Treating depression in HIV-positive patients affects adherence

Moosa, M Y H; Jeenah, F Y

doi:10.4102/sajhivmed.v13i3.128

Cited by 13 publications

(22 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An RCT in South Africa randomized HIV-infected adult patients with clinically diagnosed depression to receive either pharmacological treatment for depression or interpersonal psychotherapy and compared changes in patients’ adherence to patients without depression receiving standard of care [ 89 ]. There were no significant differences between either treatment arm and the control group, or between the two treatment arms.…”

Section: Resultsmentioning

confidence: 99%

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

et al. 2018

View full text Add to dashboard Cite

IntroductionGlobally, an estimated 30% of new HIV infections occur among adolescents (15–24 years), most of whom reside in sub-Saharan Africa. Moreover, HIV-related mortality increased by 50% between 2005 and 2012 for adolescents 10–19 years while it decreased by 30% for all other age groups. Efforts to achieve and maintain optimal adherence to antiretroviral therapy are essential to ensuring viral suppression, good long-term health outcomes, and survival for young people. Evidence-based strategies to improve adherence among adolescents living with HIV are therefore a critical part of the response to the epidemic.MethodsWe conducted a systematic review of the peer-reviewed and grey literature published between 2010 and 2015 to identify interventions designed to improve antiretroviral adherence among adults and adolescents in low- and middle-income countries. We systematically searched PubMed, Web of Science, Popline, the AIDSFree Resource Library, and the USAID Development Experience Clearinghouse to identify relevant publications and used the NIH NHLBI Quality Assessment Tools to assess the quality and risk of bias of each study.Results and discussionWe identified 52 peer-reviewed journal articles describing 51 distinct interventions out of a total of 13,429 potentially relevant publications. Forty-three interventions were conducted among adults, six included adults and adolescents, and two were conducted among adolescents only. All studies were conducted in low- and middle-income countries, most of these (n = 32) in sub-Saharan Africa. Individual or group adherence counseling (n = 12), mobile health (mHealth) interventions (n = 13), and community- and home-based care (n = 12) were the most common types of interventions reported. Methodological challenges plagued many studies, limiting the strength of the available evidence. However, task shifting, community-based adherence support, mHealth platforms, and group adherence counseling emerged as strategies used in adult populations that show promise for adaptation and testing among adolescents.ConclusionsDespite the sizeable body of evidence for adults, few studies were high quality and no single intervention strategy stood out as definitively warranting adaptation for adolescents. Among adolescents, current evidence is both sparse and lacking in its quality. These findings highlight a pressing need to develop and test targeted intervention strategies to improve adherence among this high-priority population.

show abstract

Section: Resultsmentioning

confidence: 99%

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Other studies conducted in sub-Saharan Africa have shown that treating depression improves ART adherence and clinic attendance. [27] , [28] , [29] , [30] Thus, seeking care for depression could have potentially impacted engagement in HIV care through more frequent clinic visits. Although depressed PLHIV were less likely to miss visits throughout the study overall, they also had a lower likelihood of remaining engaged in care by the end of the study.…”

Section: Discussionmentioning

confidence: 99%

Depression and anxiety as barriers to art initiation, retention in care, and treatment outcomes in KwaZulu-Natal, South Africa

et al. 2021

View full text Add to dashboard Cite

“…Among South Africans living in rural communities, the prevalence of mental disorders is reported to be 23.9%, and 4.8%, and depression is one of the major disorder 13 . Moosa and Jeenah 14 have reported a high prevalence of comorbid depression among HIV positive individuals. The HIV infected South African population could then be in danger of added burden of mental disorders in their lives.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Depression among HIV Positive Adults on Anti-Retroviral Therapy in O.R. Tambo, Eastern Cape, South Africa: A cross-sectional descriptive study

Zimasa

Apalata

Abaver³

2020

Preprint

View full text Add to dashboard Cite

Background Living with HIV/AIDS is associated with negative emotional and bodily symptoms; however, there is paucity of data on the prevalence and associated factors depression among this population. This study investigate the prevalence and factors contributing to depression among HIV patients on anti-retroviral therapy (ART) in O.R. Tambo Eastern Cape, South Africa. Method This cross-sectional descriptive study involve 334 adults receiving ART in the two Community Health Centers in OR Tambo District, Eastern Cape, South Africa. The Beck’s Depression Inventory (BDI-II) was used to collect data, in addition to a semi-structured questionnaire on coping mechanism and challenges in seeking help with depressive symptoms. Multiple logistic regression analysis were used to assess the factors associated with depression among the HIV patients. Results The prevalence of depression among the HIV patients receiving ART was 44%, and the majority of the patient’s depression fall within the borderline and moderate threshold. The prevalence of depression was significantly highest among females (71.0%; p < 0.0003) and unemployed (73.0%; p < 0.0014) HIV patients. Participants not benefiting from any form of social grant exhibited higher prevalence of depression (79%). Race (p=0.590), age (p=0.338) and married participants (p=0.511) show no statistical significant association between HIV and depression. Unadjusted logistic regression model show being female (OR = 1.99, 95% CI: 1.23-3.23; p < 0.003) and unemployed (OR =1.73, 95% CI: 1.08-2.77; p < 0.014) were significantly associated with a likelihood of depression. Majority of the participants who could express their feelings of HIV disease and challenges in accessing ART felt more depressed (85%) compared to those who could not express their feelings. Conclusion The rate of depression among HIV/AIDS patients receiving ART is high. Early detection of depression and the challenges associated with accessing treatment and treating would help in improving the compliance to treatment as well as quality of life.

show abstract

Treating depression in HIV-positive patients affects adherence

Abstract: The Joint United Nations Programme on HIV and AIDS recently reported that the number of people newly infected with HIV and the number of AIDS-related deaths are decreasing globally.

Cited by 13 publications

References 68 publications

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature

Depression and anxiety as barriers to art initiation, retention in care, and treatment outcomes in KwaZulu-Natal, South Africa

Prevalence of Depression among HIV Positive Adults on Anti-Retroviral Therapy in O.R. Tambo, Eastern Cape, South Africa: A cross-sectional descriptive study

Contact Info

Product

Resources

About