However, variation existed in their recommendations for adjunctive treatment and risk factor management compared to the rapid review [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Treatment Recommendations by Pragmatic Evidence Search and Artificial Intelligence: An Exploratory Study

Baig,

Lawrence,

Ganhewa

et al. 2024

Diagnostics

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There is extensive literature emerging in the field of dentistry with the aim to optimize clinical practice. Evidence-based guidelines (EBGs) are designed to collate diagnostic criteria and clinical treatment for a range of conditions based on high-quality evidence. Recently, advancements in Artificial Intelligence (AI) have instigated further queries into its applicability and integration into dentistry. Hence, the aim of this study was to develop a model that can be used to assess the accuracy of treatment recommendations for dental conditions generated by individual clinicians and the outcomes of AI outputs. For this pilot study, a Delphi panel of six experts led by CoTreat AI provided the definition and developed evidence-based recommendations for subgingival and supragingival calculus. For the rapid review—a pragmatic approach that aims to rapidly assess the evidence base using a systematic methodology—the Ovid Medline database was searched for subgingival and supragingival calculus. Studies were selected and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and this study complied with the minimum requirements for completing a restricted systematic review. Treatment recommendations were also searched for these same conditions in ChatGPT (version 3.5 and 4) and Bard (now Gemini). Adherence to the recommendations of the standard was assessed using qualitative content analysis and agreement scores for interrater reliability. Treatment recommendations by AI programs generally aligned with the current literature, with an agreement of up to 75%, although data sources were not provided by these tools, except for Bard. The clinician’s rapid review results suggested several procedures that may increase the likelihood of overtreatment, as did GPT4. In terms of overall accuracy, GPT4 outperformed all other tools, including rapid review (Cohen’s kappa 0.42 vs. 0.28). In summary, this study provides preliminary observations for the suitability of different evidence-generating methods to inform clinical dental practice.

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Treatment effects and periodontal status of chronic periodontitis after routine Er:YAG laser-assisted therapy

Cited by 5 publications

References 18 publications

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Assessment of the Periodontal Cementum Ablation Depth during Root Planing by an Er:YAG Laser at Different Energy Densities: An Ex Vivo Study

Accuracy of Treatment Recommendations by Pragmatic Evidence Search and Artificial Intelligence: An Exploratory Study

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