Treadmill exercise reduces obestatin concentrations in rat fundus and small intestine

Ghanbari–Niaki, Abbass; Jafari, Akram; Abednazari, Hossein; Nikbakht, Hojatollah

doi:10.1016/j.bbrc.2008.05.097

Cited by 16 publications

(14 citation statements)

References 37 publications

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“…30 A single circuit-resistance exercise had no effect on plasma obestatin levels in female college students; however, the authors reported that GH levels increased significantly and concluded that obestatin, likewise acyl-ghrelin, does not contribute to circuit-resistance exercise-induced increase in GH. 31 Aerobic exercise in healthy women found no changes in plasma obestatin after 24 h, 48 h and 7 days 32 but an experimental study in rats showed decreased obestatin levels in fundus and small intestine after aerobic exercise for 6 weeks. 31 There are many contradictory reports about exercise effects on acyl-ghrelin and obestatin.…”

Section: Discussionmentioning

confidence: 98%

“…31 Aerobic exercise in healthy women found no changes in plasma obestatin after 24 h, 48 h and 7 days 32 but an experimental study in rats showed decreased obestatin levels in fundus and small intestine after aerobic exercise for 6 weeks. 31 There are many contradictory reports about exercise effects on acyl-ghrelin and obestatin. However, it must be considered that HD present many clinical conditions that may alter the hormones physiology.…”

Section: Discussionmentioning

confidence: 98%

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Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

et al. 2015

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Chronic physical exercises may be beneficial to modulate appetite hormones as acyl-ghrelin (orexigenic) and obestatin (anorexigenic) in chronic kidney disease (CKD) patients; however, there are no data about the effects of acute exercises on these hormones. Thus, the aim of the present study was to assess the effect of acute resistance exercise on appetite hormones (acylghrelin and obestatin) of patients undergoing hemodialysis (HD). Twenty-five patients (44.7 ± 12.9 years, 68% women) on regular HD program were enrolled into two groups, 16 patients performed exercises and 9 patients comprised the control group. The patients performed the exercises in both lower limbs with ankle-cuffs and elastic bands, 30 min after the initiation of hemodialysis session. Blood samples of both the groups were drawn in the morning before and after 30 min with exercise session (exercise group) and, before and after the same time without exercise (control group). Acyl-ghrelin and obestatin plasma levels were measured using an enzyme immunometric assay. Acyl-ghrelin plasma levels did not change in both the groups. However, when stratified by gender the acyl-ghrelin increased significantly right after exercise in men [32.1 pg/mL (25.6-41.2) to 46.0 pg/mL (39.0-59.5)] (p ¼ 0.04). Obestatin plasma levels reduced after a single bout of exercise and changes remained significantly when the sample was stratified by gender. There was no change in obestatin plasma levels in control group. A single bout of resistance exercise seems to modulate the levels of appetite hormones in HD patients.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

et al. 2015

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“…In patients with anorexia or post-bariatric surgery, profound changes in plasma ghrelin levels were found, suggesting that it is an important hormone in the regulation of body weight (Gaddipati et al 2006;Jürimäe et al 2007). Studies on the effects of acute or chronic exercise showed that high-intensity exercise could lower plasma ghrelin levels in rats (Ghanbari-Niaki et al 2008;Wang et al 2008;GhanbariNiaki et al 2009). Nevertheless, the effects of mild to moderate exercise on plasma ghrelin levels in animals remain unknown.…”

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confidence: 99%

Vagal Nerve Regulation Is Essential for the Increase in Gastric Motility in Response to Mild Exercise

Wang

Kondo

Suzukamo

et al. 2010

Tohoku J. Exp. Med.

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It has been shown that mild to moderate exercise can accelerate gastric emptying in humans. However, understanding of the underlying mechanism is hampered by the lack of appropriate animal models. To investigate the effects of mild exercise on gastric motility, we developed an animal model, in which strain gauge transducers were surgically planted on the antral surfaces of female Sprague-Dawley rats. We continuously recorded the contractions of gastric circular muscle in unrestrained conscious rats, divided into four groups: sham-operated exercise, sham-operated sedentary, vagotomized exercise, and vagotomized sedentary. The rats were trained for 3 weeks, and gastric motility was monitored before and after exercise. Although exercise accelerates gastric antral contraction in sham-operated rats, this effect was absent in the vagotomized exercise group, indicating the involvement of the vagal nerve in the exercise-mediated increase in gastric motility. Among the four groups, daily food intake was highest in the sham-operated exercise group. In contrast, the vagotomized exercise group exhibited the smallest body weight gain. Severe gastric retention was observed in vagotomized rats, suggesting a role of the vagal nerve in facilitating food movement and digestion in the stomach. Moreover, at the end of the 3-week exercise, there were no differences in plasma levels of growth hormone, peptid YY, and ghrelin among the four groups. These results indicate that in response to a mild physical exercise challenge, the vagal nerve stimulates gastric motility and enhances the ability of the stomach to process food. Our findings highlight the significance of neuronal control of stomach function.

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“…One study showed that plasma obestatin levels decreased after intervention with physical exercise; on the other hand, another study found no changes after intervention with physical exercises. 11,12 To date, there is no publication about the effects of resistance exercise in acylghrelin and obestatin levels in CKD patients undergoing HD. Therefore, the purpose of this study was to analyze the effect of resistance exercise training program (RETP) on acylghrelin and obestatin levels in patients undergoing hemodialysis (HD).…”

Section: Introductionmentioning

confidence: 99%

Effects of resistance exercise training on acyl-ghrelin and obestatin levels in hemodialysis patients

et al. 2015

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Background: Patients undergoing hemodialysis (HD) present altered levels of appetite hormones such as acyl-ghrelin (orexigenic) and obestatin (anorexigenic), which may contribute to anorexia. Physical exercise may affect these hormones and improve appetite in these patients. Objectives: The objective of this study is to evaluate the effects of a resistance exercise program in appetite hormones, body composition, and nutritional status in HD patients. Design: Intervention study with the control group. Subjects: Fifty-two patients on regular HD program were enrolled into two groups: 37 patients performed exercises (56.7% male, 45 ± 12.8 years, 57 (9-192) months on HD) and 15 patients comprised the control group (66.7% men, 50 ± 10.6 years, 57 (11-153) months on HD). Measurements: Exercise program (performed with elastic bands and ankle cuffs in both lower limbs) was supervised three times a week during 6 months (72 sessions). Patients had their blood drawn in a regular HD day after overnight fasting, before and after 6 months of exercise program. Obestatin, acyl-ghrelin, routine biochemical parameters, quality of life, and anthropometric data were collected and analyzed before and after 6 months. Results: After 6 months of exercise, obestatin levels reduced [from 3.0 ng/mL (2.3-3.4) to 1.9 ng/mL (0.6-3.4)] and acyl-ghrelin levels increased [from 21.5 pg/mL (1.3-77.7) to 37.2 pg/mL (16.7-94.1)] and the control group presented no significant differences in both plasma levels of hormones. Body composition and physical functional assessed by SF-36 and albumin levels (3.7 ± 0.3 to 3.9 ± 0.2, p50.05) improved after exercises. Conclusion: Six months of resistance exercises contributed to changes in plasma appetite hormones, body composition, and nutritional status in hemodialysis patients.

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Treadmill exercise reduces obestatin concentrations in rat fundus and small intestine

Cited by 16 publications

References 37 publications

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Effects of acute resistance exercise on acyl-ghrelin and obestatin levels in hemodialysis patients: a pilot study

Vagal Nerve Regulation Is Essential for the Increase in Gastric Motility in Response to Mild Exercise

Effects of resistance exercise training on acyl-ghrelin and obestatin levels in hemodialysis patients

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