Travelling with heart failure: risk assessment and practical recommendations

Haehling, Stephan von; Birner, Christoph; Dworatzek, Elke; Frantz, Stefan; Hellenkamp, Kristian; Israel, Carsten W.; Kempf, Tibor; Klein, Hermann H.; Knosalla, Christoph; Laufs, Ulrich; Raake, Philip; Wachter, Rolf; Hasenfuß, Gerd

doi:10.1038/s41569-021-00643-z

Cited by 13 publications

(8 citation statements)

References 81 publications

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“…(b) Hipoksia hipobarik yang diinduksi ketinggian menyebabkan peningkatan laju pernapasan dan volume. 12 Gagal Jantung Pasien gagal jantung lebih rentan terhadap perubahan fisiologis yang disebabkan oleh perubahan ketinggian dibandingkan populasi umum. Perjalanan ke lokasi dengan ketinggian >2.500 m di atas permukaan laut akan memicu proses aklimatisasi fisiologis sistem kardiosirkulasi dan paru.…”

Section: Pendahuluanunclassified

“…Untuk mengkompensasi kadar oksigen arteri yang lebih rendah, denyut jantung dan volume sekuncup meningkat melalui aktivasi sistem saraf simpatik. 12 Suplementasi oksigen umumnya direkomendasikan untuk penumpang dengan New York Heart Association (NYHA) kelas III/IV penumpang dengan saturasi oksigen arteri <92%. 2 Penumpang dengan NYHA kelas IV dengan gejala gagal jantung disarankan untuk tidak terbang tanpa pertimbangan khusus dan ketersediaan oksigen dalam penerbangan.…”

Section: Pendahuluanunclassified

“…Pasien yang terpasang LVAD atas indikasi tersebut, diperbolehkan melakukan perjalanan udara jika pasien stabil secara medis dan telah menjalani rehabilitasi yang adekuat. 12 Tromboemboli Vena Terdapat tiga faktor yang berkontribusi terhadap risiko trombosis vena menurut trias Virchow, yaitu stasis vena, hiperkoagulabilitas, dan kerusakan endotel. 17,18 Penurunan tekanan udara, terlepasnya nitrat oksida, serta imobilitas akan dapat meningkatkan risiko VTE, terutama jika indeks massa tubuh lebih dari 30 kg/m 2 .…”

Section: Kondisi Medis Rekomendasiunclassified

“…19,20 Riwayat Operasi Jantung Canadian Cardiac Society merekomendasikan bahwa pasien dengan kadar hemoglobin <9 g/dL yang baru menjalani operasi bedah pintas koroner (CABG) disarankan menghindari perjalanan udara selama 3-10 hari pasca-operasi sampai udara di dalam rongga dada terserap sempurna, karena gas mengembang saat tekanan udara menurun berbanding terbalik dengan peningkatan ketinggian (hukum Boyle). 12…”

Section: Kondisi Medis Rekomendasiunclassified

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Perjalanan Udara pada Penderita Penyakit Jantung: Amankah?

Koswara¹,

Yap

Chandra

et al. 2023

Cermin Dunia Kedokteran

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Perubahan tekanan, suhu, tingkat kelembapan, keadaan imobilisasi, suara bising, turbulensi, dan ekspansi udara di rongga tubuh yang berkaitan dengan perjalanan via udara dapat berdampak pada tubuh manusia. Para penumpang dengan riwayat penyakit jantung harus menyadari risikonya dan melakukan tindakan pencegahan. Changes in pressure, temperature, humidity levels, immobilization, noise, turbulence, and expansion of air in the body cavity associated with air travel can all have an impact on the human body. Passengers with a history of heart disease must be aware of the risks and take the necessary precautions.

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Section: Pendahuluanunclassified

Section: Kondisi Medis Rekomendasiunclassified

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Perjalanan Udara pada Penderita Penyakit Jantung: Amankah?

Koswara¹,

Yap

Chandra

et al. 2023

Cermin Dunia Kedokteran

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“…

Cardiac remodelling, driven by inflammatory responses, neurohormones and reactive oxygen species (ROS) accumulation, exacerbates cardiac fibrosis and enlargement. 1,2 Due to the abnormal function and structure of the heart, the ventricular ejection function is reduced, which in turn causes organ congestion and ischemia. 3,4 Currently, epidemiological studies show that the incidence of heart failure in adults is approximately 2%.

…”

mentioning

confidence: 99%

Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation

Zhang

Shaohuan

Tang

et al. 2023

J Cellular Molecular Medi

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Resveratrol is an organic compound widely studied for its therapeutic uses. We investigated whether resveratrol exerts cardioprotective effects by inhibiting ferroptosis via the Sirt1/p53 pathway. A heart failure model was established by aortic coarctation in Sirt1 knockout mice. The superoxide dismutase (SOD), glutathione (GSH) levels and mitochondrial morphology in murine heart tissues were assessed at different time points to determine the role of ferroptosis in heart failure progression. The cardiac function of mice with heart failure was evaluated by determining the brain natriuretic peptide (BNP) and sST2 concentration and conducting echocardiography. Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) were transfected with the p53 K382R mutant and Sirt1 interference lentiviral vectors. Immunoprecipitation (IP) experiments were performed to investigate whether Sirt1 influences ferroptosis via p53 K382 acetylation and SLC7A11 expression modulation. Resveratrol improved cardiac function in mice and decelerated ferroptosis and fibrosis progression in heart failure. However, the ability of resveratrol to prevent ferroptosis and treat heart failure was lost after silencing Sirt1. Sirt1 reduced ferroptosis by diminishing the levels of p53 K382 acetylation, reducing the degradation of SLC7A11, and increasing the levels of GSH and glutathione peroxidase 4 (GPX4) in cells. In conclusion, by activating the Sirt1/p53 pathway in heart failure, resveratrol decreased the depletion of SLC7A11, inhibited ferroptosis, and improved cardiac function.

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In-Flight Evaluation and Management of Cardiac Illness

Duchâteau¹,

Ramin²

2023

In-Flight Medical Emergencies

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Travelling with heart failure: risk assessment and practical recommendations

Cited by 13 publications

References 81 publications

Perjalanan Udara pada Penderita Penyakit Jantung: Amankah?

Perjalanan Udara pada Penderita Penyakit Jantung: Amankah?

Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation

In-Flight Evaluation and Management of Cardiac Illness

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