Treating Oral Histoplasmosis in an Immunocompetent Patient

Muñante-Cárdenas, José Luis; Assis, André Moreira de; Olate, Sérgio; Lyrio, Mariana Camilo Negreiros; Moraes, Márcio de

doi:10.14219/jada.archive.2009.0072

Cited by 11 publications

(6 citation statements)

References 23 publications

(20 reference statements)

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“…There are no guidelines or recommendations specific to the treatment of primary cutaneous histoplasmosis owing to the rarity of this condition. However, the resolution of our patient's symptoms with oral itraconazole is consistent with the previously reported cases of primary mucocutaneous histoplasmosis in immunocompetent patients responding to this therapy [1][2][3][4][5][13][14][15]. Despite the known risk of hepatic toxicity with itraconazole and the history of liver cirrhosis in our patient, itraconazole therapy with appropriate laboratory monitoring, including itraconazole levels and liver function tests, was the most appropriate treatment regimen in our patient.…”

Section: Discussionsupporting

confidence: 89%

“…In addition to histoplasmosis, other maladies including malignant neoplasms such as squamous cell carcinoma, persistent trauma, ulcerative lichen planus, and autoimmune blistering disorders are in the differential diagnosis [1,5]. When the diagnosis of primary mucocutaneous histoplasmosis is made, treatment with oral itraconazole is appropriate and has led to resolution of cases described in the literature and presented here [1][2][3][4][14][15].…”

Section: Discussionmentioning

confidence: 99%

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Primary mucocutaneous histoplasmosis in an immunocompetent patient

Kash

Jahan‐Tigh

Efron-Everett

et al. 2015

Dermatology Online Journal

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We report a case of primary mucocutaneous histoplasmosis in an immunocompetent individual. The patient, a 61-year-old woman, presented with a non-healing ulcer on the lateral border of her tongue. Excisional biopsy of the lesion was consistent with histoplasmosis and no evidence of pulmonary or disseminated infection was found. Although mucocutaneous infection has been well-described as a manifestation of disseminated disease, especially in immunocompromised individuals, oral infections in immunocompetent patients are rare.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Primary mucocutaneous histoplasmosis in an immunocompetent patient

Kash

Jahan‐Tigh

Efron-Everett

et al. 2015

Dermatology Online Journal

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“…In immunocompromised patients such as those with HIV presenting with limited or disseminated disease, intravenous liposomal amphotericin B is the treatment of choice as the regular (amphotericin B deoxycholate) form is less used due to adverse reactions [ 48 ]. However, in immunocompetent patients and those with localized disease, itraconazole is the preferred treatment modality as it is safe and has low toxicity compared to amphotericin [ 49 , 50 ]. The prognosis in immunocompetent patients having mild to moderate infections is usually good.…”

Section: Discussionmentioning

confidence: 99%

Oral Localized Lesion on the Tongue in an Immunocompetent Individual: A Report of a Rare Case With a Comprehensive Review of the Literature

Kumar¹,

Gupta²,

Garg³

et al. 2023

Cureus

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Histoplasmosis (HP) is a sporadic deep fungal disease that rarely shows oral lesions in various clinical forms. It is usually associated with immunocompromised states, but oral HP has also been reported in many immunocompetent individuals. An unusual case of focal oral HP in a 65-year-old immunocompetent male is reported from New Delhi, India (non-endemic region) presenting with oral ulcerative lesions on the floor of the mouth and lateral surface of the tongue. This case report highlights the importance of prompt diagnosis for the success of the treatment of oral HP along with a thorough review of the literature on HP in immunocompetent patients with oral manifestations. The average age of immunocompetent patients with oral HP is 49.65 years with a marked male predilection. The most common intraoral site is the tongue, followed by the gingiva. Also, five intraosseous cases of HP in immunocompetent patients are reported, among which four are seen in patients from Africa and in a much younger age group (mean: 17.25 years).

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“…Moreover, immunocompetent individuals may have endogenous reactivation of the disease which may present at a later stage of life, as observed in tuberculosis [8]. Oral involvement in the form of chronic non-healing ulcer or mass lesion of the buccal mucosa, tongue, and palate are seen in 25%–40% of patients with PDH [9]. Oral manifestation of histoplasmosis, though usually associated with chronic disseminated form of the disease, constitutes a rare entity in immunocompetent individuals.…”

Section: Discussionmentioning

confidence: 99%

Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series

Samaddar

Sharma

Kumar

et al. 2019

Medical Mycology Case Reports

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Histoplasmosis is a systemic fungal disease caused by dimorphic fungus Histoplasma capsulatum and is more common in immunocompromised patients. We report two cases of disseminated histoplasmosis in immunocompetent individuals from a non-endemic zone in Western India. Rapid diagnostic tests like urinary antigen detection and molecular assays comprise the need of the hour as early initiation of antifungal therapy can be life-saving. Clinicians need to be aware of this entity to prevent misdiagnosis and initiate prompt effective management.

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Treating Oral Histoplasmosis in an Immunocompetent Patient

Cited by 11 publications

References 23 publications

Primary mucocutaneous histoplasmosis in an immunocompetent patient

Primary mucocutaneous histoplasmosis in an immunocompetent patient

Oral Localized Lesion on the Tongue in an Immunocompetent Individual: A Report of a Rare Case With a Comprehensive Review of the Literature

Disseminated histoplasmosis in immunocompetent patients from an arid zone in Western India: A case series

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