Traxoprodil decreases pentylenetetrazol-induced seizures

Blockade of GluN2B-containing NMDA receptors reduces short-term brain damage induced by early-life status epilepticus

“…containing NMDAR with CP-101,606 or CI-1041 did not stop SE-induced seizures. This was a surprising result since others previously reported anticonvulsant activity of these antagonists in higher, similar or even lower dosage than the used here (Barton and White, 2004;Brackett et al, 2000;Naspolini et al, 2012;Vartanian et al, 2000). One can argue that GluN2B-containing NMDAR antagonism present different anticonvulsant actions in adult and developmental brain.…”

“…(For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) antagonists was already reported in both adult and immature rats (Mares and Mikulecka, 2009;Naspolini et al, 2012;Szczurowska and Mares, 2015). We believe that the most plausible explanation for these contrasting results is the different models used to induce seizures.…”

Aggravation of Seizure‐like Events by Hydrogen Sulfide: Involvement of Multiple Targets that Control Neuronal Excitability

“…The effect of H 2 S on SLEs was prevented by the blockers of voltage‐gated sodium channel, AMPAR, and NMDAR, indicating that some AEDs, including felbamate, topiramate, or zonisamide, exert their effects by blocking of Na + channel , AMPAR antagonists such as perampanel , and NMDAR antagonists such as traxoprodil which could also be used in the treatment with H 2 S‐aggregated SLEs.…”

Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation

“…While spermidine produces a different profile of CNS excitation following icv administration compared to spermine, Naspolini and co-workers demonstrated potentiation of seizures in rats given spermidine and sub-threshold concentrations of pentylenetetrazol. This effect was reversed by the NR2B subunit selective antagonist traxoprodil (Naspolini et al, 2012).…”