Traversing Phase Fields towards Nanosized Beta Tricalcium Phosphate

Gross, Kārlis Agris; Andersons, Juris; Misevicius, Martynas; Svirksts, Janis

doi:10.4028/www.scientific.net/kem.587.97

Cited by 8 publications

(7 citation statements)

References 2 publications

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“…The structural characterization of the CPPs used a combination of XRD, FTIR, and 31 P MAS NMR techniques. The XRD pattern of the as-prepared CPPs (Figure A) shows three broad reflections observed between 20 and 60 degrees 2θ, which indicates the amorphous nature of these particles as reported in the literature. − Figure B shows that the nature of bonding in the CPPs can be determined by FTIR. All bands are assigned according to previous literature reports. ,− Specifically, the bands measured at 540, 730, 790, and 900 cm –1 are all assigned to vibrational and stretching modes of the P–O–P bonding.…”

Section: Resultssupporting

confidence: 62%

Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation

Bradley

Zhou

et al. 2021

ACS Appl. Nano Mater.

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Phosphate-based glasses are well-studied biodegradable materials in the bulk. However, less is known about the synthesis and properties of phosphate glass when prepared as microparticles or nanoparticles. These glasses have excellent biodegradability and biocompatibility. Therefore, phosphate glass micro/nanoparticles have significant potential for advances in drug delivery, bioimaging, degradable implants, and tissue engineering. In this study, calcium phosphate micro/nanoparticles (CPPs) with the composition (P 2 O 5 ) 25 -(CaO) 75 were prepared through a combination of the sol−gel and electrospray methods. This synthesis method shows great flexibility in controlling the size and morphology of CPPs. CPPs with an average diameter in the range of 345−952 nm and various morphologies including carnation flower-like, golf-ball-like, and apple-like were obtained. Optical microscopy was further used to demonstrate that the CPPs can have an average size increase of 95% in diameter and 720% in volume within the first 5−10 min of hydration in neutral aqueous media. The hydro-expansion process is accompanied by a two-stage ion release of phosphorus and calcium. We propose to utilize the expansion of the particle to mechanically ablate tissue and destroy cells.

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Section: Resultssupporting

confidence: 62%

Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation

Bradley

Zhou

et al. 2021

ACS Appl. Nano Mater.

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“…The broad peaks in the XRD patterns of the as‐prepared microspheres may indicate that the material was poorly crystallized, or consisted of nanometer‐sized crystals, or a combination of both. These patterns are typical for CDHA 36,37 . The intensity of the peaks increased markedly for the heat‐treated microspheres, presumably as the result of increased crystal fraction or crystal size.…”

Section: Resultsmentioning

confidence: 75%

“…These patterns are typical for CDHA. 36,37 The intensity of the peaks increased markedly for the heat-treated microspheres, presumably as the result of increased crystal fraction or crystal size. The XRD patterns of heat-treated microspheres indicate the presence of various weight ratios of HA and β-TCP.…”

Section: Micro-and Mesostructures Of As-prepared and Heat-treated Hol...mentioning

confidence: 98%

Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

2022

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Hollow biphasic calcium phosphate (BCP) microspheres with different fractions of nanocrystalline hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) were prepared, and their in vitro and in vivo reactivity were assessed. The microspheres were prepared by reacting soluble borate glass microspheres in phosphate solutions (0.1-or 0.25-M K 2 HPO 4 ) with different values of pH (7-12) to produce hollow calcium-deficient hydroxyapatite (CDHA) microspheres with Ca/P ratios that increased with solution pH. Heating the hollow CDHA microspheres to 800 • C produced hollow, nanoporous BCP microspheres with ratios of nanocrystalline HA and β-TCP that correspond to the Ca/P ratio of the CDHA precursors. Hollow BCP microspheres with a greater fraction of β-TCP released calcium ions most quickly in a K-acetate acidic buffer solution, consistent with their greater bioactivity in the in vivo tests. CDHA and BCP microspheres converted to nanocrystalline carbonated HA when immersed in 37 • C simulated body fluid. Hollow CDHA and BCP microspheres were implanted in rat calvarial defects, and after 8 weeks, the BCP microspheres with a β-TCP/HA ratio of 70/30 (by weight) promoted a greater fraction of new bone formation (33% ± 7%) compared to BCP microspheres with a β-TCP/HA ratio of 44/56 (20% ± 9%) and compared to the respective CDHA precursor microspheres (17% ± 4%, 17% ± 5%). Bone formation was not observed in the subcutaneous implants of any types of these hollow microspheres, after 8 and 12 weeks, and the more reactive BCP microspheres (β-TCP/HA = 70/30) were associated with significantly more blood vessel formation in the subcutaneous implants. These results indicate that the properties of hollow BCP microspheres can be tailored by their processing conditions and are useful as scaffold materials for tissue regeneration.

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“…Sirirat et al (2013) reported that addition of nano -chromium picolinate to laying hens diets at levels of 500 or 3000ppb had no significant effect on Ca retention. Gross et al (2014) reported that calcium phosphate materials in nano-size have higher specific surface area and surface roughness compared to conventional calcium phosphate materials. Therefore, nano-sized calcium phosphate materials have stronger interaction with organic materials.…”

Section: Table (2): Effect Of Dietary Nano Di-calcium Phosphate (Ndcpmentioning

confidence: 99%

Effect of Nano Dicalcium Phosphate Supplemetation on Eggshell Structure and Calcium and Phosphorus Utilization

El-Sheikh

Abou-Elnaga

2018

Egyptian Journal of Nutrition and Feeds

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his study was conducted to evaluate the efficiency of dietary varying levels of nano di-calcium phosphate (NDCP) on eggshell quality [total thickness (EST), mammillary layer thickness (MT), and mammillary density (MD)] egg mineral contents, bone breaking strength, serum calcium and phosphorus concentrations and calcium (Ca) and phosphorus (P) retention in old laying hen. Therefore, one hundred and eighty brown LSL hens at the age of 52 weeks of age were used for 12 weeks at the end of their production period. Hens were divided into four equal groups, 45 birds/group with nine replicates each. The treatments were as follows: Group (1): basal diet (control); Group (2): basal diet + 200g NDCP/ ton; Group (3): basal diet + 400g NDCP/ ton; and Group (4): basal diet + 800g NDCP/ ton. Results detected that serum Ca and P concentration, tibia fresh weight, tibia ash, tibia Ca, Ca and P retention were significantly increased stuck with the increase in NDCP supplementation level up to 400 g / ton and tend to decrease after that. Furthermore, Yolk mineral content (Ca and p) accumulation was significantly decreased with increasing NDCP levels. There were no significant differences in tibia breaking strength and tibia P with the supplementation in comparison with the control group. Eggshell thickness and breaking strength increased parallel to the increase in NDCP levels due to the increase in palisade layer and mammillary layer. In conclusion supplementation of NDCP up to 400 g/ ton to layers diet may be help in solving the problems of egg shell weakness at the end of egg laying season or old hen production.

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Traversing Phase Fields towards Nanosized Beta Tricalcium Phosphate

Cited by 8 publications

References 2 publications

Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation

Hydro-Expandable Calcium Phosphate Micro/Nano-Particles with Controllable Size and Morphology for Mechanical Ablation

Conversion of borate glass microspheres to hollow biphasic calcium phosphate ceramic microspheres for bone defects

Effect of Nano Dicalcium Phosphate Supplemetation on Eggshell Structure and Calcium and Phosphorus Utilization

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