Treating facial soft tissue deficiency: Fat grafting and adipose-derived stem cell tissue engineering

Sajjadian, Ali; Magge, Keshav T.

doi:10.1016/j.asj.2006.12.001

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…By combining stem cell technology with other bioengineering tools, such as biodegradable three-dimensional matrices/scaffolds, tissue-specific growth factors, and gene therapy, the realization of an ideal modality for reconstructive surgery is well within our grasp [20,21]. In vivo grafts demonstrated the formation of substantial adipose tissue encapsulating human mesenchymal stem cell-derived adipogenic cells in either poly (ethylene glycol)-based hydrogel or collagen sponge, and Spinal cord injury-brain ischemic stroke-peripheral nerve damage…”

Section: Applications In Plastic and Reconstructive Surgery And Regenmentioning

confidence: 99%

Immediate cell-supplemented lipotransfer (iCSL)

Condé-Green¹,

Lamblet²

2011

Eur J Plast Surg

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Studies have shown that adipose-derived stem cells may improve neovascularization, graft take, and much more. Many strategies have been developed in the last years to isolate and take advantage of these cells for different applications in many specialties. Immediate cellsupplemented lipotransfer (iCSL) is a reproducible and immediate approach that consists in isolating a great number of stem cells from the harvested fat and injecting the suspension with processed adipose tissue as a scaffold in the same procedure, in a short time and cost-effective manner. In this article, the authors present iCSL throughout its processing method, its advantages and current applications in plastic and reconstructive surgery, and its potential applications in all fields of regenerative medicine

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Section: Applications In Plastic and Reconstructive Surgery And Regenmentioning

confidence: 99%

Immediate cell-supplemented lipotransfer (iCSL)

Condé-Green¹,

Lamblet²

2011

Eur J Plast Surg

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“…Injective transfer of autologous aspirated fat (Matsumoto et al, 2006) is a popular option for tissue augmentation, but several issues limit its clinical application, including unpredictability and a low survival rate because of partial necrosis. An injectable adipocyte filler has been developed from cultured ADSCs (Sajjadian et al, 2007). However, multiple questions remain regarding the viability of ADSCs, the requirement of biological scaffolds, and the repeated injection schedule in the formation of future fat graft replacements.…”

Section: Dermal Augmentation and Adipogenic Differentiation With Adscmentioning

confidence: 99%

A Co-Drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation

Wang

Zhang

et al. 2017

Journal of Investigative Dermatology

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We show that Staphylococcus epidermidis, a commensal bacterium in the human skin microbiome, produces short-chain fatty acids by glycerol fermentation that can induce adipogenesis. Although the antimicrobial and anti-inflammatory activities of short-chain fatty acids have been previously well characterized, little is known about the contribution of short-chain fatty acids to the adipogenic differentiation of adipose-derived stem cells (ADSCs). We show that ADSCs differentiated into adipocytes and accumulated lipids in the cytoplasm when cultured with butyric acid, a principal short-chain fatty acid in the fermentation metabolites of S. epidermidis. Additionally, a co-drug, butyric acid 2-(2-butyryloxyethoxy) ethyl ester (BA-DEG-BA), released active butyric acid when it was intradermally injected into mouse ears and induced ADSC differentiation, characterized by an increased expression of cytoplasmic lipids and perilipin A. The BA-DEG-BA-induced adipogenic differentiation was mediated via peroxisome proliferator-activated receptor gamma. Furthermore, intradermal injection of ADSCs along with BA-DEG-BA into mouse ears markedly enhanced the adipogenic differentiation of ADSCs, leading to dermal augmentation. Our study introduces BA-DEG-BA as an enhancer of ADSC adipogenesis and suggests an integral interaction between the human skin microbiome and ADSCs.

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“…For all of these reasons, ADSCs, in conjunction with tissue engineering, are a promising alternative for soft tissue augmentation. 7…”

Section: Historymentioning

confidence: 99%

Autologous Fat Grafting Viability: Lower Third of the Face

Sykes

Tapias

Pu³

2010

Facial plast Surg

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The process of aging is the result of subcutaneous loss of volume, in addition to vertical tissue descent. Surgeons are therefore emphasizing soft tissue augmentation to achieve a natural, rejuvenated appearance in patients. Autologous fat grafting is now a commonly performed aesthetic procedure. Autologous fat grafting is a challenging procedure, due to the fragile characteristic of adipose tissue. Viability of transplanted fat is a main consideration when fat grafting is performed. Poor fat viability produces an inadequate result and thus can be considered as a complication of this procedure. Many studies have demonstrated that fat longevity is dependent upon handling and preparation of fat. This article outlines the history of autologous fat grafting. The technique of fat grafting is described, along with review of the evidence of fat viability according to the technique used. The specific technique for autologous fat grafting in the lower third of the face is described including augmentation of the labiomandibular fold, lips, chin, and the jaw.

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Treating facial soft tissue deficiency: Fat grafting and adipose-derived stem cell tissue engineering

Abstract: The authors outline the limitations of fat grafting. They then describe the currently available fat culturing technique and explain how options incorporating adipose-derived stem cell technologies and growth factors will provide new modalities in treating facial soft tissue deficiency.

Cited by 17 publications

References 11 publications

Immediate cell-supplemented lipotransfer (iCSL)

Immediate cell-supplemented lipotransfer (iCSL)

A Co-Drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation

Autologous Fat Grafting Viability: Lower Third of the Face

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