Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom‐go: A prospective observational study

Abstract

ObjectivesThe aim of the current study was to investigate the effectiveness and clinical feasibility of Biyeom‐go for the treatment of nasal symptoms associated with rhinitis.DesignProspective observational study.SettingThis study was conducted at the Woosuk Korean Medicine Medical Center in South Korea.ParticipantsFifty‐eight patients with rhinitis participated in this study. All patients received Biyeom‐go treatment >3 times daily for a total of 4 weeks.Main outcome measuresThe primary outcome was the total nasal symptom score. Mini‐rhinoconjunctivitis quality of life questionnaire, nasal endoscopy index, total serum immunoglobulin E levels and immunologic factors in nasal lavage fluid were also measured.ResultsBiyeom‐go administration was associated with significant improvements in total nasal symptoms scores (P < .0001) and mini‐rhinoconjunctivitis quality of life questionnaire scores (P < .0001) in a time‐dependent manner. The nasal endoscopy index also significantly improved at weeks 2 (P = .0049), 3 (P < .0001) and 4 (P = .0001) after Biyeom‐go treatment. Significantly, increased interleukin‐2 levels (P = .005) and decreased interleukin‐8, chemokine (C‐C motif) ligand (CCL) 5, chemokine (C‐X‐C motif) ligand (CXCL) 9, CCL2 and CXCL10 levels were observed in the nasal lavage fluid.ConclusionsThe present findings suggest that Biyeom‐go may be beneficial for the management of rhinitis symptoms and rhinitis‐associated quality of life. Further well‐designed randomised controlled trials are needed to evaluate the effectiveness of Biyeom‐go for rhinitis.

Particulate Matter Exposure and the Changes in Immune Biomarkers: Effects of Biyeom-Go on the Nasal Mucosa of Patients with Allergic Rhinitis and a Particulate Matter-Treated Mouse Model

“…The mucosal immune system in humans is poorly studied; however, it has proven to be important in establishing an effective immune response to airborne pathogens and toxic pollutants such as PM, by stimulating Th1/Th2 cells, cytotoxic T lymphocyte production, plasma, and B cells [ 14 ]. It has been found that BYG treatment is beneficial in the management of rhinitis symptoms and rhinitis-associated quality of life by modulating the immune response [ 9 ]. Here, we examined the effects of BYG on immune biomarkers in patients with rhinitis and mice exposed to PM.…”

“…This prospective observational clinical study was performed at the Woosuk Korean Medicine Medical Center Jeonju-si, Korea, between October 2019 and March 2020. BYG was manufactured by the Dispensary Pharmacy of Woosuk Korean Medicine Medical Center, and the quality was controlled [ 9 ]. Patients were provided with BYG that was used via a cotton swab thrice a day for 4 weeks.…”

“…Biyeom-go (BYG), a herbal ointment, is composed of the Korean Medicine herbal prescription, Hwanglyeonhaedok-tang with Sophorae Radix and Glycyrrhizae Radix et Rhizoma added. It is clinically used in Korea to improve nasal symptoms associated with rhinitis [ 9 ]. Prospective observational studies have shown that Biyeom-go (BYG) helps manage rhinitis symptoms and improves rhinitis-associated quality of life [ 6 , 9 ].…”

“…It is clinically used in Korea to improve nasal symptoms associated with rhinitis [ 9 ]. Prospective observational studies have shown that Biyeom-go (BYG) helps manage rhinitis symptoms and improves rhinitis-associated quality of life [ 6 , 9 ]. IL-2 levels are found to increase, and IL-8, chemokine (C-C motif) ligand (CCL) 5, chemokine (C-X-C motif) ligand (CXCL) 9, CCL2, and CXCL10 levels decrease in the nasal lavage fluid after treatment with BYG.…”

Efficacy and safety of anti-obesity herbal medicine focused on pattern identification: A systematic review and meta-analysis

“…[53] Another study reported the effectiveness of Biyeom-go , which is a herbal ointment for rhinitis, is associated with cold-heat pattern and that ointment can be more effective for patients with heat type compared to cold type. [54] Cheonwangbosim-dan , that has been prescribed for insomnia patients, was studied and it improved sleep quality in insomnia patients with a heart- yin deficiency type compared to non-heat- yin deficiency type. [55] It is hard to conclude that herbal medicine using PI is more effective for obesity, above studies can support the possibility of PI for further improvement on treatment of obesity.…”