Treatment and survival patterns of Chinese patients diagnosed with breast cancer between 2005 and 2009 in Southwest China

Peng, Zuxiang; Jia, Wei Hua; Lu, Xuesong; Zheng, Hong; Gao, Weiguo; Chen, Yunqin; Jing, Jing

doi:10.1097/md.0000000000003865

Cited by 22 publications

(24 citation statements)

References 21 publications

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“…The patient cohort, data collection, patient baseline characteristics (including age at diagnosis, menopause status, parity, breastfeeding history, treatment history and residential status), classification of tumor and molecular subtypes, and analyses of patient outcomes have previously been described elsewhere [9]. …”

Section: Methodsmentioning

confidence: 99%

“…Cities in China are classified into four tiers, based on size and overall function (i.e., provincial capitals) [9]. Patients were categorized as urban if they lived in any city, regardless of tier, as rural if they lived in places other than cities, and as unknown if no information was recorded.…”

Section: Methodsmentioning

confidence: 99%

“…The data described previously (including patient and disease characteristics, treatment patterns and outcomes) were subanalyzed in the context of the patients' residential status [9]. The primary endpoints were OS and PFS.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we have reported the treatment and survival patterns of 2252 patients diagnosed with breast cancer at West China Hospital, Sichuan University between 2005 and 2009 [9]. Here, we present subanalyses of the original dataset to investigate whether inequalities or disparities associated with patients' residential status (rural or urban) exist in the diagnosis, treatment, and long-term outcomes of patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis and treatment pattern among rural and urban breast cancer patients in Southwest China from 2005 to 2009

Peng

Jia²,

Lu³

et al. 2016

Oncotarget

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The incidence of all cancers in China is generally higher in urban areas; however, the mortality risk for affected patients is considerably higher in rural areas. We present a subanalysis investigating the differences in patient and disease characteristics, treatment patterns, and outcomes between rural and urban patients who were diagnosed with breast cancer at West China Hospital between 2005–2009. Baseline patient and disease characteristics were recorded, and patients were followed up for a minimum of 3 years, or until death. For this subanalysis, patients were stratified by their residential status (rural or urban). Of the 2252 patients in the cohort, 76.3% were from urban areas and 22.1% were from rural areas. Significant differences were observed in the prevalence of luminal A and human epidermal growth factor receptor 2-positive breast cancers among rural and urban patients. Estrogen receptor (ER)-positive patients were less likely to receive anti-ER therapy if they were from rural areas compared with urban areas; the use of aromatase inhibitors was also significantly lower for rural patients than urban patients. Univariate, multivariate, and Kaplan–Meier analyses all demonstrated that overall survival and progression-free survival were significantly lower for rural patients than urban patients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosis and treatment pattern among rural and urban breast cancer patients in Southwest China from 2005 to 2009

Peng

Jia²,

Lu³

et al. 2016

Oncotarget

Self Cite

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show abstract

“…With current annual rate of increase, it is projected that by 2021, there would be 2.5 million cases of BC in China. About 20% of BCs in China are TNBC subtype (Peng et al, 2016). TNBC is the most aggressive subtype of BC and is associated with worst prognosis and overall survival (OS; Son et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis

Wang

Zhu

et al. 2019

Journal of Experimental Medicine

150

101

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Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) with the most aggressive phenotype and poor overall survival. Using bioinformatics tools, we identified LINC00908 encoding a 60–aa polypeptide and differentially expressed in TNBC tissues. We named this endogenously expressed polypeptide ASRPS (a small regulatory peptide of STAT3). ASRPS expression was down-regulated in TNBCs and associated with poor overall survival. We showed that LINC00908 was directly regulated by ERα, which was responsible for the differential down-regulation of LINC00908 in TNBCs. ASRPS directly bound to STAT3 through the coiled coil domain (CCD) and down-regulated STAT3 phosphorylation, which led to reduced expression of VEGF. In human endothelial cells, a mouse xenograft breast cancer model, and a mouse spontaneous BC model, ASRPS expression reduced angiogenesis. In a mouse xenograft breast cancer model, down-regulation of ASRPS promoted tumor growth, and ASRPS acted as an antitumor peptide. We presented strong evidence that LINC00908-encoded polypeptide ASRPS represented a TNBC-specific target for treatment.

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Disease progression model of 4T1 metastatic breast cancer

Yang

Ling

Zhu

et al. 2020

J Pharmacokinet Pharmacodyn

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Treatment and survival patterns of Chinese patients diagnosed with breast cancer between 2005 and 2009 in Southwest China

Abstract: Supplemental Digital Content is available in the text

Cited by 22 publications

References 21 publications

Diagnosis and treatment pattern among rural and urban breast cancer patients in Southwest China from 2005 to 2009

Diagnosis and treatment pattern among rural and urban breast cancer patients in Southwest China from 2005 to 2009

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis

Disease progression model of 4T1 metastatic breast cancer

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