Treasure from garden: chemical profiling, pharmacology and biotechnology of mulleins

HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of Verbascum ovalifolium Donn ex Sims and evaluation of its antioxidant and cytogenotoxic activities

“…Iridoid glycosides are the largest group of secondary metabolites found in Verbascum genus, with more than 70 iridoid glycosides being identified in the flowers, leaves and roots of these species; among them catalpol‐type derivatives are the most frequent . HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS profiling of CME obtained from the aerial parts of V. ovalifolium and its fractions revealed the presence of 28 iridoid glycosides.…”

“…Verbascum species (mulleins) are very well‐known herbs used since ancient times in traditional folk medicine as oral or topic remedies for coughs, bronchitis, asthma, hemorrhoids, migraine, wounds and eczema . In many European countries, mullein flowers are marketed, alone or in combination, as herbal pharmaceutical preparations (herbal teas, alcoholic and aqueous extracts, syrups, tablets) mainly for respiratory tract infections .…”

“…Verbascum genus, that comprises about 360 species worldwide, is acknowledged nowadays as a rich source of bioactive constituents, such as: phenolic compounds (phenylethanoids, flavonoids, neolignan glycosides, phenolic acids), iridoids, saponins and polysaccharides with reported antioxidant, anti‐inflammatory, antibacterial, anti‐tumour and anticholinesterasic properties . To date, liquid chromatography‐mass spectrometry (LC–MS) techniques were employed for identifying and/or quantifying mostly flavonoids and phenolic acids from Verbascum extracts, although it is acclaimed that iridoid and phenylethanoid glycosides are the most abundant constituents that contribute in an important extent to the efficacy of mullein products .…”

The diversity of endophytic fungi in Verbascum lychnitis from industrial areas

“…This mullein species was earlier investigated for the presence of bioactive compounds (Alipieva et al 2014) or in studies on succession (Rebele 2008). The most frequent genera isolated from V. lychnitis were typical endophytes inhabiting other monocotyledonous and dicotyledonous plants.…”

Natural products utilization

“…The growing importance of medicinal plants is illustrated by a set of comprehensive reviews on Astragalus (Fabaceae), Verbascum (Scrophulariaceae), Lamium and Agastache (Lamiaceae), their bioactive principles and record accomplishment in traditional use (Alipieva et al 2014;Ionkova et al 2014;Yordanova et al 2014;Zielińska and Matkowski 2014). Nasopoulou et al (2014) focuses on the opportunity to utilize the by-products of olive oil production (e.g.…”