Travma Sonrası Stres Bozukluğunda HPA Ekseninin Disregülasyonu

Abstract

Many endocrinological studies have evaluated the role of the hypothalamic-pituitary-adrenal axis in the pathophysiology of post-traumatic stress disorder and have created models. There are many reasons for looking for biomarkers, especially in monitoring treatment effectiveness, and the fact that trauma victims differ in terms of comorbidity, clinical appearance, trauma etiology, and time after trauma lead to variatons in findings. In this review, methods and findings of studies investigating the effects on hypothalamic-pituitary-adrenal function in post-traumatic stress disorder and the findings about hypothalamic-pituitary-adrenal axis hormones tested as biological therapy markers have been discussed.