Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children

Nonalcoholic Fatty Liver Disease in Children: Unique Considerations and Challenges

“…109 The data regarding the effect of treatment of OSA with continuous positive airway pressure therapy on NAFLD is divergent; although randomized controlled trials of continuous positive airway pressure did not suggest improvement in NAFLD, observational studies of longer duration did show a beneficial effect. 110,111 Larger, long-term prospective trials are desirable, particularly in pediatrics.…”

Non-alcoholic fatty liver disease and childhood obesity

“…Treating children with OSA has been shown to improve NAFLD severity and optimisation of Vitamin D levels may minimise fibrosis [58,59]. Given the frequent association with psychological morbidity, the provision of psychological support as part of multi-disciplinary management may contribute to improved clinical outcomes [60].…”

Perspectives on youth‐onset nonalcoholic fatty liver disease

“…77 Although obesity duration and severity are also associated with a decreased renal function, 78 NAFLD has been shown to be an independent predictor even after further adjustment for other metabolic risk factors and genetic polymorphisms like I148M (rs738409) of PNPLA3. 57,79 Other comorbidities that NAFLD have been associated with include obstructive sleep apnoea (OSA), 80,81 lower whole bone mineral density 82 and polycystic ovary syndrome. 83 In addition, youth-onset NAFLD has been associated with a variety of psychosocial issues as low self-esteem, psychological distress and poor quality of life.…”