Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in Xinjiang, China: a prospective study

Gong, Xinji; Li, Yuehua; Wang, Jing; Wu, Gang; Mohemaiti, Ayinuer; Wushouer, Qimanguli; Yao, Lidan; Lv, Jianghua; Li, Rongrong; Li, Pengfei; Wang, Buqing

doi:10.1039/c7ra11820a

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…the knowledge, attitude, and practice level of newly treated smear-positive pulmonary tuberculosis patients. Therefore, in the management of newly treated smearpositive pulmonary tuberculosis patients, attention should be paid to communicating with and effectively guiding patients and their families, as well as improving patient compliance to improve the knowledge, attitude, and practice level of newly treated smear-positive pulmonary tuberculosis patients and promote overall rehabilitation [15,16].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a case management model in newly treated smear-positive pulmonary tuberculosis patients

Wang

et al. 2021

J Infect Dev Ctries

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Introduction: To investigate the effectiveness of the case management mode on the application of smear-positive pulmonary tuberculosis patients. Methodology: This was a randomized control trial. A total of 70 newly diagnosed smear-positive pulmonary tuberculosis patients were recruited and been randomly divided into experimental group and control group, with 35 participants in each group. In the experimental group, patients received the tuberculosis case management mode based on the conventional management mode. In the control group, patients received the routine management mode. We compared the knowledge, attitude, and practice score; sputum-negative conversion rate, effective imaging rate of the two groups at the time of initial admission, discharge, and one month after discharge. Results: The results showed that there was no significant difference in baseline data between the two groups (p > 0.05); at the time of discharge and one month after discharge, the knowledge, belief, behavior, sputum-negative conversion rate, and imaging examination effective rate of the experimental group were higher than those of the control group (p < 0.05). Conclusions: The case management mode can improve the knowledge, attitude, and practice level; sputum-negative conversion rate; and imaging efficiency of newly treated smear-positive pulmonary tuberculosis patients.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of a case management model in newly treated smear-positive pulmonary tuberculosis patients

Wang

et al. 2021

J Infect Dev Ctries

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“…In our study, the rate of taking drug was just 48.8% in the villages after internet off at week 6, which may re ect the real treatment compliance rate of village patients by using DOTS as the book marks being always 100% could not re ect the real compliance for taking anti-TB medicine. We believe the low of compliance for taking drugs is the key for the high prevalence of TB in rural area of XUAR, comparing those in Jiangsu (89%), Anhui (90.5%), and Ningxia (93.3%) of China [21] . The developed eDOTS system for promoting compliance may meet the need of control TB in high endemic areas in Xinjiang as the traditional DOTS was not successful in the region.…”

Section: The System Of Edots Is An Effective Tool For Increasing Tb Tmentioning

confidence: 91%

“…Although the international TB control strategy-DOTS was introduced to improve the cure of TB TB control programmes are not fully functioned as required by the guidelines in the remote and impoverished areas of China [19] . Some surveys conducted in recent years have shown that treatment compliance among TB patients is not ideal in China with DOTS management [19][20][21] . In our study, the rate of taking drug was just 48.8% in the villages after internet off at week 6, which may re ect the real treatment compliance rate of village patients by using DOTS as the book marks being always 100% could not re ect the real compliance for taking anti-TB medicine.…”

Section: The System Of Edots Is An Effective Tool For Increasing Tb Tmentioning

confidence: 99%

Improving the control ability of pulmonary tuberculosis with an internet based eDOTS system in the communities of Kashgar and Urumqi, Xinjiang of China

Guo¹,

Sun²,

Wushouer³

et al. 2020

Preprint

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Background: Although the direct observed treatment strategy (DOTS) has been used for the control of pulmonary tuberculosis (PTB) in Xinjiang Uygur Autonomous Region for more than 30 years, the disease is still highly endemic in the region. To increase ability of PTB treatment and control efficacy, we developed a new eDOTS system for reminding, monitoring and educating PTB patients for regularly taking antibiotics.Methods: A total 167 new cases with active PTB from Kashgar villages and Urumqi City in Xinjiang were involved in the study. Among them, 81 patients were from villages with 43 patients using eDOTS system and 38 patients with traditional DOTS as control. Eighty six patients were from township with 50 patients using eDOTS and 36 patients using DOTS. Findings: PTB patients from villages in Kashgar treated with DOTS showed low compliance of taking antibiotics, only 27.9% the patients took medicine consistently once the network service for eDOTS system was removed. However, with the help of village and hospital doctors through the eDOTS system, the medical compliance were increased to 70-85%. The treatment compliance with eDOTS of patients from township (100%) was significantly higher than that of those patients from the rural villages (49%) in the first 6 weeks ( Χ 2 =33.3, P <0.01). DR X-ray Scores of PTB lesions showed that the patients using eDOTS either from the villages or from township significantly decreased their lesion score points compared to these scores from those patients using DOTS by 1.81 points，95% CI (0.72-2.90) and 1.05 points，95% CI (0.15-1.95) after 25 weeks of treatment, respectively. In the township, those 50 patients were looked after by one community doctor with eDOTS. Conclusion: eDOTS is an effective means of treating PTB patients in terms of reducing doctor’s work and increasing the compliance of taking antibiotics regularly during the treatment course. One doctor can easily look after 50 or more PTB patients through the eDOTS system. The constantly education program online through the system for the patients especially in villages plays an important role in encouraging TB patients taking antibiotics for a long period.

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“…27 The overall pooled estimated prevalence for the Asia region was 17% (95% CI 16% to 18%). The highest pooled prevalence was noted in Southern Asia (22% (95% CI 16% to 29%)), [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] followed by Eastern Asia (18% (95% CI 16% to 20%)), [43][44][45][46][47][48][49][50][51][52][53][54][55] South East Asia (16% (95% 4% to 28%)), [56][57][58][59][60][61] Western Asia (10% (95% 5% to 15%)) [62][63][64] and Central Asia (6% (95% CI 5% to 7%)). 65 66 (figure 2) Subgroup analysis based on the duration of treatment interruption (36 studies, excluded non-defined duration of treatment interruption), demonstrated the pooled prevalence for ≥2 months interruption was 10% (95% CI 9% to 11%), which was much lower than another subgroup that considered the minimum duration of <2 months, 28% (95% CI 20% to 36%) (online supplemental figure S1).…”

Section: Prevalence Of Tb Treatment Interruptionmentioning

confidence: 99%

Prevalence and predictive factors of tuberculosis treatment interruption in the Asia region: a systematic review and meta-analysis

Makmor-Bakry

Islahudin

et al. 2023

BMJ Glob Health

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IntroductionTuberculosis (TB) treatment interruption remains a critical challenge leading to poor treatment outcomes. Two-thirds of global new TB cases are mostly contributed by Asian countries, prompting systematic analysis of predictors for treatment interruption due to the variable findings.MethodsArticles published from 2012 to 2021 were searched through seven databases. Studies that established the relationship for risk factors of TB treatment interruption among adult Asian were included. Relevant articles were screened, extracted and appraised using Joanna Briggs Institute’s checklists for cohort, case–control and cross-sectional study designs by three reviewers. Meta-analysis was performed using the random effect model in Review Manager software. The pooled prevalence and predictors of treatment interruption were expressed in ORs with 95% CIs; heterogeneity was assessed using the I2statistic. The publication bias was visually inspected using the funnel plot.ResultsFifty eligible studies (658 304 participants) from 17 Asian countries were included. The overall pooled prevalence of treatment interruption was 17% (95% CI 16% to 18%), the highest in Southern Asia (22% (95% CI 16% to 29%)), followed by Eastern Asia (18% (95% CI 16% to 20%)) and South East Asia (16% (95% CI 4% to 28%)). Seven predictors were identified to increase the risk of treatment interruption, namely, male gender (OR 1.38 (95% CI 1.26 to 1.51)), employment (OR 1.43 (95% CI 1.11 to 1.84)), alcohol intake (OR 2.24 (95% CI 1.58 to 3.18)), smoking (OR 2.74 (95% CI 1.98 to 3.78)), HIV-positive (OR 1.50 (95% CI 1.15 to 1.96)), adverse drug reactions (OR 2.01 (95% CI 1.20 to 3.34)) and previously treated cases (OR 1.77 (95% CI 1.39 to 2.26)). All predictors demonstrated substantial heterogeneity except employment and HIV status with no publication bias.ConclusionThe identification of predictors for TB treatment interruption enables strategised planning and collective intervention to be targeted at the high-risk groups to strengthen TB care and control in the Asia region.

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Treatment adherence among sputum smear-positive pulmonary tuberculosis patients in Xinjiang, China: a prospective study

Abstract: Background: Despite great effort to control tuberculosis (TB), low treatment adherence threatens the success of drug therapy, increases the risk of TB transmission, and leads to the development of drug resistance.

Cited by 7 publications

References 18 publications

Effectiveness of a case management model in newly treated smear-positive pulmonary tuberculosis patients

Effectiveness of a case management model in newly treated smear-positive pulmonary tuberculosis patients

Improving the control ability of pulmonary tuberculosis with an internet based eDOTS system in the communities of Kashgar and Urumqi, Xinjiang of China

Prevalence and predictive factors of tuberculosis treatment interruption in the Asia region: a systematic review and meta-analysis

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