Treating Traumatic Brain Injury with Minocycline

Bergold, Peter J.; Furhang, Rachel; Lawless, Siobhán

doi:10.1007/s13311-023-01426-9

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…Minocycline is more commonly known for its anti-microbial properties, but this FDA-approved antibiotic has been used to treat symptoms of brain trauma. When it is given in high doses, minocycline has anti-inflammatory, anti-apoptotic, and anti-oxidant properties [40]. It is also able to reduce ferritin [41].…”

Section: Treatment Type Benefits Complications Referencesmentioning

confidence: 99%

“…Clinical trials with minocycline as a treatment for traumatic brain injury have had mixed results. Many of them have failed to replicate the results from the pre-clinical trials, and that could be due to the inability to treat patients within a critical window after injury [40]. Although there are no clinical trials using minocycline to treat hydrocephalus directly, traumatic brain injury can lead to hydrocephalus.…”

Section: Treatment Type Benefits Complications Referencesmentioning

confidence: 99%

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Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options

Newland,

Blazer-Yost

2024

Preprint

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Hydrocephalus is caused by an overproduction of cerebrospinal fluid (CSF), a blockage of fluid circulation, or improper reabsorption. CSF accumulation in the brain’s ventricles causes ventriculomegaly and brain cell damage. Hydrocephalus can be caused by brain trauma, hemorrhage, infection, tumors, or genetic mutations. Currently, there is no cure for hydrocephalus. Treatments like shunting and endoscopic third ventriculostomies are used, but unfortunately, these techniques require brain surgery and have high failure rates. To advance the development of hydrocephalus treatments, physiologically relevant pre-clinical models are crucial. This review covers some of the current animal and cell culture methods used to study hydrocephalus. The choroid plexus epithelium (CPe) is thought to be the major producer of CSF in the brain. It is a polarized epithelium that regulates ion and water movement from a fenestrated capillary exudate to the ventricles. Despite decades of research, control of electrolyte movement in the CPe is still not fully understood. This review discusses important transporters on the CPe and how some of these could be potential targets for hydrocephalus treatment.

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Section: Treatment Type Benefits Complications Referencesmentioning

confidence: 99%

Section: Treatment Type Benefits Complications Referencesmentioning

confidence: 99%

Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options

Newland,

Blazer-Yost

2024

Preprint

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Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

Ritter,

Somnuke,

et al. 2024

BMC Neurosci

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TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves patient mortality and outcome is an ongoing matter of debate. In contrast, results from animal models of TBI suggest translational perspectives and support the hypothesis that antibiotics, independent of their anti-microbial activity, alleviate secondary injury and improve neurological outcomes. These beneficial effects were largely attributed to the inhibition of neuroinflammation and neuronal cell death. In this review, we briefly outline current treatment options, including antibiotic therapy, for patients with TBI. We then summarize the therapeutic effects of the most commonly tested antibiotics in TBI animal models, highlight studies identifying molecular targets of antibiotics, and discuss similarities and differences in their mechanistic modes of action.

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Treating Traumatic Brain Injury with Minocycline

Cited by 2 publications

References 71 publications

Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options

Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options

Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

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