Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents

Nowakowski, Patryk; Markiewicz‐Żukowska, Renata; Bielecka, Joanna; Mielcarek, Konrad; Grabia, Monika; Socha, Katarzyna

doi:10.1016/j.biopha.2021.112106

Cited by 33 publications

(20 citation statements)

References 213 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the NCI and the NCCIH, they can improve HR-QoL and immunomodulation. Moreover, they have been approved as adjuncts to standard cancer treatment in Japan and China more than 30 years ago and have an extensive history of safe clinical use alone or combined with RT or AC ( Roda et al, 2020 ; Barbieri et al, 2017 ; Nowakowski et al, 2021 ). The different blends produce numerous bioactive compounds that influence several cancer-related pathways, often synergistically, also by modulating the cellular targets involved in cell proliferation, survival, and angiogenesis ( Barbieri et al, 2017 ; Rossi et al, 2018 ; Garau et al, 2021 ; Nowakowski et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Improved Survival and Quality of Life Through an Integrative, Multidisciplinary Oncological Approach: Pathophysiological Analysis of Four Clinical Cancer Cases and Review of the Literature

Berretta

Morra²,

Taibi

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Objectives: According to the National Cancer Institute, the integrative medicine (IM) approach to medical care combines standard medicine with complementary and alternative medicine practices that have proved safe and effective.Methods: We describe the clinical cases of four patients with malignant pleural mesothelioma (MPM), diffuse malignant peritoneal mesothelioma (DMPM), intrahepatic cholangiocarcinoma, and breast cancer (BC) who received supportive treatment (ST) according to an IM approach after the failure of standard cancer treatments or the appearance of serious adverse events caused by antiblastic chemotherapy. The critical role of complementary drugs in reducing the side effects of cancer treatments and normalizing the white cell count is especially apparent in the case of the patient with metastatic BC, who experienced prolonged neutropenia.Results: The IM approach was well-tolerated and had no adverse side effects. It improved the quality of life (QoL) of all patients and in two cases extended overall survival.Conclusion: The extended clinical and instrumental response to IM of the patients with malignant mesothelioma and the improved health-related QoL and good tolerance of the ST demonstrated in all cases support the value of this approach in patients whose cancer therapies have failed but who show a good performance status. Our data require confirmation in a well-designed prospective clinical trial.

show abstract

Section: Discussionmentioning

confidence: 99%

Improved Survival and Quality of Life Through an Integrative, Multidisciplinary Oncological Approach: Pathophysiological Analysis of Four Clinical Cancer Cases and Review of the Literature

Berretta

Morra²,

Taibi

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…p53 is increased under stimulation, and then upregulates the expression of pro-apoptotic genes (Eliaš and Macnamara, 2021). SUMOylated p53 could bind to the antiapoptotic factor Bax and Bcl-2, and lead to apoptosis (Nowakowski et al, 2021). SENP1 deficiency significantly increases podocyte apoptosis by increasing expression of the p53 target pro-apoptotic genes (Noxa, PUMA and BAX) and aggravating accumulation of SUMOylated p53 protein in puromycin aminonucleoside-induced podocyte injury (Wang et al, 2014b).…”

Section: P53 Pathwaysmentioning

confidence: 99%

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

et al. 2022

View full text Add to dashboard Cite

Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development of renal fibrosis. Recent advances suggest that SUMOylation functions as the promising intervening target against renal fibrosis, and natural products prevent renal fibrosis via modulating SUMOylation. Here, we introduce the mechanism of SUMOylation in renal fibrosis and therapeutic effects of natural products. This process starts by summarizing the key mediators and enzymes during SUMOylation and deSUMOylation and its regulation role in transcriptional factors and key mediators in renal fibrosis, then linking the mechanism findings of SUMOylation and natural products to develop novel therapeutic candidates for treating renal fibrosis, and concludes by commenting on promising therapeutic targets and candidate natural products in renal fibrosis via modulating SUMOylation, which highlights modulating SUMOylation as a promising strategy for natural products against renal fibrosis.

show abstract

“…Nowakowski and colleagues have summarized 92 mushroom species with antineoplastic activity, which could be effective against 38 various cancers [ 355 ]. Mushrooms display a great number of secondary metabolites with different biological activities [ 356 , 357 , 358 ].…”

Section: Mushroomsmentioning

confidence: 99%

“…Among others, shiitake chemical composition includes polysaccharides, polysaccharopeptides, lectinss, and lentinan, the last of which is especially focused on the medical attributes of this mushroom [ 355 ].…”

Section: Mushroomsmentioning

confidence: 99%

“…Several big company sale food supplements contain, or are fully derived from, mushrooms. For instance, iHerb (USA, California, www.iherb.com; accessed on 30 Nowakowski and colleagues have summarized 92 mushroom species with antineoplastic activity, which could be effective against 38 various cancers [355]. Mushrooms display a great number of secondary metabolites with different biological activities [356][357][358].…”

Section: Mushroomsmentioning

confidence: 99%

See 1 more Smart Citation

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

et al. 2022

View full text Add to dashboard Cite

Traditional herbal medicine (THM) is a “core” from which modern medicine has evolved over time. Besides this, one third of people worldwide have no access to modern medicine and rely only on traditional medicine. To date, drugs of plant origin, or their derivates (paclitaxel, vinblastine, vincristine, vinorelbine, etoposide, camptothecin, topotecan, irinotecan, and omacetaxine), are very important in the therapy of malignancies and they are included in most chemotherapeutic regimes. To date, 391,000 plant and 14,000 mushroom species exist. Their medical and biochemical capabilities have not been studied in detail. In this review, we systematized the information about plants and mushrooms, as well as their active compounds with antitumor properties. Plants and mushrooms are divided based on the regions where they are used in ethnomedicine to treat malignancies. The majority of their active compounds with antineoplastic properties and mechanisms of action are described. Furthermore, on the basis of the available information, we divided them into two priority groups for research and for their potential of use in antitumor therapy. As there are many prerequisites and some examples how THM helps and strengthens modern medicine, finally, we discuss the positive points of THM and the management required to transform and integrate THM into the modern medicine practice.

show abstract

Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents

Cited by 33 publications

References 213 publications

Improved Survival and Quality of Life Through an Integrative, Multidisciplinary Oncological Approach: Pathophysiological Analysis of Four Clinical Cancer Cases and Review of the Literature

Improved Survival and Quality of Life Through an Integrative, Multidisciplinary Oncological Approach: Pathophysiological Analysis of Four Clinical Cancer Cases and Review of the Literature

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

How Should the Worldwide Knowledge of Traditional Cancer Healing Be Integrated with Herbs and Mushrooms into Modern Molecular Pharmacology?

Contact Info

Product

Resources

About