Treatment and Prognosis in Seminoma of the Testis

Maier, John G.; Mittemeyer, Bernhard T.; Sulak, Michael H.

doi:10.1016/s0022-5347(17)62645-4

Cited by 61 publications

(8 citation statements)

References 6 publications

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“…For seminoma, radiotherapy without retro peritoneal lymphadenectomy is highly successful [7,8,14,20], Embryonal carcinoma and teratocarcinoma may benefit from retroperitoneal lymph adenectomy [31]. It appears that radiotherapy, either after or in sandwich fashion before and after node dissection, may also improve survival [7].…”

Section: After the Diagnosismentioning

confidence: 99%

“…When no response is seen in the patient with the anaplastic type of seminoma, the likelihood of the metastasis being of another histologic type should be remembered [20], For patients with this variant, serial sections at time of initial diagnosis may reveal additional histologic components [20], Biopsy of the non responsive metastasis may also reveal the additional histologic pattern [10].…”

Section: Chemotherapy Of Seminomamentioning

confidence: 99%

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Chemotherapy of Testicular Germinal Tumors

Priest¹,

Fletcher²

1973

Oncology

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Testicular tumors are the leading cause of death from cancer in men from the age of 25 to 34 years, excluding leukemia and lymphoma. Except for the radiosensitive seminoma, results of treatment for these tumors have been disappointing, and chemotherapy is frequently employed. Combination therapy either simultaneous or sequential, appears to be superior to use of a single agent. Individualization of treatment is important in chemotherapy of disseminated testicular neoplasm, and the many agents that have shown efficacy should be appreciated.

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Section: After the Diagnosismentioning

confidence: 99%

Section: Chemotherapy Of Seminomamentioning

confidence: 99%

Chemotherapy of Testicular Germinal Tumors

Priest¹,

Fletcher²

1973

Oncology

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“…In the first group (6 cases), the initial disease was successfully treated and all patients are free of disease for 14, 13, 13, 3, 3, and 3 years, respectively. T h e latter 3 may still be at risk for late metastasis.…”

Section: Figure 7 Ementioning

confidence: 99%

“…The second group comprises 3 patients whose clinical aggressiveness is manifested by late metastasis or a second primary tumor 7, 6, and 2 years after the initial disease was treated. T h e first 2 cases (8, 9) had widespread remote metastasis (Fig.…”

Section: Figure 7 Ementioning

confidence: 99%

“Seminoma with trophocarcinoma”.A clinical variant of seminoma

Friedman

Pearlman

1970

Cancer

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Seminoma occasionally contains foci of trophocarcinoma (embryonal carcinoma), or else has histologic features of aggressive growth. The resultant variants are classified into: anaplastic seminoma, borderline seminoma, and seminoma with trophocarcinoma. The latter variant is characterized by specific histologic features and, compared with pure seminoma, by more aggressive clinical behavior, larger required tumor lethal radiation dose, and lower survival rate. The intimate association of primordial trophoblastic structures with seminoma is of histogenetic interest.

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“…Seminomas, which account for -40% (27-71%) of testicular cancers, generally tend to present as local (Stage I) or locoregional (Stage II) disease in 70-90% of the patients (Calman et al, 1979;Dixon & Moore, 1952;Maier et al, 1968;Mostofi, 1973;Thomas et al, 1982). Orchiectomy and retroperitoneal radiotherapy in Stage I and minimal Stage II disease usually result in an excellent overall prognosis, with 5-year survival rates approaching 90%.…”

mentioning

confidence: 99%