Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice

Stasiuk, Weronika; Serefko, Anna; Szopa, Aleksandra; Wyska, Elżbieta; Świąder, Katarzyna; Właź, Piotr; Poleszak, Ewa

doi:10.1016/j.pharep.2016.04.013

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…Auto-Track (Columbus Instruments, OH, USA), as was described in details previously [52]. The animals were placed individually in an actometer for 30 min.…”

Section: Spontaneous Locomotor Activitymentioning

confidence: 99%

New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation

Fiorino

Magli

Kędzierska

et al. 2017

Bioorganic & Medicinal Chemistry

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“…Auto-Track (Columbus Instruments, OH, USA), as was described in details previously [52]. The animals were placed individually in an actometer for 30 min.…”

Section: Spontaneous Locomotor Activitymentioning

confidence: 99%

New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation

Fiorino

Magli

Kędzierska

et al. 2017

Bioorganic & Medicinal Chemistry

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“…It has been shown that NMDA receptor ligands potentiate the effects of conventionally used antidepressant medications (Cieślik et al 2007 ; Poleszak et al 2011 ; 2013 , 2016 ; Siwek et al 2009 ; Stasiuk et al 2016 ; Wlaź et al 2011 ). The present study is a follow-up to our previous research in which the effect of traxoprodil on the activity of commonly used antidepressants (Poleszak et al 2016 ), and drugs with atypical mechanism of action, i.e., mianserin, tianeptine and agomelatine (Stasiuk et al 2016 ) were assessed. Therefore, the main goal of this study was to assess the effect of traxoprodil, at the inactive dose, on the activity of antidepressant drugs acting through diverse mechanisms, i.e., desipramine—the tricyclic antidepressant (TCA), paroxetine—a selective serotonin reuptake inhibitor (SSRI), milnacipran selective serotonin and norepinephrine reuptake inhibitor (SNRI), and bupropion—a norepinephrine–dopamine reuptake inhibitor (NDRI) in forced swim test (FST) in mice.…”

Section: Introductionmentioning

confidence: 99%

Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice

et al. 2016

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Pre-clinical and clinical studies indicated that a blockade of the NMDA receptor complex creates new opportunities for the treatment of affective disorders, including depression. The aim of the present study was to assess the influence of traxoprodil (10 mg/kg) on the activity of desipramine (10 mg/kg), paroxetine (0.5 mg/kg), milnacipran (1.25 mg/kg), and bupropion (10 mg/kg), each at sub-therapeutic doses. Moreover, brain levels of traxoprodil and tested agents were determined using HPLC. The obtained results were used to ascertain the nature of occurring interaction between traxoprodil and studied antidepressants. The experiment was carried out on naïve adult male Albino Swiss mice. Traxoprodil and other tested drugs were administered intraperitoneally. The influence of traxoprodil on the activity of selected antidepressants was evaluated in forced swim test (FST). Locomotor activity was estimated to exclude false positive/negative data. To assess the influence of traxoprodil on the concentration of used antidepressants, their levels were determined in murine brains using HPLC. Results indicated that traxoprodil potentiated activity of all antidepressants examined in FST and the observed effects were not due to the increase in locomotor activity. Only in the case of co-administration of traxoprodil and bupropion, increased bupropion concentrations in brain tissue were observed. All tested agents increased the traxoprodil levels in the brain. Administration of a sub-active dose of traxoprodil with antidepressants from different chemical groups, which act via enhancing monoaminergic transduction, caused the antidepressant-like effect in FST in mice. The interactions of traxoprodil with desipramine, paroxetine, milnacipran, and bupropion occur, at least partially, in the pharmacokinetic phase.

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New‐generation, non‐SSRI antidepressants: Drug‐drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

Protti

Mandrioli

Marasca

et al. 2020

Medicinal Research Reviews

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After the development of “classical” tricyclic antidepressants and monoamine oxidase inhibitors, numerous other classes of antidepressant drugs have been introduced onto the market. The selective serotonin reuptake inhibitor class is the best‐known one, but many others exist, usually identified by their mechanism of activity. In this second part of the review, focused on new‐generation antidepressants not included among selective serotonin reuptake inhibitors, the following classes are considered: noradrenergic and selective serotonergic antidepressants; norepinephrine reuptake inhibitors; serotonin, norepinephrine and dopamine reuptake inhibitors; melatonergic agonists and selective serotonergic antagonists; norepinephrine and dopamine reuptake inhibitors; and so forth. These different mechanisms underlie tolerability and safety profiles that can be very different among the classes, with each one providing significant advantages and disadvantages in comparison with others. The main characteristics of the following antidepressants are described: mianserin, mirtazapine, setiptiline, reboxetine, viloxazine, teniloxazine, atomoxetine, nefazodone, agomelatine, bupropion, esketamine, and tianeptine. The paper is focused on their metabolism and interactions, but also includes brief notes on analytical methods useful for their therapeutic drug monitoring.

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Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice

Abstract: Traxoprodil-agomelatine interaction is pharmacokinetic in nature. A combination of these agents has a potential to become an interesting strategy in the treatment of depression.

Cited by 6 publications

References 18 publications

New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation

New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation

Influence of the selective antagonist of the NR2B subunit of the NMDA receptor, traxoprodil, on the antidepressant-like activity of desipramine, paroxetine, milnacipran, and bupropion in mice

New‐generation, non‐SSRI antidepressants: Drug‐drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others

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