Treatment by collagen conduit of painful post-traumatic neuromas of the sensitive digital nerve: A retrospective study of 10 cases

Thomsen, Laura H.; Bellemère, P.; Loubersac, T.; Gaisne, E.; Poirier, P.; Chaise, F.

doi:10.1016/j.main.2010.07.004

Cited by 58 publications

(39 citation statements)

References 39 publications

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“…72 Thomsen et al further demonstrated that among 10 clinical cases, only 50% patients had good outcomes as measured by a variety of methods (2-point discrimination, Semmes-Weinstein, Quick-Dash outcome survey, Cold Intolerance Symptom Severity, and pain recurrence testing). 73 Cumulatively, these disappointing results highlight the limitations of hollow lumen conduits, prompting further development of NGCs with more advanced structural designs.…”

Section: Architecturementioning

confidence: 99%

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

et al. 2018

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Peripheral nerve injury is a common disease that affects more than 20 million people in the United States alone and remains a major burden to society. The current gold standard treatment for critical-sized nerve defects is autologous nerve graft transplantation; however, this method is limited in many ways and does not always lead to satisfactory outcomes. The limitations of autografts have prompted investigations into artificial neural scaffolds as replacements, and some neural scaffold devices have progressed to widespread clinical use; scaffold technology overall has yet to be shown to be consistently on a par with or superior to autografts. Recent advances in biomimetic scaffold technologies have opened up many new and exciting opportunities, and novel improvements in material, fabrication technique, scaffold architecture, and lumen surface modifications that better reflect biological anatomy and physiology have independently been shown to benefit overall nerve regeneration. Furthermore, biomimetic features of neural scaffolds have also been shown to work synergistically with other nerve regeneration therapy strategies such as growth factor supplementation, stem cell transplantation, and cell surface glycoengineering. This review summarizes the current state of neural scaffolds, highlights major advances in biomimetic technologies, and discusses future opportunities in the field of peripheral nerve regeneration.

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Section: Architecturementioning

confidence: 99%

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

et al. 2018

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“…22,23 Thomsen et al presented the only data on 10 digital nerve reconstructions with porcine collagen I þ III conduits (Revolnerv, Orthomed, St. Jeannet, France). 24 All six cases with a gap length of 5 to 20 mm and a follow-up of at least 12 months showed static 2PD of 4 to 15 mm.…”

Section: Discussionmentioning

confidence: 78%

Prospective Clinical Study on Digital Nerve Repair with Collagen Nerve Conduits and Review of Literature

Lohmeyer

Kern

Schmauß

et al. 2013

J reconstr Microsurg

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Little data are available concerning conduit repair of digital nerve lesions. We are presenting a prospective two-center cohort study on digital nerve reconstruction with collagen nerve conduits. The data are put into the context of a comprehensive review of existing literature. Over a period of 3 years, all consecutive digital nerve lesions that could not be repaired by tensionless coaptation with a gap length of less than 26 mm were reconstructed with nerve conduits made from bovine collagen I. Sensibility was assessed 1 week, 3, 6, and 12 months postoperatively by static and moving 2-point-discrimination (2PD) and monofilament testing. Forty-nine digital nerve lesions in 40 patients met the inclusion criteria. The mean nerve gap was 12.3 ± 2.3 mm (span 5-25 mm). Forty nerve reconstructions could be included in the 12-month follow-up. Three cases, assessed 12 months postoperatively, showed excellent sensibility (static 2PD <6 mm). Seventeen achieved good (2PD 6-10 mm), 5 fair (2PD 11-15 mm), 6 poor (2PD >15 mm, but protective sensibility), and 9 achieved no sensibility. Monofilament test results were significantly better if gap length was shorter than 12 mm. Our results confirm tubulization as one possible technique in nerve reconstruction for gap lengths of 5 to 25 mm.

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“…Several studies have demonstrated favorable outcome of digital nerve reconstructions using different types of conduits. [7][8][9][10][11][17][18][19][20][21][22] The return of sensibility after nerve reconstruction using collagen I conduits was investigated by Taras et al in 21 nerves. 7 The authors found an m2PD in all patients of at least 8 mm; the mean follow-up was 20 months.…”

Section: Discussionmentioning

confidence: 99%

“…There are several studies on the conduit repair of digital nerve lesions that demonstrate good clinical outcomes. [7][8][9][10][11] Some of these studies have a mean follow-up of 20 to 31 months. However, most authors only present 12-month data.…”

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confidence: 99%

Is Nerve Regeneration after Reconstruction with Collagen Nerve Conduits Terminated after 12 months? The Long-Term Follow-Up of Two Prospective Clinical Studies

Schmauß

Finck

Liodaki

et al. 2014

J reconstr Microsurg

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Treatment by collagen conduit of painful post-traumatic neuromas of the sensitive digital nerve: A retrospective study of 10 cases

Cited by 58 publications

References 39 publications

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration

Prospective Clinical Study on Digital Nerve Repair with Collagen Nerve Conduits and Review of Literature

Is Nerve Regeneration after Reconstruction with Collagen Nerve Conduits Terminated after 12 months? The Long-Term Follow-Up of Two Prospective Clinical Studies

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