Treadmill training improves respiratory function in rats after spinal cord injury by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway

Tang, Dan; Wang, Xianbin; Chen, Yuan; Yang, Xianglian; Hu, Shouxing; Song, Ning; Jia, WANG; Cheng, Jiawen; Wu, Shuang

doi:10.1016/j.neulet.2022.136686

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…The effects of exercise training are multifaceted and intricate, impacting various aspects of the central nervous system. As a main clinical strategy in rehabilitation medicine, it has been widely proven that exercise training positively affects the circadian rhythm, central metabolism, cardiovascular function, and stress responses of the CNS [ 37 – 40 ]. However, the benefit of exercise training may relate to specific forms and training intensity.…”

Section: Discussionmentioning

confidence: 99%

Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

Wang,

Su,

Zhong

et al. 2023

Mol Biomed

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In this study, we examined the combined impact of osteopontin (OPN) and treadmill training on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP into the sensorimotor cortex, followed by a left incomplete C5 crush injury two weeks later. Mice (Ex or Ex + OPN group) were trained at 50% maximum running speed for 8 weeks. To analyze the effects, we used biotinylated dextran amine (BDA) for tracing the corticospinal tract (CST) and performed Western blotting and immunohistochemical methods to assess the activation of the mammalian target of rapamycin (mTOR). We also examined axonal regeneration and conducted behavioral tests to measure functional recovery. The results demonstrated that treadmill training promoted the expression of neurotrophic factors such as brain-derived neurotrophic factor (BNDF) and insulin-like growth factor I (IGF-1) and activated mTOR signaling. OPN amplified the effect of treadmill training on activating mTOR signaling indicated by upregulated phosphorylation of ribosomal protein S6 kinase (S6). The combination of OPN and exercise further promoted functional recovery and facilitated limited CST axonal regeneration which did not occur with treadmill training and OPN treatment alone. These findings indicate that OPN enhances the effects of treadmill training in the treatment of SCI and offer new therapeutic insights for spinal cord injury.

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Section: Discussionmentioning

confidence: 99%

Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

Wang,

Su,

Zhong

et al. 2023

Mol Biomed

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show abstract

“…AT can also increase endurance by improving the efficiency of the cardiovascular system, allowing individuals with SCI to perform daily activities and exercise for longer periods of time [ 14 , 20 ]. Finally, AT can improve respiratory function by increasing lung capacity and strengthening respiratory muscles, which can improve breathing and reduce the risk of respiratory infections [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

A three-arm randomized controlled trial of aerobic and resistance training in women with spinal cord injuries: Effects on physical fitness and pulmonary function

Haghighi,

Ahmadi,

Askari

et al. 2024

Heliyon

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Motor rehabilitation as a therapeutic tool for spinal cord injury: New perspectives in immunomodulation

Walsh¹,

Gull²,

Dooley³

2023

Cytokine & Growth Factor Reviews

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Treadmill training improves respiratory function in rats after spinal cord injury by inhibiting the HMGB1/TLR-4/NF-κB signaling pathway

Cited by 3 publications

References 36 publications

Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury

A three-arm randomized controlled trial of aerobic and resistance training in women with spinal cord injuries: Effects on physical fitness and pulmonary function

Motor rehabilitation as a therapeutic tool for spinal cord injury: New perspectives in immunomodulation

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