Treatment and evaluation of specific toxins

Beuhler, Michael C.

doi:10.1002/9781119756279.ch47

Cited by 2 publications

(1 citation statement)

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“…Organophosphate chemicals are widely obtained over the counter, and little thought is paid to their management even though they have been used for suicide, especially in developing countries [ 3 ]. Organophosphate insecticides have dangerous side effects, including respiratory collapse, severe poisoning increased saliva and tear production, confusion, vomiting, sweating, small pupils with acute fasciculation, and immobility [ 4 , 5 ]. Organophosphate poisoning results in three primary syndromes: (i) acute cholinergic syndrome; (ii) intermediate syndrome; and (iii) delayed polyneuropathy [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Poisoning by Organophosphate Pesticides: A Case Report

Bereda¹

2022

Cureus

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In many parts of the world, particularly in impoverished nations like Ethiopia, organophosphate compounds operate as suicide agents, are frequently employed as pesticides, and are strong inhibitors of the acetylcholinesterase enzyme. A 21-year-old Ethiopian female, a university student, was admitted to an emergency department on June 22, 2022, with a two-hour history of nausea and elevated secretions of salivation via the mouth. She had no previous history of psychiatric or neurological disorders, but three days before her admission, she quarreled with her boyfriend, became extremely depressed, and decided to commit suicide. She had a two-hour history of nausea and intermittent vomiting and a one-hour history of persistent vomiting, increased salivation secretions through the mouth, chills, progressive sweating, difficulty breathing, and dizziness. Upon admission, her neurological examination in the emergency department revealed a Glasgow Coma Scale score of 9/15. On admission, she was placed on two liters per minute of intranasal oxygen via the nasal cannula. On the same day, she was given atropine 0.15 mg intravenously, and the dose was doubled every 10 minutes until atropinization was achieved, and a bolus dose of 500ml of 0.9% of normal saline was initiated immediately.

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