“…6 During the following decades, the idea of reducing dialysis treatment time by simply increasing the physical performance of the dialyzer became obsolete and was controversially discussed, based on observed long-term complications. 7,8 With the advent of high-volume hemodiafiltration with substitution volumes of more than 20 L while using high-flux dialyzers and high blood flows, the original ideas of Beat von Albertini received a late confirmation. Due to a better patient survival with high substitution volume as the new term for “dialysis dose,” this technology is currently gaining more and more acceptance in the nephrological community.…”