Treatment adherence in chronic myeloid leukemia: a systematic review of the literature

Eliasson, Lina

doi:10.2217/cpr.11.127

Cited by 2 publications

(8 citation statements)

References 57 publications

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“…The 20 participants were aged between 36-75 years (mean 60.9) and had been diagnosed for [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] years (mean 6.23). 18 had a partner, all had children (four living at home) and 13 were grandparents.…”

Section: Resultsmentioning

confidence: 99%

“…With the introduction of the tyrosine kinase inhibitor (TKI) imatinib in 2001, CML patients have obtained revolutionary survival rates close to normal [6].…”

Section: Introductionmentioning

confidence: 99%

“…'the extent of conformity to the recommendations about day to day treatment by the provider with respect to timing, dosage and frequency' [3] is crucial to achieve optimal treatment response [6][7][8]11,12,17,[26][27][28][29][30][31]32]. Yet the fact that CML has become a manageable chronic disease with much improved quality of life (QoL) may challenge adherence [4,8,26].…”

mentioning

confidence: 99%

“…Non-adherence in up to 25-30% of CML patients have been suggested [4,7,19,[26][27][28]30,33]. Side effects are the most frequent reason for intentional non-adherence and has been associated with a negative impact on activities such as travels, other illness, psycho-social well-being and QoL [3,4,6,7,[9][10][11][13][14][15]17,26,29,31,33,34].…”

mentioning

confidence: 99%

“…Non-adherence has also been linked to lacking knowledge about CML and treatment, co-payment, poor communication from health care providers and complacency due to sustained disease control [2][3][4]6,7,[10][11][12]14,17,19,[26][27][28][29][30][31][32][35][36][37][38][39]. Results diverge about adherence and type of TKI and may relate to the drug as well as patients' experiences with earlier treatments [7,8,19].…”

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confidence: 99%

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Drivers and Barriers to Medication Adherence in Patients with Chronic Myeloid Leukaemia: A Qualitative Study

Mortensen¹,

Mourek

2017

JHOR

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With the introduction of tyrosine kinase inhibitors (TKI), patients with chronic myeloid leukemia (CML) have obtained survival rates close to normal. It may appear paradoxical, then, that medication adherence is suboptimal in some health care settings. As the first of its kind, this study aimed to explore drivers and barriers to TKI treatment adherence in Danish CML patients. A literature study informed the design of qualitative interviews with 20 patients, individually and in focus groups, focusing on their disease perceptions of CML, their health-related quality of life (QoL) and medication adherence. The study showed that many participants had previously switched treatment due to lacking efficacy or intolerance but most felt their current disease burden was tolerable. Anxiety might, however, resurface if treatment stopped working or with the occurrence of infections or side effects, creating a state of 'fragile peace'. To these patients, their role functioning -as professionals, spouses, parents and grandparents -was crucial to uphold a positive self-image and meaningful life. Whether treatment enabled or hindered this was thus decisive to their QoL and medication adherence. Our participants expressed high adherence rates with only one having intentionally non-adhered due to side effects and poor QoL. Most participants felt well-informed about CML and treatment and privileged to receive specialised personal care from the public health care system acting to motivate their medication adherence. As a novel finding, this study indicates that the prospect of treatment-free remission may positively affect adherence. We suggest this should be explored in future studies.

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Section: Resultsmentioning

confidence: 99%

“…With the introduction of the tyrosine kinase inhibitor (TKI) imatinib in 2001, CML patients have obtained revolutionary survival rates close to normal [6].…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Drivers and Barriers to Medication Adherence in Patients with Chronic Myeloid Leukaemia: A Qualitative Study

Mortensen¹,

Mourek

2017

JHOR

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Contribution of social and demographic parameters to the long-term survival prognosis of chronic myeloid leukemia patients

Куликов¹,

Лазарева²,

Туркина³

et al. 2021

Gematologiâ i transfuziologiâ

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Introduction. Therapy of chronic myeloid leukemia (CML) for the majority of patients is associated with continuous lifelong drug intake. Irregular drug intake greatly increases the risk of CML progression and death. It is still not well understood to what extent social and demographic factors infl uence the long-term consequences of CML therapy.Aim — to determine the prognostic value of social parameters like marital status and education level in comparison with standard risk factors for the course of the disease.Materials and methods. A multifactorial data analysis of the presented sociodemographic parameters was carried out on a cohort of CML patients included in the multicenter observational study “Russian Registry for the Treatment of Chronic Myeloid Leukemia in Routine Clinical Practice”. The database of the study conducted in Russia in 2011–2016 includes records of 12160 patients with CML. To analyze the register data, we used classical methods of event analysis implemented in the SAS 9.4 package.Results. A large volume of data with a high level of signifi cance showed that educational level and marital status have a great prognostic value in assessing the long-term results of therapy in patients with CML, comparable to known risk factors. The contribution of these signs was evaluated and analyzed taking into account such known factors as age, ELTS index, and region or clinic where the patient was observed and treated. Thus, low educational qualifi cations and marital status “divorced” or “widowed” demonstrated signifi cant and independent risk factors that negatively affect the life expectancy of patients with CML Conclusion. The discovered phenomenon is key in long-term survival and can be explained by the indirect infl uence of social-demographic parameters through adherence behavior of CML patients. Higher level of education proved to be a favorable factor while a widowed/divorced marital status was found to be an unfavorable factor of OS prognosis. General clinic, age related interpretations, and regional features were also tested and did not fi nd any confi rmation.

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Treatment adherence in chronic myeloid leukemia: a systematic review of the literature

Cited by 2 publications

References 57 publications

Drivers and Barriers to Medication Adherence in Patients with Chronic Myeloid Leukaemia: A Qualitative Study

Drivers and Barriers to Medication Adherence in Patients with Chronic Myeloid Leukaemia: A Qualitative Study

Contribution of social and demographic parameters to the long-term survival prognosis of chronic myeloid leukemia patients

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