Treating Aging Changes of Facial Anatomical Layers with Hyaluronic Acid Fillers

Kapoor, Krishan Mohan; Saputra, Deasy Indra; Porter, Catherine Ellen; Colucci, Ligia; Stone, Catherine; Brenninkmeijer, Elian Elisabeth Anne; Sloane, Jake; Sayed, Karim; Winaya, Ketut Kwartantaya; Bertossi, Dario

doi:10.2147/ccid.s294812

Cited by 27 publications

(31 citation statements)

References 71 publications

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“…Definitions of the most common rheologic and physicochemical properties used to characterize HA fillers are provided in Table 1 7 11 14 17 20 24 and discussed in greater depth below.…”

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

“… 11 17 20 HA fillers tend to have low G″. 14 For any HA filler to be effective, it needs to be viscoelastic, i.e., viscous enough to be injected and initially molded, but elastic enough to resist shear deformation forces and provide a durable correction once implanted into soft tissue. 11 17 20 It is important to note that G″ is distinct from viscosity, which relates to the flow of the filler during injection and does not impact clinical performance.…”

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

“… 16 Compression methods, such as the compression force test or the pull-away method, use the rheometer to measure normal force (N) by subjecting the gel to vertical compression (attempting to simulate the compression movements of the face) or positioning the gel between two plates pulled apart at a constant speed. 9 14 17 30 33 34 35 Other cohesivity assays include the drop weight method, wherein an HA gel is pushed through an opening at a constant speed and its weight is determined, and the visual shear-stressed gel method, which is based on physical handling of the gel. 34 35 …”

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

“…In areas of the upper face where filling and volume restoration are required, as in the temporal fossa, 14 38 39 40 41 the HA filler should have high elasticity or resistance to deformation (G′) and medium to high cohesivity. To address forehead contour, the filler chosen should have a medium to high G′ and a low to medium cohesivity, 42 which would allow for molding and some degree of spread upon injection.…”

Section: Selecting the Appropriate Ha Filler Based On Its Rheologic A...mentioning

confidence: 99%

“…Understanding the range of HA filler products from the standpoint of their rheologic and physicochemical characteristics can provide an initial framework for predicting treatment outcomes 13 and assist clinicians in selecting the appropriate attributes for each treated facial area. 11 14 Rheologic and physicochemical properties of HA fillers impact performance characteristics (i.e., lift capacity, resistance to deformation, and tissue integration), which, together with injection technique (i.e., injection plane, location, volume) and the interaction of the filler with the surrounding tissue, may affect clinical outcomes. 15 …”

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confidence: 99%

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Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Guardia

Virno²,

Musumeci

et al. 2022

Facial Plast Surg

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Injections with hyaluronic acid (HA) fillers for facial rejuvenation and soft-tissue augmentation are among the most popular aesthetic procedures worldwide. Many HA fillers are available with unique manufacturing processes and distinct in vitro physicochemical and rheologic properties, which result in important differences in the fillers' clinical performance. The aim of this paper is to provide an overview of the properties most widely used to characterize HA fillers and to report their rheologic and physicochemical values obtained using standardized methodology to allow scientifically based comparisons. Understanding rheologic and physicochemical properties will guide clinicians in aligning HA characteristics to the facial area being treated for optimal clinical performance.

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“…Definitions of the most common rheologic and physicochemical properties used to characterize HA fillers are provided in Table 1 7 11 14 17 20 24 and discussed in greater depth below.…”

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

Section: Overview Of the Rheologic And Physicochemical Characteristic...mentioning

confidence: 99%

Section: Selecting the Appropriate Ha Filler Based On Its Rheologic A...mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Guardia

Virno²,

Musumeci

et al. 2022

Facial Plast Surg

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Advanced Bioadhesive Hydrogels for Skin Care and Therapy

Han

Cho

2023

Advanced Therapeutics

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Hydrogels are a frequently utilized and modified biomaterial. Due to their unique tissue‐like properties, they are used in various biomedical applications. Among the many types of hydrogels, bioadhesive hydrogels are of particular interest, as they provide long‐term robust tissue adhesion that aids in therapeutic applicability, including drug delivery, mechanical stimulus, and in situ monitoring and diagnosis. Accordingly, this review highlights recent developments in bioadhesive hydrogels and their dermatological applications. To provide a broader view of bioadhesive hydrogels, studies regarding their assistance in skin diagnosis and the corresponding treatments are also summarized. This review comprehensively explains the importance and versatility of advanced and unique therapeutic bioadhesive hydrogels used in skin care and therapy.

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Hydrogels in the clinic: An update

Clegg,

Adebowale,

Zhao

et al. 2024

Bioengineering & Transla Med

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Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas. The past three decades have witnessed rapid advances in the fields of polymer chemistry, crosslinking approaches, and hydrogel fabrication methods, which have collectively brought many new hydrogel products, either injectable or non‐injectable, to clinical studies. In an article published in 2020 entitled “Hydrogels in the clinic”, we reviewed the clinical landscape and translational challenges of injectable hydrogels. Here, we provide an update on the advances in the field and also extend the scope to include non‐injectable hydrogels. We highlight recently approved hydrogel products, provide an update on the clinical trials of injectable hydrogels, and discuss active clinical trials of topically applied and implantable hydrogels.

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Treating Aging Changes of Facial Anatomical Layers with Hyaluronic Acid Fillers

Cited by 27 publications

References 71 publications

Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Rheologic and Physicochemical Characteristics of Hyaluronic Acid Fillers: Overview and Relationship to Product Performance

Advanced Bioadhesive Hydrogels for Skin Care and Therapy

Hydrogels in the clinic: An update

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