Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery

Biolo, Gianni; Cicco, Marcello De; Lorenzon, Stefania; Mas, Viviana Dal; Fantin, D.; Paroni, Rita; Barazzoni, Rocco; Zanetti, Michela; Iapichino, G.; Guarnieri, Gianfranco

doi:10.1097/ccm.0b013e318174de32

Cited by 53 publications

(42 citation statements)

References 36 publications

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“…Consistent with an anabolic role for insulin in humans, a post mortem study of critically ill patients has shown an increase in skeletal muscle protein concentration in those who were treated with intensive insulin therapy compared with controls [119]. Similar results have been shown in burns patients [135] and cancer cachexia [140]. Also, in a recent human study of patients with ICUAW where all participants were treated with intensive insulin therapy, IGF-1 and skeletal muscle protein synthesis were increased and protein breakdown pathways decreased compared with controls.…”

Section: Bioenergenetic Failure Oxidative Stress and Glycaemic Controlsupporting

confidence: 70%

Molecular mechanisms of intensive care unit-acquired weakness

Bloch¹,

Polkey²,

Griffiths³

et al. 2011

Eur Respir J

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Intensive care unit-acquired weakness (ICUAW) is an increasingly recognised and important clinical consequence of critical illness. It is associated with significant morbidity and mortality. The aetiology of this disease is not well understood. The purpose of this article is to review our understanding of the molecular pathogenesis of ICUAW in the context of current knowledge of clinical risk factors and aetiology.Key features of the disease are loss of muscle mass resulting from a shift in the dynamic balance of muscle protein synthesis and breakdown and a reduction in force-generating capacity. These alternations are secondary to neuropathy, disruption of the myofilament structure and function, a disrupted sarcoplasmic reticulum, electrical inexcitability and bioenergenetic failure.As knowledge and understanding of ICUAW grows, potential therapeutic targets will be identified, hopefully leading to multiple strategies for prevention and treatment of this important condition.

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Section: Bioenergenetic Failure Oxidative Stress and Glycaemic Controlsupporting

confidence: 70%

Molecular mechanisms of intensive care unit-acquired weakness

Bloch¹,

Polkey²,

Griffiths³

et al. 2011

Eur Respir J

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“…160 After major surgery for cancer, hyperglycemia induced by parenteral nutrition was associated with muscle protein catabolism, while maintenance of normoglycemia restored a neutral protein balance. 161 Similar observations were made more recently in patients receiving intensive care, particularly during the early stages of critical illness. 162 …”

Section: Assessment Of Catabolism Before Surgerysupporting

confidence: 69%

Perioperative catabolism

Schricker

Lattermann

2015

Can J Anesth/J Can Anesth

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“…The adequate treatment of hyperglycaemia favours muscle amino-acid and protein metabolism [98,99]. The data in the literature on PN testify to the initial infusion of a quantity of glucose that avoids overfeeding.…”

Section: Parenteral Nutrition and Insulin Treatmentmentioning

confidence: 99%