Treating Depression: What Patients Want; Findings From a Randomized Controlled Trial in Primary Care

Magnani, Michele; Sasdelli, Anna; Bellino, Silvio; Bellomo, Antonello; Carpiniello, Bernardo; Politi, Pierluigi; Menchetti, Marco; Berardi, Domenico

doi:10.1016/j.psym.2016.05.004

Cited by 12 publications

(10 citation statements)

References 30 publications

(47 reference statements)

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“…It can lead to a possible worsening of the mood, which can trigger suicide attempts due to apparently ineffective therapy and the adverse effects of these drugs. Studies on available antidepressant drugs targeting these pathways report 40% resistance, even with multiple mixed treatments, and 8% persistence without response to any conventional treatment ( Magnani et al, 2016 ).…”

Section: Treatment In Mddmentioning

confidence: 99%

Inflammatory Process and Immune System in Major Depressive Disorder

Ruiz

Ángel

Brizuela

et al. 2021

International Journal of Neuropsychopharmacology

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Major depressive disorder (MDD) is one of the most common psychiatric illnesses in the general population. In mental disorders, the activation of inflammatory pathways in the brain is a major producer of excitotoxicity and an inducer of oxidative stress. The occurrence of these 2 events is partly responsible for the neuronal damage inherent in patients with mental disorders. In the case of MDD, the release of hormone and increase in pro-inflammatory cytokines in plasma and indicators of oxidative stress have been identified as consequences of this event. The most important affectations in patients with MDD are changes in their cognitive and executive functions due to brain inflammation. Hence, these biomarkers can serve as diagnostic and severity classification tools and treatment. In this work, we described the communication pathway between the immune and neuroendocrine systems in MDD and suggested possible therapeutic options for the disease.

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Section: Treatment In Mddmentioning

confidence: 99%

Inflammatory Process and Immune System in Major Depressive Disorder

Ruiz

Ángel

Brizuela

et al. 2021

International Journal of Neuropsychopharmacology

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“…The majority of patients, however, prefer psychological treatments [11, 12, 13•]. In a systematic review of 34 studies among different settings, it was found that on average 75% of patients with mental disorders preferred psychotherapy over drug treatment, especially in younger patients [12], although there are indications that this may be related to severity of depression with more severe patients more often preferring drugs [14].…”

Section: Introductionmentioning

confidence: 99%

Psychological Treatment of Depression in Primary Care: Recent Developments

Cuijpers

Quero

Dowrick

et al. 2019

Curr Psychiatry Rep

170

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Purpose of Review We give an overview of recent developments on psychological treatments of depression in primary care. Recent Findings In recent years, it has become clear that psychotherapies can effectively be delivered through e-health applications. Furthermore, several studies in low and middle income countries have shown that lay health counselors can effectively deliver psychological therapies. Behavioral activation, a relatively simple form of therapy, has been found to be as effective as cognitive behavior therapy. Treatment of subthreshold depression has been found to not only reduce depressive symptoms but also prevent the onset of major depression. In addition, therapies are effective in older adults, patients with general medical disorders and in perinatal depression. Summary Psychological therapies are effective in the treatment of depression in primary care, have longer lasting effects than drugs, are preferred by the majority of patients, and can be applied flexibly with different formats and across different target groups.

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“…Thus, it has been concluded that psychological treatment may be less effective in primary care than in other settings (community self-referrals or specialist mental health care), at least in part, because of the lower motivation associated with the less disabling symptoms among patients in primary care (Cuijpers et al, 2009). Given that treatment preference influences the outcome of interventions, clinical effectiveness reduces commensurately (Dunlop et al, 2012;Magnani et al, 2016). Overall, therefore, differences between populations may have affected the generalizability of the previous studies and meta-analyses.…”

Section: Introductionmentioning

confidence: 99%