Treating a Global Health Crisis with a Dose of Synthetic Chemistry

Hardy, Melissa A.; Wright, Brandon A.; Bachman, James L; Boit, Timothy B.; Haley, Hannah M. S.; Knapp, Rachel R.; Lusi, Robert; Okada, Taku; Tona, Veronica; Garg, Neil K.; Sarpong, Richmond

doi:10.1021/acscentsci.0c00637

Cited by 27 publications

(23 citation statements)

References 146 publications

(174 reference statements)

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“…For this matter, access to a large synthetic toolbox, full of efficient and robust stereoselective technologies, is essential. 15 These synthetic tools have to meet increasingly higher demands due to a rise in complexity of marketed drugs. 16,17 While many of the initial anti-viral drugs were nucleoside analogues based on (deoxy)sugar building blocks from the chiral pool or simply non-chiral, novel anti-viral drugs are often more complex, multicyclic or macrocyclic, and possess multiple chiral centres that are difficult to install.…”

Section: Wolf-dieter Fessnermentioning

confidence: 99%

Biocatalytic routes to anti-viral agents and their synthetic intermediates

Slagman

Fessner

2021

Chem. Soc. Rev.

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Section: Wolf-dieter Fessnermentioning

confidence: 99%

Biocatalytic routes to anti-viral agents and their synthetic intermediates

Slagman

Fessner

2021

Chem. Soc. Rev.

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“…There have been several reviews published recently on COVID‐19 addressing the recent advancement on the analysis, testing and treatment of this virus [10–43] . In this review, we have discussed COVID‐19 facts and literature starting from host binding events of SARS‐CoV‐2, chemical preventive measures and synthesis of repurposed drugs into chemical science perspective.…”

Section: Introductionmentioning

confidence: 99%

“…[1,8,9] Personal preventive measures [10] including chemical protective measures such as soap water, bleach solution, alcohol-based hand sanitizers, and hydrogen peroxide have been conceptualized and prepared to destroy the viruses. [11] Advancement of various testing tools, [12][13][14][15][16][17][18][19] antiviral drugs, [20][21][22][23][24][25][26][27][28][29] vaccines, [30][31][32] and other medical involvements [10] are being developed in a fast-paced manner. These activities apparently seem far away from the areas of chemistry which usually deal with elements and chemical compounds.…”

Section: Introductionmentioning

confidence: 99%

COVID‐19 into Chemical Science Perspective: Chemical Preventive Measures and Drug Development

Adhikari

Sahu

2021

ChemistrySelect

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COVID‐19 facts and literature are discussed into chemical science intuition highlighting the direct role of chemistry to the ongoing global pandemic by covering structural identification of the virus, chemical preventive measures and development of drugs. We reviewed the four most promising repurposed drugs which are presently being investigated in mass clinical trials on COVID‐19 infected persons and synthetic routes of these drugs with their recent advancement. Chemical preventive measures such as soap water, hand sanitizer and disinfectant are the only available options in the arsenal to fight against COVID‐19, till an effective medicine or vaccine will be made available. As such the present review will focus on the mode of action of the major chemical preventives.

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“…The optimization of reactions used to synthesize target compounds is pivotal to chemical research and discovery, whether in developing a route for manufacturing a life-saving medicine 1 or unlocking the potential of a new material 2 . But reaction optimization requires iterative experiments to balance the often conflicting effects of numerous coupled variables, and frequently involves finding the sweet spot among thousands of possible sets of experimental conditions.…”

mentioning

confidence: 99%