Treatment by Plasma Exchange of a Patient with Autoantibodies to the Insulin Receptor

Muggeo, Michele; Js, Flier; Ra, Abrams; Lc, Harrison; Ab, Deisserroth; Kahn, C. Ronald

doi:10.1056/nejm197903013000906

Cited by 59 publications

(9 citation statements)

References 18 publications

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“…Remission of insulin resistance with disappearance of receptor antibodies has been observed. Patients with re fractory severe insulin resistance have been treated with a variety of regi mens, including glucocorticoids, antimetabolites, and plasma exchange (61). These have produced only limited success.…”

Section: Clinical States Of Insulin Resistance With Target Cell Defectsmentioning

confidence: 99%

Insulin Receptors and Insulin Resistance

Flier¹

1983

Annu. Rev. Med.

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Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mecha nism and significance:of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors. In this article, we review our current' understanding of insulin receptors and their regulation, and we assess the role of insulin receptor pathology in the various syndromes characterized by insulin resistance.

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Section: Clinical States Of Insulin Resistance With Target Cell Defectsmentioning

confidence: 99%

Insulin Receptors and Insulin Resistance

Flier¹

1983

Annu. Rev. Med.

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“…In vitro, autoantibodies mimic most, if not all, of insulin's effects and competitively inhibit binding of insulin to its receptor (4 Plasma obtained from four patients who spontaneously developed Anti-R was studied. These patients are referred to as B-1, B-6, B-10, and B-12. Their clinical features may be found in Table I and in previous reports (5)(6)(7)(8)(9)(10). Patients B-6 and B-10 had received insulin previously, but only patient B-10 had detectable anti-insulin antibodies.…”

Section: Introductionmentioning

confidence: 81%

Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats.

Dons¹,

Havlik²,

Taylor³

et al. 1983

J. Clin. Invest.

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“…For the purpose of reducing antibody production, immunosuppressive drugs such as cyclophosphamide, 6-mercaptopurine and prednisone (Kawanishi et al 1979;Flier et al 1979) should be used with caution. Muggeo et al (1979) triedd the treatment by plasma exchange for removing out the antibodies from blood. We had better expect the spontaneous remission which would occur more than half a year after the onset of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%