Treating oligohydramnios with extract of Salvia miltiorrhiza: A randomized control trial

Abstract

Objective: To determine whether purifi ed herbal extract of Salvia miltiorrhiza can improve the amniotic fl uid volume in pre-term oligohydramnios by improving uteroplacental circulation. Methods: Forty-three pregnant women with oligohydramnios received a daily intravenous dose of 30 mL of salvia extract mixed with 5% glucose 500 mL. A control group of 41 women received daily 5% glucose 500 mL only. The amniotic fl uid index (AFI) was assessed at least twice a week by ultrasonographists who were blinded to the treatment. Both women and fetuses were monitored closely. The change in AFI was calculated and compared by paired t test within and between groups. The revised recommendations for improving the quality of reports of parallel group randomized trials were used. Results: After a mean of 7.2 ± 2.7 days' therapy, ranging from 3 to 18 days, the AFI increased signifi cantly from a mean of 4.9 ± 2.3 cm to a mean of 7.12 ± 2.36 cm, by a mean of AFI 0.18 ± 0.06 cm/day (paired t = 3.62, p Ͻ 0.005). In the control group, the AFI increased from a mean of 5.1 ± 2.4 cm to a mean of 5.5 ± 3.1 cm after a mean of 6.1 ± 3.3 days' treatment, ranging from 4 to 15 days. The effect of salvia treatment on AFI in the salvia group was signifi cantly greater than in the control group (p Ͻ 0.001). No side effects were observed in treated patients. Conclusion: Salvia miltiorrhiza is an effective Chinese medicine for the treatment of oligohydramnios.

Danshen extract regulates the expression of aquaporin 3 in human amniotic epithelial cells

“…As a traditional Chinese medicine, it has been to treat oligohydramnios for decades. Chu et al (9) identified that Danshen extract was an effective medicine to increase the amniotic fluid volume in pre-term patients suffering oligohydramnios, and the absolute (increased fluid) effective rate of Danshen extract was approximately 70%. But the molecular pathway responsible for the beneficial effects of Danshen extract on oligohydramnios has not been elucidated.…”

“…Wenwen Zhang 1 , Yiwen Zhang 1 , Xiaoli Hu 1 , Huihui Cheng 1 , Ying Hua 1 , Xueqiong Zhu 1 (9). Although efficacy of Danshen extract therapy for oligohydramnios has been proven in clinical research, only effective for some patients and the molecular mechanisms responsible for the beneficial effects of Danshen extract on oligohydramnios remain poorly understood.…”

The therapeutic effect of goreisan to oligohydramnios — Gorei-San increase the single deepest pocket in oligohydramnios —

“…The therapeutic effects on oligohydramnios were speculated to include improvement in the placentalblood circulation and control of membrane permeability at the placenta. 14) So it was speculated that some types of herbal medicines have been effective for the treatment of oligohydramnios.…”

“…Purified herbal extract of Salvia miltiorrhiza also useful to treat oligohydramnios but daily infusion of 500 ml, 14) the ambulatory-treatment isn't easy to manage, although is low degree, have same risk as maternal hydration therapy. 13) On the other hand the risk of Gorei-San treatment is low.…”

Linking expression of aquaporin 3 to activation of JNK pathway

“…Multiple pharmacological activities of S. miltiorrhiza have been identified, including antioxidant and anti-inflammatory activities, and the extract is used to treat miscarriage, edema, and platelet aggregation (15)(16)(17)(18). In recent years, clinical research has confirmed that S. miltiorrhiza effectively improves AFV in oligohydramnios, with approximately 70% cases were found AFV increased (19). In a previous study, we demonstrated that S. miltiorrhiza extract increased AQP3 protein levels in human primary culture amnion epithelium cells (hAECs) obtained from normal AFV and from patients with isolated oligohydramnios (20).…”