Treatment and Vision-Related Quality of Life in the Early Manifest Glaucoma Trial

Hyman, Leslie; Komaroff, Eugene; Heijl, Anders; Bengtsson, Bo; Leske, M. Cristina

doi:10.1016/j.ophtha.2005.03.028

Cited by 151 publications

(118 citation statements)

References 21 publications

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“…However, this difference was very small and the results of probabilistic sensitivity analysis confirmed the insignificance of the difference. In cases of diagnosed early glaucoma, vision-targeted HRQoL have been reported to be similar for treated and untreated patients (Hyman et al 2005). …”

Section: Limitations Of the Studymentioning

confidence: 97%

“…Therefore, we used the same HRQoL score in both progressive and non-progressive cases. Although counterintuitive, this assumption is, at least in early glaucoma, supported by the Early Manifest Glaucoma Trial Group report, in which Hyman et al (2005) found that visual field defect progression did not affect vision-targeted HRQoL until visual acuity was affected or with increase of the mean deviation of the better eye. This pattern is also clear in the HRQoL scores we derived.…”

Section: Limitations Of the Studymentioning

confidence: 99%

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Cost effectiveness and cost utility of an organized screening programme for glaucoma

Vaahtoranta-Lehtonen¹,

Tuulonen²,

Aronen³

et al. 2007

Acta Ophthalmol Scand

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ABSTRACT.Purpose: To assess the cost effectiveness and cost utility of an organized screening programme for glaucoma. The previous cost-effectiveness studies of screening show inconsistent results, and the cost utility of screening has not been assessed. Methods: An organized screening programme was simulated using Markov modelling in a population aged 50-79 years at 5 year intervals. The programme ended when the subjects reached the age of 80 years. The comparator was opportunistic case finding. The main outcome measures were cases and years of severe visual disability avoided, quality-adjusted life years (QALYs) gained and direct healthcare and non-healthcare costs. Results: The incremental cost of 1 year of avoided visual disability by screening was €32 602. The cost of one QALY gained by screening was €9023 with a discount rate of 5%. During the average 20 year time horizon considered, the cumulative incremental costs of screening in a population of 1 million people would be €30 million, producing 3360 incremental QALYs and 930 years of avoided visual disability for 701 persons. The results were sensitive to the estimates of several parameters, especially screening cost and specificity of screening tests (96-99% specificity required). Conclusion: An organized screening programme could be a cost-effective strategy especially in older age groups, in which screening is clearly more likely to be acceptable to decision makers at any level in terms of their willingness to pay for a QALY. Modelling includes some uncertainty especially concerning the specificity of diagnostic tests and screening cost.

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Section: Limitations Of the Studymentioning

confidence: 97%

Section: Limitations Of the Studymentioning

confidence: 99%

Cost effectiveness and cost utility of an organized screening programme for glaucoma

Vaahtoranta-Lehtonen¹,

Tuulonen²,

Aronen³

et al. 2007

Acta Ophthalmol Scand

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“…It has also been shown that interventions which improve visual function, such as cataract surgery, also improve HRQOL [15][16][17][18][19][20]. For persons with permanent visual impairment (i.e.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life following blind rehabilitation

Kuyk

Liu

Elliott³

et al. 2008

Qual Life Res

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Purpose-The purpose of this study was to investigate the effect of residential blind rehabilitation on patients' vision targeted health-related quality of life (HRQOL) and general physical and mental function.Methods-The National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ) plus appendix questions, the 12 item Short-Form Health Survey (SF-12), Hope Scale and Coopersmith self-esteem inventory were administered to 206 legally blind veterans prior to their entering a residential (in-patient) blind rehabilitation program and again to 185 and 176 of the original cohort at two and six months after completion of the rehabilitation program, respectively. Data on visual acuity, visual field extent, contrast sensitivity and scanning ability were also collected. The duration of the in-patient rehabilitation programs ranged from 11-109 days. Questionnaire scores were compared pre-rehabilitation and post-rehabilitation.Results-Following rehabilitation there was a significant improvement in nine of eleven NEI VFQ subscales and in a composite score at both 2-and 6-month post-rehab intervals. Mental health (SF-12) and self esteem also improved significantly although physical health ratings declined over the course of the study (approximately 10 months).Conclusions-Residential blind rehabilitation appears to improve patients' self-reported visiontargeted HRQOL, self-esteem, and mental health aspects of generic HRQOL.

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“…Recognizing ocular hypertension is important because treatment to lower IOP may delay progression of visual field deficits in some asymptomatic individuals with early OAG [12]. The Early Manifest Glaucoma Trial found that immediate treatment of people who have early-stage glaucoma can delay progression of the disease [51]. The Ocular Hypertension Treatment Study found that topical ocular hypotensive medication was effective in delaying or preventing onset of OAG in individuals with elevated IOP [10].…”

Section: Early-stage Glaucomamentioning

confidence: 99%

Diagnostic accuracy of the iCare rebound tonometer compared to the Perkins applanation tonometer in assessing intraocular pressure in rural patients

Carpenter

Nicholson

et al. 2015

Diagnosis

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Background: Vision health is recognized as a critical unmet need in North America. The ocular morbidity associated with glaucoma results from increased intraocular pressure (IOP) and early detection is crucial for the management of glaucoma. Our objective was to find a diagnostically accurate screening tool for intraocular hypertension that can be used in rural communities. We sought to validate the diagnostic accuracy of the iCare rebound tonometer against the gold standard Perkins applanation tonometer (PAT) in measuring IOP. Methods: Patients from two rural communities in Ontario, Canada visiting their optometrists for routine appointments had their IOP measured by a non-contact tonometer (NCT), an iCare rebound tonometer, and a Perkins applanation tonometer (PAT). Values of sensitivity, specificity, and likelihood ratios for a positive and negative result were calculated for the iCare and the NCT. Results: Complete data was collected from 209 patients. Overall, the iCare tonometer had high levels of validity, as

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Treatment and Vision-Related Quality of Life in the Early Manifest Glaucoma Trial

Cited by 151 publications

References 21 publications

Cost effectiveness and cost utility of an organized screening programme for glaucoma

Cost effectiveness and cost utility of an organized screening programme for glaucoma

Health-related quality of life following blind rehabilitation

Diagnostic accuracy of the iCare rebound tonometer compared to the Perkins applanation tonometer in assessing intraocular pressure in rural patients

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