Treatment data using a topical povidone-iodine antiseptic in patients with superficial skin abscesses

Schmitz, Gillian; Rosenblatt, Lauren; Salerno, N.; Odette, Julie; Ren, Ronnie; Emanuel, Tatiana; Michalek, Joel E.; Qianqian, Liu; Du, Liem C.; Jahangir, K.; Olson, Adriana Segura

doi:10.1016/j.dib.2019.103715

Cited by 10 publications

(27 citation statements)

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“…Iodine can play a positive role as microbicidal coating but disadvantages like skin irritation, discoloration and short durability by uncontrolled free iodine release are drawbacks [26,30]. The commonly used disinfectant povidone iodine is reported to have similar adverse effects and incorporates triiodide ions for the release of free iodine [48][49][50]. Silver nanoparticles have antimicrobial effects and are incorporated increasingly in many products, including surgical sutures [58,59].…”

Section: Discussionmentioning

confidence: 99%

“…Reducing the AgNP content will decrease its hazards to human health and environment. The adverse effects related to PI and iodine can be minimized by this potent combination through controlled release of iodine [42,49,50]. The synergism of these compounds reduces the amount of needed PI for optimal microbial growth control and its adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…It was found that 59.6% of the patients in the povidone iodine group reported adverse effects compared to 26.5% of patients in the standard care group without PI [49]. The adverse effects included burning/pain, pruritis, skin irritation around the wound and skin coloration [49]. These limited results indicate the need to improve PI delivery to the wound site.…”

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confidence: 99%

“…PI is known for its broad-spectrum microbicidal properties and is used in wound care [32,47,48]. A recent paper from Schmitz et al investigated PI in a randomized clinical trial with 101 enrolled patients [49]. It was found that 59.6% of the patients in the povidone iodine group reported adverse effects compared to 26.5% of patients in the standard care group without PI [49].…”

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confidence: 99%

“…A recent paper from Schmitz et al investigated PI in a randomized clinical trial with 101 enrolled patients [49]. It was found that 59.6% of the patients in the povidone iodine group reported adverse effects compared to 26.5% of patients in the standard care group without PI [49]. The adverse effects included burning/pain, pruritis, skin irritation around the wound and skin coloration [49].…”

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confidence: 99%

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“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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Iodinated Aloe Vera Formulations for Antimicrobial and Cosmeceutical Applications

Edis,

Bloukh,

Abusara

et al. 2024

Biomass-Based Cosmetics

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Evaluation of effectiveness of a new treatment method for healing infected wounds: an animal model

et al. 2021

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Objective: To evaluate the effectiveness of a new treatment method in healing superficial infected wounds compared with surgical debridement with chlorhexidine solution. Method: In this animal model, two wounds were created on the back of 10 male adult rabbits. Wounds treated by Method 1 were debrided using 0.02% chlorhexidine aqueous solution and an antibiotic topical ointment. Wounds treated by Method 2 wounds were treated using a newly developed device which enabled visual monitoring of the wound as it was treated with various pharmacological solutions (including antiseptic, antiseptic oxidant and an osmotically active agent) specifically formulated for each wound healing stage. Wound area size (using digital planimetry) and time taken to clean the wound were recorded, and biopsies were taken, at the beginning of the study and at various timepoints throughout. Result: It was observed that both wound cleaning and wound healing were accelerated by treatment with method 2 compared with method 1 (by 43.8% and 36.7%, respectively). There were also a significantly smaller number of complications in these wounds [p=0.0044] due to the positive ratios of neutrophils and fibroblasts in the wound cavities (from the third to the fourteenth day after wound modelling). Conclusion: Wounds treated with the new device in method 2 had a shorter wound healing time than wounds treated with a traditional method. The automated influx–outflow of solutions removed any fragments of necrotic tissue from the wound surface. Wounds were able to be monitored without the need to remove dressings. The transparent, airtight film, which allowed for wound monitoring without the need to remove dressings, meant that suturing was not required. This resulted in no complications in the wounds treated by this new method.

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Treatment data using a topical povidone-iodine antiseptic in patients with superficial skin abscesses

Cited by 10 publications

References 1 publication

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Iodinated Aloe Vera Formulations for Antimicrobial and Cosmeceutical Applications

Evaluation of effectiveness of a new treatment method for healing infected wounds: an animal model

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