Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Luo, Zhihua; Dai, Yelin; So, Kwok-Fai; Zhang, Li

doi:10.1038/s42003-023-05003-w

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…To date, sufficient experimental evidence supports its role in governing depression and anxiety (Lim et al, 2021). Luo et al (2023) claimed that exercise can effectively alleviate mental disorders, including anxiety and depression, and its neural mechanism can be attributed to improvements in AN. Nonetheless, the mechanism underlying PA-induced AN has not been determined so far.…”

Section: Discussionmentioning

confidence: 99%

Research status and trends of physical activity on depression or anxiety: a bibliometric analysis

Zhang,

Ye,

Yin

et al. 2024

Front. Neurosci.

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BackgroundAnxiety and depression are prevalent mental disorders. As modern society continues to face mounting pressures, the incidence of anxiety and depression is on the rise. In recent years, there has been an increasing breadth of research exploring the relationship between anxiety, depression, and physical activity (PA). However, the current research progress and future development trends are unclear. The purpose of this study is to explore the research hotspots and development trends in this field, and to provide guidance for future studies and to provide some reference for clinicians.MethodsWe searched the relevant literature of Web of Science Core Collection from the establishment of the database to August 15, 2023. CiteSpace, VOSviewer and Bibliometrix Packages based on the R language were used to analyze the number of publications, countries, institutions, journals, authors, references, and keywords.ResultsA total of 1,591 studies were included in the analysis, and the research in the field of PA on anxiety or depression has consistently expanded. The USA (304 publications), Harvard University (93 publications), and the journal of affective disorders (97 publications) were the countries, institutions, and journals that published the highest number of articles, respectively. According to the keywords, students and pregnant women, adult neurogenesis, and Tai Chi were the groups of concern, physiological and pathological mechanisms, and the type of PA of interest, respectively.ConclusionThe study of PA on anxiety or depression is experiencing ongoing expansion. Clinicians can consider advising patients to take mind–body exercise to improve mood. In addition, future researchers can explore the mind–body exercise and its impact on anxiety or depression, PA and anxiety or depression in specific populations, and adult neurogenesis of various exercise in anxiety or depression.

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Section: Discussionmentioning

confidence: 99%

Research status and trends of physical activity on depression or anxiety: a bibliometric analysis

Zhang,

Ye,

Yin

et al. 2024

Front. Neurosci.

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“…Positioning was performed according to the stereotaxic atlas. After confirming that the anterior and posterior fontanelles were on the same horizontal line, the anterior bregma was taken as the zero point, and the following injection sites were selected: mPFC (AP2.0 mm, ML+0.2 mm, DV-2.0 mm) ( 30 ). Four microliters of sterile cerebrospinal fluid (the ingredient ratios are shown in Table 1 ) or IL-17A antibody were drawn up with a 5 µl microsyringe and injected at a rate of 0.42 µl/min.…”

Section: Methodsmentioning

confidence: 99%

Transcutaneous auricular vagus nerve stimulation improves social deficits through the inhibition of IL-17a signaling in a mouse model of autism

Zhang,

Mou,

Zhong

et al. 2024

Front. Psychiatry

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BackgroundMaternal exposure to inflammation is one of the causes of autism spectrum disorder (ASD). Electrical stimulation of the vagus nerve exerts a neuroprotective effect via its anti-inflammatory action. We thus investigated whether transcutaneous auricular vagus nerve stimulation (taVNS) can enhance social abilities in a mouse model of ASD induced by maternal immune activation (MIA).MethodsASD mouse model were constructed by intraperitoneal injection of polyinosinic:polycytidylic acid (poly (I:C)). TaVNS with different parameters were tested in ASD mouse model and in C57BL/6 mice, then various behavioral tests and biochemical analyses related to autism were conducted. ASD model mice were injected with an interleukin (IL)-17a antibody into the brain, followed by behavioral testing and biochemical analyses.ResultsTaVNS reduced anxiety, improved social function, decreased the number of microglia, and inhibited M1 polarization of microglia. Additionally, taVNS attenuated the expression of the IL-17a protein in the prefrontal cortex and blood of ASD model mice. To examine the possible involvement of IL-17a in taVNS-induced neuroprotection, we injected an IL-17a antibody into the prefrontal cortex of ASD model mice and found that neutralizing IL-17a decreased the number of microglia and inhibited M1 polarization. Furthermore, neutralizing IL-17a improved social function in autism model mice.ConclusionOur study revealed that reduced neuroinflammation is an important mechanism of taVNS-mediated social improvement and neuroprotection against autism. This effect of taVNS could be attributed to the inhibition of the IL-17a pathway.

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“…Both exercise modalities promote neuroplastic changes in the depressed brain. Specifically, the positive effects of TE have been attributed to increased volume and enhanced maturation of the newborn, dendritic spine density, and axonal myelination in the HIP and medial prefrontal cortex (mPFC), whereas similar effects in the HIP, basolateral amygdala (BLA), and NAc have also been demonstrated in a stress-induced depression model ( 49 , 50 , 56 , 58 ). These structural changes in the brain subregions, which are associated with emotional processing and possibly regulating susceptibility and resilience to stress, contribute to the observed improvements in depressive-and anxiety-like behaviors ( 64 ).…”

Section: Exercise-induced Antidepressant Effect In Depression Modelmentioning

confidence: 99%

Exercise as an antidepressant: exploring its therapeutic potential

Hwang,

Koo,

Kim

et al. 2023

Front. Psychiatry

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The COVID-19 pandemic has increased the prevalence of depressive disorders worldwide, requiring alternative treatments beyond medication and psychotherapy. Exercise has positive effects on the brain; therefore, it has emerged as a promising therapeutic option for individuals with depression. Considerable research involving humans and animals offers compelling evidence to support the mental health benefits of physical activity or exercise mediated by the regulation of complex theoretical paradigms. However, challenges such as conducting long-term follow-up assessments and considering individual characteristics remain in human studies despite extensive efforts. While animal studies provide valuable insights into the potential benefits of exercise and its impact on outcomes related to depression and anxiety in rodents exposed to different stress paradigms, translating the findings to humans requires careful evaluation. More research is needed to establish precise exercise prescription guidelines and to better understand the complex relationship between exercise and depressive disorders. Therefore, this concise review explores the evidence supporting exercise intervention as an antidepressant treatment and its underlying mechanisms.

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Treadmill exercise modulates the medial prefrontal-amygdala neural circuit to improve the resilience against chronic restraint stress

Cited by 7 publications

References 45 publications

Research status and trends of physical activity on depression or anxiety: a bibliometric analysis

Research status and trends of physical activity on depression or anxiety: a bibliometric analysis

Transcutaneous auricular vagus nerve stimulation improves social deficits through the inhibition of IL-17a signaling in a mouse model of autism

Exercise as an antidepressant: exploring its therapeutic potential

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