Treatment and prevention of equine gastric ulcer syndrome

Buchanan, Benjamin R.; Andrews, Frank M.

doi:10.1016/j.cveq.2003.08.012

Cited by 69 publications

(63 citation statements)

References 53 publications

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“…The most common equine gastric disease is gastric ulceration, while gastric impactions and neoplasia are reported infrequently (10,12,30,56,59). Gastric ulceration affects between 53 to 90% of adult horses and has been associated with colic, weight loss, and decreased performance (38,61).…”

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confidence: 99%

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Perkins

Bakker

Burton

et al. 2012

Appl Environ Microbiol

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ABSTRACTLittle is known about the gastric mucosal microbiota in healthy horses, and its role in gastric disease has not been critically examined. The present study used a combination of 16S rRNA bacterial tag-encoded pyrosequencing (bTEFAP) and fluorescencein situhybridization (FISH) to characterize the composition and spatial distribution of selected gastric mucosal microbiota of healthy horses. Biopsy specimens of the squamous, glandular, antral, and any ulcerated mucosa were obtained from 6 healthy horses by gastroscopy and from 3 horses immediately postmortem. Pyrosequencing was performed on biopsy specimens from 6 of the horses and yielded 53,920 reads in total, with 631 to 4,345 reads in each region per horse. The microbiome segregated into two distinct clusters comprised of horses that were stabled, fed hay, and sampled at postmortem (cluster 1) and horses that were pastured on grass, fed hay, and biopsied gastroscopically after a 12-h fast (cluster 2). The types of bacteria obtained from different anatomic regions clustered by horse rather than region. The dominant bacteria in cluster 1 wereFirmicutes(>83% reads/sample), mainlyStreptococcusspp.,Lactobacillusspp. and,Sarcinaspp. Cluster 2 was more diverse, with predominantlyProteobacteria,Bacteroidetes, andFirmicutes, consisting ofActinobacillusspp.Moraxellaspp.,Prevotellaspp., andPorphyromonasspp.Helicobactersp. sequences were not identified in any of 53,920 reads. FISH (n= 9) revealed bacteria throughout the stomach in close apposition to the mucosa, with significantly moreStreptococcusspp. present in the glandular region of the stomach. The equine stomach harbors an abundant and diverse mucosal microbiota that varies by individual.

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confidence: 99%

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Perkins

Bakker

Burton

et al. 2012

Appl Environ Microbiol

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“…The most common clinical sings are weight loss (Murray et al, 1989;Dionne et al, 2003), poor performance and gastrointestinal symptoms (Andrews and Nadeau, 1999;Dionne et al, 2003). EGUS treatment aims to promote ulcers healing, eliminate clinical signs and prevent the onset of recurrences (Buchanan and Andrews, 2003). The therapeutic approach includes management strategies and drugs administration (Hepburn, 2001;Sykes and Jokisalo, 2015).…”

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confidence: 99%

Efficacy of the Administration of a Natural Feed Supplement in the Management of Equine Gastric Ulcer Syndrome in 7 Sport Horses: A Field Trial

Stucchi¹,

Zucca²,

Alessia³

et al. 2017

American Journal of Animal and Veterinary Sciences

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Equine Gastric Ulcer Syndrome (EGUS) is one of the most common causes of poor performance in the equine patient and affects more than 90% of Standardbred and Thoroughbred racehorses in training. Nowadays, the principal therapeutic options for EGUS treatment include antiacids such as histamine receptor antagonists and proton pump inhibitors. Recently, many studies concerning feed supplements to treat and prevent EGUS were carried out. The aim of the present study was to evaluate the efficacy of a natural feed supplement, administered for 30 days, as the only treatment for gastric ulcerations in sport horses in training. Seven horses were selected for the study on the basis of their gastroscopic evidence of erosive and ulcerative lesions of the gastric mucosa. Each horse received a natural feed supplement (Gastrocure, Institute Farmaceutico Candioli, Italy) registered for use in horses for 30 days. Gastroscopy was performed on day 0 (T 1 ), day 15 (T 2 ) and at the end of the treatment (day 30, T 3 ). Scores were assigned according to MacAllister method (score 0,1,2,3,4 for number of lesions and score 0,1,2,3,4,5 for lesion severity). Statistical analysis showed a strong evidence (p<0.01) of lower scores occurring at T 3 when compared to T1for both number and severity of gastric lesions. In conclusion, the administration of Gastrocure was effective in reducing the number and severity of ulcerative lesions in horses affected by EGUS.

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“…These conditions accompany delayed gastric emptying, indicating injury of the gastric mucosa by voluminous residual gastric juice, which then develops into a severe gastric ulcer [1,3]. For this reason, understanding the mechanism of gastric emptying is an important step in the prevention and treatment of upper GI dysfunctions in horses.…”

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Use of 13C-Acetate Breath Test for Assessment of Gastric Emptying in Horses

Sasaki

Aiuchi

Yamada

2005

The Journal of Veterinary Medical Science

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ABSTRACT. This study aimed to establish and standardize a breath test that uses 13 C-acetate in a liquid diet for evaluation of gastric emptying in horses. Seven adult healthy thoroughbreds were used in this study. They were given 13 C-acetate (125 mg, 250 mg, or 500 mg) in a test meal (2000 ml liquid diet) via an intranasal catheter.13 C concentrations in the exhaled CO 2 were measured in samples taken before and after test meal administration using an infrared absorption spectroscope. In the 500 mg 13 C-acetate group, ∆ 13 CO 2 showed a steep gradient immediately after meal administration compared to the 125 mg and 250 mg groups. Therefore, t max in the 500 mg group was easier to determine than in the 125 mg and 250 mg groups. In the 500 mg group, GEC, half-empty time (t1/2), calculated t max (t lag ), and t max were 1.95 ± 0.28 (mean ± SD), 229.2 ± 57.0 (min), 139.2 ± 22.2 (min), and 124.0 ± 28.4, respectively. Differences in CV observed in the 500 mg group were lower than those in the 125 mg and 250 mg groups. This study demonstrates that the 13 C-acetate breath test is useful for evaluating gastric emptying in horses since it is non-invasive and does not require set up of special facilities or equipment. Optimum evaluation of gastric emptying in horses can be achieved with 500 mg of 13 C-acetate given in a liquid diet.KEY WORDS: 13C-acetate breath test, equine, gastric emptying, gastrointestinal dysfunctions.

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Treatment and prevention of equine gastric ulcer syndrome

Cited by 69 publications

References 53 publications

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Equine Stomachs Harbor an Abundant and Diverse Mucosal Microbiota

Efficacy of the Administration of a Natural Feed Supplement in the Management of Equine Gastric Ulcer Syndrome in 7 Sport Horses: A Field Trial

Use of 13C-Acetate Breath Test for Assessment of Gastric Emptying in Horses

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