Treating post‐dengue mania: Is role of valproate and quetiapine related to histone deacetylase inhibition?

Dinakaran, Damodharan; Tholasappa, Varshitha; Lhamu, Tshering; Sreeraj, Vanteemar S.; Venkatasubramanian, Ganesan

doi:10.1111/bdi.12948

Cited by 2 publications

(6 citation statements)

References 4 publications

(10 reference statements)

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“…At 6-24 months' follow-up after dengue infection, the rates of depression were 15%. 20 There are multiple case reports of manic presentation, [24][25][26][27][28][29][30][31] acute polymorphic psychosis, [32][33][34][35][36][37][38][39] prolonged depression, 40 and catatonia 29,41 and one on rapid cognitive decline. 42 However, the evidence for a psychotic, manic, or catatonic presentation from observational studies is lacking.…”

Section: Psychiatric Manifestationsmentioning

confidence: 99%

“…Mania in dengue patients was managed with antipsychotic/benzodiazepines or a combination of mood stabilizers and antipsychotic/benzodiazepines. 24,[26][27][28][29] For psychotic presentations, a good response was achieved with oral antipsychotic agents, mostly in low doses. [32][33][34][35][36][37]39 Catatonic presentation responded well to intravenous lorazepam 4 mg/day, which was tapered and stopped over four weeks.…”

Section: Management Optionsmentioning

confidence: 99%

Section: Psychiatric Manifestationsmentioning

confidence: 99%

“…22 Only a few studies used standard diagnostic criteria and structured psychopathology and cognition rating scales to quantify the presentation. 17,18,25,26,29 Most studies had little/no information on follow-up details, and retrospective studies had suggested predominant anxiety and depressive symptoms as chronic consequences. However, the persistence of these symptoms and the need for prolonged treatment for secondary psychiatric manifestations are not specifically described in the available studies.…”

Section: Psychiatric Manifestationsmentioning

confidence: 99%

“…Seven of the reviewed reports utilized any one agent (valproate, quetiapine, or carbamazepine) with HDAC/DNMT inhibition. [24][25][26][27][28][29]31,34 These reports suggested an early and favorable outcome. However, reports utilizing other agents without HDAC/DNMT inhibition also suggested favorable outcomes.…”

Section: Review Articlementioning

confidence: 99%

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Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

Dinakaran

Sreeraj

Venkatasubramanian

2021

Indian Journal of Psychological Medicine

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Dengue is an arboviral infection endemic in tropical countries. Neurological sequelae to dengue infection are not uncommon, and psychiatric manifestations are increasingly reported. This narrative review aims to present the varied manifestations, postulated mechanisms, and the available treatment options for psychiatric morbidity associated with dengue. The evidence available from eight observational studies is summarized in this review. Depression and anxiety are noted to be prevalent during both the acute and convalescent stages of the infection. The presence of encephalopathy and other neurological conditions is not a prerequisite for developing psychiatric disorders. However, treatment options to manage such psychiatric manifestations were not specified in the observational studies. Anecdotal evidence from case reports is outlined. Special attention is paid to the role of epigenetic modifications following dengue infections and the role of histone deacetylase inhibitors in the management. DNA methylation inhibitors such as valproic acid play a significant role in reversing stress-, viral-, or drug-induced epigenetic modifications.

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Section: Psychiatric Manifestationsmentioning

confidence: 99%

Section: Management Optionsmentioning

confidence: 99%

Section: Psychiatric Manifestationsmentioning

confidence: 99%

Section: Psychiatric Manifestationsmentioning

confidence: 99%

Section: Review Articlementioning

confidence: 99%

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Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

Dinakaran

Sreeraj

Venkatasubramanian

2021

Indian Journal of Psychological Medicine

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Acute Psychosis and Mania: An Uncommon Complication of Dengue Fever

Elavia,

Patra,

Kumar

et al. 2023

Cureus

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Dengue fever is primarily known as a mosquito-borne viral infection that causes a range of physical symptoms, ranging from myalgia to bleeding tendencies. However, there is growing recognition of its potential to trigger psychiatric manifestations, although such cases remain relatively rare. We report a case of acute dengue fever in a 25-year-old male who developed mania and psychotic symptoms after one week of infection. A comprehensive diagnostic workup, including laboratory tests, including cerebrospinal fluid analysis, and neuroimaging, confirmed the absence of organic causes for his psychiatric symptoms, except for his prior exposure to the dengue virus. The patient was initiated on mood stabilizers and antipsychotic medications, leading to a gradual improvement in his mental health.

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Treating post‐dengue mania: Is role of valproate and quetiapine related to histone deacetylase inhibition?

Cited by 2 publications

References 4 publications

Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

Acute Psychosis and Mania: An Uncommon Complication of Dengue Fever

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