Treatment Adherence, Quality of Life and Clinical Variables in HIV/AIDS Infection

Reis, Ana Catarina; Guerra, Marina Prista; Lencastre, Leonor

doi:10.4236/wja.2013.33032

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…This fact can be justified by the fact that PI composed more complex regimens, using at least three ARV pills per day, making it difficult to insert daily pills into the patients' routine. In a study performed in Portugal (Reis, Guerra, Lencastre, 2013), it was also shown that complex regimens, with higher number of pills per day, constitute a barrier to adherence. This result was also verified in a study performed in Brazil (Cancian et al, 2015), reporting that regimens composed of NRTI + NNRTI have a simpler dosage profile, a more favorable toxicity profile, facilitating adherence and viral suppression for longer.…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical care and evaluation of adherence to antiretroviral therapy in people living with HIV/AIDS

Schoenherr

Santos

Remor

et al. 2022

Braz. J. Pharm. Sci.

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Highly Active Antiretroviral therapy (HAART) depends on optimal adherence to be effective. Pharmacotherapeutic follow-up can be used as a strategy for treatment fidelity. To provide pharmaceutical care for HAART patients, to assess adherence, to identify and resolve drug related problems (DRP). This is a prospective, interventional study aimed at people on HAART. Data was collected using the pharmacotherapeutic follow-up form and CEAT-VIH. There was a predominance of women (59.1%), older than 33 years (75%), mostly single (43,2%). Regarding adherence, (63.6%) had insufficient adherence at the start of the study, while (36.4%) had strict/ adequate adherence. After the pharmacotherapeutic follow-up, (70,4%) presented strict/adequate adherence. Regarding HAART, the relationship between adherence versus time of HAART and adherence versus regimen used was significant, considering that less time of therapy and regimen containing protease inhibitors are predictors for insufficient adherence. Regarding the DRP identified (f=77), missed pills (32.4%), untreated disease, incorrect management frequency, and undue self-medication (11.7%) were the most frequent. Pharmaceutical interventions (f=137) were predominantly advising related to specific pharmacological treatment (32.1%), nonpharmacological measures (19.7%), and medication suspension (8.7%). Pharmaceutical care was shown to be animportant strategy, within the multi professional team, to improve adherence, besides identifying and resolving DRP.

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Section: Discussionmentioning

confidence: 99%

Pharmaceutical care and evaluation of adherence to antiretroviral therapy in people living with HIV/AIDS

Schoenherr

Santos

Remor

et al. 2022

Braz. J. Pharm. Sci.

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“…The low number of studies and the differing results suggest that further research is needed to determine whether adherence to STRs translates into improved virologic and clinical outcomes. Although a limited number of studies have demonstrated that STRs are associated with lower rates of disease progression and mortality compared with MTRs,9,65,66 it is crucial that future research addresses this gap in our understanding of how pill burden impacts viral suppression so that the needs of patients are better addressed.…”

Section: Discussionmentioning

confidence: 99%

<p>Adherence to HIV treatment regimens: systematic literature review and meta-analysis</p>

Altice¹,

Evuarherhe²,

Shina³

et al. 2019

PPA

158

125

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Background Antiretroviral therapy (ART), when taken consistently, reduces morbidity and mortality associated with human immunodeficiency virus and viral transmission. Suboptimal treatment adherence is associated with regimen complexity and high tablet burden. Single-tablet regimens (STRs) provide a complete treatment regimen in a single tablet. This study examined the relationship between STRs (vs multiple-tablet regimens [MTRs]), treatment adherence, and viral suppression. Methods A systematic review was conducted to identify studies investigating at least one of the following: (1) STR/MTR use and adherence; (2) levels of adherence and viral suppression; and (3) STR/MTR use and viral suppression. Meta-analysis was performed to assess the relationship between STR vs MTR use and adherence in observational settings at ≥95% and ≥90% adherence thresholds. Results In total, 29 studies were identified across the three objectives; two studies were relevant for all objectives. STRs were associated with higher treatment adherence than MTRs in 10/11 observational studies: a 63% greater likelihood of achieving ≥95% adherence (95% CI=1.52–1.74; P <0.001) and a 43% increase in the likelihood of achieving ≥90% adherence (95% CI=1.21–1.69; P <0.001). Higher adherence rates were associated with higher levels of viral suppression in 13/18 studies. Results were mixed in five studies investigating the association between STR or MTR use and viral suppression. Conclusion Although the direct effect of STRs vs MTRs on viral suppression remains unclear, this study provided a quantitative estimate of the relationship between STRs and ART adherence, demonstrating that STRs are associated with significantly higher ART adherence levels at 95% and 90% thresholds. Findings from the systematic review showed that improved adherence results in an increased likelihood of achieving viral suppression in observational settings. Future research should utilize similar measures for adherence and evaluate viral suppression to improve assessment of the relationship between pill burden, adherence, and viral suppression.

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“…Significant efforts have been exerted to scale-up HAART uptake in developing countries; particularly in sub–Saharan Africa, where the epidemic has had its most devastating impact. However, there are concerns about impact of HAART on the QoL of people living with HIV/AIDS (PLWHA), where it is influenced by multiple factors [ 9 – 11 ]. According to the World Health Organization (WHO), QoL is defined as individuals’ perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals, standards, expectations and concerns they have [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

Desta¹,

Biru

Kefale

2020

PLoS ONE

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Background Highly Active Antiretroviral Therapy (HAART) is a standard of HIV management to suppress viral load and delay progression to AIDS. However, questions have been raised about the use of antiretroviral therapy and how it affects quality of life (QoL) of people living with HIV/ AIDS (PLWHA). The study hence aimed to assess the QoL of PLWHA who were taking HAART at Mizan-Tepi University Teaching Hospital (MTUTH) and identify factors associated with QoL. Methods A cross sectional study was conducted among PLWHA receiving HAART at MTUTH from March 04-April 1, 2018. Patients were recruited consecutively and interviewed with structured questionnaire. A data abstraction tool was used to extract data from patient medical records. Quality of life was assessed using the World Health Organization Quality of Life HIV-BREF (WHOQOL-HIV-BREF) standard tool. Data was entered to Epi-Info version 3.5.3 and analyzed using SPSS version 22 for windows. A multivariable logistic regression analysis was fitted to identify factors associated with QoL. A statistical significance was established at a p value <0.05. Results A total of 240 participants with the mean age of 35.11 (SD = 9.08) years were included in the study. This study found that 57.1% of the patients had high global score of QoL. Patients with normal current health (AOR = 3.38, 95% CI = 1.56-7.31)) and having family support (AOR = 3.12, 95% CI = 1.51-6.46) were positively associated with high global score of QoL, while patients with low HAART adherence (AOR = 0.40, 95%, CI = 0.19-0.86) were negatively associated with high global score of QoL.

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Treatment Adherence, Quality of Life and Clinical Variables in HIV/AIDS Infection

Cited by 8 publications

References 16 publications

Pharmaceutical care and evaluation of adherence to antiretroviral therapy in people living with HIV/AIDS

Pharmaceutical care and evaluation of adherence to antiretroviral therapy in people living with HIV/AIDS

<p>Adherence to HIV treatment regimens: systematic literature review and meta-analysis</p>

Health related quality of life of people receiving highly active antiretroviral therapy in Southwest Ethiopia

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