Trazodone - a new antidepressant

Al-Yassiri, M.M.; Ankier, S. I.; Bridges, P. K.

doi:10.1016/0024-3205(81)90586-5

Cited by 60 publications

(16 citation statements)

References 25 publications

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“…The explanation for the effects found with TZD are as yet unclear but may be postulated to include peripheral autonomic reflex changes as well as a central effect on vasomo tor tone. This is compatible with the known pharmacological profile of TZD [2,27],…”

Section: Discussionsupporting

confidence: 66%

A Double-Blind Non-Crossover Placebo-Controlled Study between Group Comparison of Trazodone and Amitriptyline on Cardiovascular Function in Major Depressive Disorder

Silverstone

Si³

et al. 1984

Psychopathology

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The cardiovascular effects of trazodone (TZD), amitriptyline (AMT) and placebo were studied in out-patients with major depression. AMT was shown to have the expected effects on the electrocardiograph and on systolic time intervals consistent with its proven anticholinergic and quinidine-like properties. TZD, in contrast, had no quinidine-like effects and minor effects on systolic time intervals. However, it was not without any cardiovascular effects. Although TZD was shown to be a safer preparation than the reference drug AMT, long-term monitoring is needed to explain the minor effect on heart rate and T wave changes.

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Section: Discussionsupporting

confidence: 66%

A Double-Blind Non-Crossover Placebo-Controlled Study between Group Comparison of Trazodone and Amitriptyline on Cardiovascular Function in Major Depressive Disorder

Silverstone

Si³

et al. 1984

Psychopathology

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“…Trazodone is a modem antidepressant drug, a triazolopyridine derivative, the pharmacology of which has been reviewed by Al-Yassiri et al (1981), and it has been reported to cause drowsiness (Kamiol et al, 1976;Brogden et al, 1981). Since the majority of depressed patients are anxious and have difficulty in sleeping, the present study set out to explore possible hypnotic effects of trazodone 150 mg nightly.…”

Section: Introduction Methodsmentioning

confidence: 99%

Trazodone enhances sleep in subjective quality but not in objective duration.

Montgomery¹,

Oswald²,

Morgan³

et al. 1983

Brit J Clinical Pharma

133

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1 Nine volunteer poor sleepers, of mean age 61 years, took trazodone 150 mg nightly for 3 weeks, preceded by 2 weeks and followed by 1 week of matching blanks, in order to examine the effects of electrophysiologically-recorded and subjectively-rated sleep. The second of the initial weeks of matching blanks served as a baseline week. 2 In the subjective ratings, sleep improved in quality on trazodone, significantly so in the first and second weeks of intake, though with significant rebound insomnia on the second withdrawal night. 3 Trazodone halved the frequency of arousals interrupting sleep, and it reduced the time spent in stage 1 (drowsiness). It increased the duration of slow-wave sleep (stages 3 + 4), with a negative rebound following withdrawal. It reduced the time spent in REM sleep, with a rebound above baseline levels after withdrawal. 4 Trazodone did not change total sleep duration, nor the time required to fall asleep. 5 The effects of trazodone were sustained or became enhanced during the period of intake. They persisted for over 24 h after the last dose, and rebound effects were maximal on the second withdrawal night.

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“…Trazodone is an antidepressant agent with a chemical structure unrelated to existing psychomotor drugs (Al-Yassiri et al, 1981;Brogden et al, 1981;Ayd & Settle, 1982;Georgotas et al, 1982;Rawls, 1982) which is sedative and impairs critical flicker fusion threshold in young and elderly volunteers (Bayer et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

Warrington¹,

Ankier²,

Turner³

1984

Brit J Clinical Pharma

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The pharmacodynamic effects of single doses of trazodone (100 mg), amitriptyline (50 mg) or placebo either alone or with ethanol (0.5 ml/kg) were investigated in six healthy volunteers in a double‐blind crossover study. Plasma concentrations of the drugs and ethanol were also measured. Pharmacodynamic tests were critical flicker fusion frequency threshold (CFF), choice reaction time (CRT), manual dexterity, a digit span test and visual analogue scales. Blood ethanol concentrations were not influenced by the co‐administration of either antidepressant. tmax for trazodone was prolonged by ethanol but the other pharmacokinetic parameters for trazodone and amitriptyline were not influenced by ethanol. Trazodone and amitriptyline caused the expected profound depressant effects on CFF, CRT, manual dexterity and on the rating scales for drowsiness, ‘clear‐headedness’, aggression and disinhibition. Ethanol alone impaired manual dexterity, increased drowsiness, reduced ‘clear headedness’ and also tended to reduce feelings of aggression. In combination with either trazodone or amitriptyline, ethanol caused little additional effect except in the case of manual dexterity which was further impaired. This result may reflect the profound effects of the antidepressants alone and does not suggest that it is safe for patients receiving antidepressant medication to take ethanolic drinks.

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Trazodone - a new antidepressant

Cited by 60 publications

References 25 publications

A Double-Blind Non-Crossover Placebo-Controlled Study between Group Comparison of Trazodone and Amitriptyline on Cardiovascular Function in Major Depressive Disorder

A Double-Blind Non-Crossover Placebo-Controlled Study between Group Comparison of Trazodone and Amitriptyline on Cardiovascular Function in Major Depressive Disorder

Trazodone enhances sleep in subjective quality but not in objective duration.

An evaluation of possible interactions between ethanol and trazodone or amitriptyline.

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