Treatment allocation in hepatocellular carcinoma: Assessment of the BCLC algorithm

Richani, Mandy; Kolly, Philippe; Knoepfli, Marina; Herrmann, Evelyn; Zweifel, Martin; Tengg-Kobligk, Hendrik von; Candinas, Daniel; Dufour, Jean–François

doi:10.5604/16652681.1184233

Cited by 43 publications

(37 citation statements)

References 25 publications

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“…AFP is commonly used to diagnose and monitor HCC patients’ conditions after surgery [26], but its role in early dignosis and predicting prognosis of HCC were still in debate, especially some HCC patients were still AFP-negative, so AFP still had some limitations as an screening or predictive indicator. Satellite lesions indicate the cancer is not confined to one site and has disseminated in the liver [27]; encapsulation help limit the tumor in a separate enclosure and prevent it from spreading [28]; BCLC stage 0 + A [29] is common early HCC assessments. These factors were considered to be recurrence related, and the negative condition of them had low indices of clinical suspicion.…”

Section: Discussionmentioning

confidence: 99%

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

et al. 2017

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BackgroundHepatocellular carcinoma has high incidence and mortality worldwide. Liver is the site of most metabolic biotransformation, which could reflect the status of cells. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver. Therefore, the effects of lipid metabolites on prognosis of HCC deserved to be explored.MethodsWe prospectively included 58 healthy donors (HD), 50 chronic hepatitis (CH) patients and a training cohort of 189 patients with HCC who underwent curative resections at Zhongshan Hospital from January 2012 to August 2012. We identified the optimal HDLPO cutoff value at 0.98 mmol/L and used it to stratify patients into low- or high-HDLPO groups for the entire cohort and four low-recurrent-risk subgroups. We also included an independent validation group of 182 HCC patients to validate this cutoff value. Prognostic values of HDLPO and other factors were determined by Kaplan–Meier curves and the Cox proportional hazards model.ResultsThe low-HDLPO group had a higher median tumor grade (P = 0.020) and a higher recurrence rate (P = 0.032). Results of multivariate analysis showed that preoperative γ-glutamyl transpeptidase (GGT) and HDLPO were independent predictors of recurrence. Moreover, the predictive value of HDLPO was retained in four low-recurrent-risk subgroups. As expected, clinicopathologic characteristics and predictive values were similar in the validation and training cohorts.ConclusionsHDLPO is an accessible predictor of HCC recurrence after liver resections that can help identify patients who need more careful monitoring and follow-up care.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0509-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

et al. 2017

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“…Data were taken from 240 patients who had entered the Bern HCC cohort, a prospective cohort, since August 1, 2010 . For inclusion into the Bern cohort, patients had to be >18 years old and were included in the cohort for ≤12 months after first diagnosis.…”

Section: Methodsmentioning

confidence: 99%

“…Data were taken from 240 patients who had entered the Bern HCC cohort, a prospective cohort, since August 1, 2010. 18,19 For inclusion into the Bern cohort, patients had to be >18 years old and were in- Cumulative survival rates were calculated by the Kaplan-Meier method and survival curves were compared by the log-rank test. Cox proportional hazard regressions were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Effect of smoking on survival of patients with hepatocellular carcinoma

Kolly

Knöpfli

Dufour

2017

Liver International

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“…The BCLC staging system takes tumor stage, liver function, and physical status into account, and this system had been widely adopted for HCC staging and treatment (54). Moreover, the BCLC staging system is the only staging system that assigns treatment strategies based on specific prognostic subclasses, an approach that has proven effective (55).…”

Section: Treatment Criteria Based On the Bclc Staging Systemmentioning

confidence: 99%

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines from 2001 to 2017

Song

Cai

Tang

et al. 2017

BST

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Treatment allocation in hepatocellular carcinoma: Assessment of the BCLC algorithm

Cited by 43 publications

References 25 publications

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

A new use for an old index: preoperative high-density lipoprotein predicts recurrence in patients with hepatocellular carcinoma after curative resections

Effect of smoking on survival of patients with hepatocellular carcinoma

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines from 2001 to 2017

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