Trazodone for the Treatment of Sexual Dysfunction Induced by Serotonin Reuptake Inhibitors

Stryjer, Rafael; Spivak, Baruch; Strous, Rael D.; Shiloh, Roni; Harary, Eran; Polak, Lea; Birgen, Margarita; Kotler, Moshe; Weizman, Abraham

doi:10.1097/wnf.0b013e31816d1cdc

Cited by 47 publications

(22 citation statements)

References 14 publications

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“…In a pilot study, it was observed that trazodone may be beneficial in the management of selective serotonin-reuptake inhibitor-induced sexual dysfunction (Stryjer et al, 2009). In men with ED and a degree of psychogenic component sufficient to reduce the efficacy of medical management, a combination of trazodone with sildenafil gave promising results in a pilot study (Taneja, 2007).…”

Section: Drugs For Nonintracavernosal Administrationmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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Section: Drugs For Nonintracavernosal Administrationmentioning

confidence: 99%

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

2011

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“…For men taking an SSRI, 20 mg of tadalafil has been shown to significantly improve erectile function, with tolerable side effects [44]. Trazodone has also proven to be effective in treating ED in men taking SSRIs [45]. …”

Section: Resultsmentioning

confidence: 99%

Organic Causes of Erectile Dysfunction in Men Under 40

Ludwig

Phillips²

2013

Urol Int

1,562

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There are a significant number of men under 40 who experience erectile dysfunction (ED). In the past, the vast majority of cases were thought to be psychogenic in nature. Studies have identified organic etiologies in 15-72% of men with ED under 40. Organic etiologies include vascular, neurogenic, Peyronie's disease (PD), medication side effects and endocrinologic sources. Vascular causes are commonly due to focal arterial occlusive disease. Young men with multiple sclerosis, epilepsy and trauma in close proximity to the spinal cord are at increased risk of ED. It is estimated that 8% of men with PD are under 40, with 21% of these individuals experiencing ED. Medications causing ED include antidepressants, NSAIDs and finasteride (Propecia), antiepileptics and neuroleptics. Hormonal sources are uncommon in the young population, however possible etiologies include Klinefelter's syndrome, congenital hypogonadotropic hypogonadism, and acquired hypogonadotropic hypogonadism. The workup of young men with ED should include a thorough history and physical examination. The significant prevalence of vascular etiologies of ED in young men should prompt consideration of nocturnal penile tumescence testing and penile Doppler ultrasound. Treatment options that may improve ED include exercise and oral PDE-5 inhibitors.

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“…Specific differences in men and women were improvement in erectile performance in men and lubrication in women. No correlations were noted between clinical improvement of depression or anxiety and improvement in sexual dysfunction [Stryjer et al 2009]. …”

Section: Discussionmentioning

confidence: 99%

Study of effects of selective serotonin reuptake inhibitors on stages of sexual function in Iranian patients with major depressive disorder

Safa

Sadr

Talischi

et al. 2013

Therapeutic Advances in Psychopharmacology

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Celsus described depression as a consequence of black bile.At times, diagnosis of psychiatric disease can be difficult in general practice, particularly if physical symptoms are also present. Antidepressants are the most common treatment modality for depression. Among them, selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) are commonly prescribed and have some side effects. Almost all antidepressants can cause sexual dysfunction and the prevalence of this side effect is over 90% [Harvey and Balon, 1995].Mitchell and Popkin believe that opinions vary regarding sexual dysfunction in men due to Study of effects of selective serotonin reuptake inhibitors on stages of sexual function in Iranian patients with major depressive disorder Mitra Safa, Saeid Sadr, Firouzeh Talischi and Fatemeh Ghasem Boroujerdi Abstract Objective: Depression is one of the most common psychiatric disorders in the world. Lifetime prevalence is 15% among men and 25% among women. Selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants and monoamine oxidase inhibitor antidepressants are often used for depression, with their own side effects. This study was carried out since little information on sexual dysfunction due to these medications is available in Iran. Methods: This observational cross-sectional study included 100 patients attending a university or private psychiatry clinic who, after an interview based on Diagnostic and Statistical Manual of Mental Disorders fourth edition criteria, were considered depressed. These patients had no history of depression, sexual dysfunction or use of psychiatric medications. Sexual functioning of patients was evaluated at the start of the study, and after 2, 4 and 8 weeks of treatment. Data were evaluated using SPSS software and t and χ 2 tests. Results: A total of 75% of patients reported sexual dysfunction: 66.7% of men and 79.7% of women. A total of 74.1% of patients on fluvoxamine, 100% on fluoxetine, 75% on sertraline, 71.4% on citalopram and 100% on paroxetine reported sexual dysfunction. The most frequent sexual dysfunction was difficulty with orgasm, which affected 41.17% of women and 33.33% of men. Conclusion:The incidence of sexual dysfunction among users of SSRIs was highest in patients on fluvoxamine, but this was not statistically significant. Minimization of sexual side effects should be an essential consideration when prescribing antidepressants.

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Trazodone for the Treatment of Sexual Dysfunction Induced by Serotonin Reuptake Inhibitors

Abstract: The 5-HT2 antagonist, trazodone, may be beneficial in the management of SSRI-induced sexual dysfunction. Large-scale, placebo-controlled, double-blind studies with 5-HT2 antagonists are required to substantiate these preliminary observations.

Cited by 47 publications

References 14 publications

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction

Organic Causes of Erectile Dysfunction in Men Under 40

Study of effects of selective serotonin reuptake inhibitors on stages of sexual function in Iranian patients with major depressive disorder

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