Travellers’ risk behaviors and health problems: Post-travel follow up in two travel medicine centers in Italy

Stefanati, Armando; Pierobon, Anna; Baccello, Valeria; DeStefani, E.; Gamberoni, Diego; Furlan, Patrizia; Sandri, Federica; Stano, Ann Stephanie; Coin, P G; Baldo, Vincenzo; Gabutti, Giovanni

doi:10.1016/j.medmal.2020.10.009

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…To the best of our knowledge, here, we report on the first Italian study regarding TBE vaccine acceptance in people who may potentially be exposed to tick bites, not only within the domain of travel medicine but also among the general population living in high-risk areas [49][50][51], and our results appear to be substantially in line with previous international reports [52,53]. For instance, a recent survey from 20 European countries provided a pooled vaccination rate of 22% (range: 7% in Romania to 81% in Austria) [18,24], while a cross-sectional study from 11 European countries (year: 2018; Czech Republic, Estonia, Finland, Germany, Hungary, Latvia, Lithuania, Poland, Slovakia, Slovenia, and Sweden) identified an average vaccination rate of 25% [24,28].…”

Section: Discussionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

Riccò,

Corrado,

Marchesi

et al. 2023

TropicalMed

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Tick-borne encephalitis (TBE) represents a potential health threat for tourists in high-risk areas, including the Dolomite Mountains in northeastern Italy. The present questionnaire-based survey was, therefore, designed in order to assess knowledge, attitudes, and preventive practices (KAP) in a convenience sample of Italian tourists visiting the Dolomite Mountains, who were recruited through online discussion groups. A total of 942 participants (39.2% males, with 60.2% aged under 50) filled in the anonymous survey from 28 March 2023 to 20 June 2023. Overall, 24.1% of participants were vaccinated against TBE; 13.8% claimed to have previously had tick bites, but no cases of TBE were reported. The general understanding of TBE was relatively low; while 79.9% of participants acknowledged TBE as a potentially severe disease, its occurrence was acknowledged as high/rather high or very high in the Dolomites area by only 51.6% of respondents. Factors associated with the TBE vaccine were assessed by the calculation of adjusted odds ratios (aOR) and 95% confidence intervals through a logistic regression analysis model. Living in areas considered at high risk for TBE (aOR 3.010, 95%CI 2.062–4.394), better knowledge on tick-borne disorders (aOR 1.515, 95%CI 1.071–2.142), high risk perception regarding tick-borne infections (aOR 2.566, 95%CI 1.806–3.646), a favorable attitude toward vaccinations (aOR 3.824, 95%CI 1.774–8.224), and a tick bite(s) in a previous season (aOR 5.479, 95%CI 3.582–8.382) were characterized as being positively associated with TBE vaccination uptake. Conversely, being <50 years old (aOR 0.646, 95%CI, 0.458–0.913) and with a higher risk perception regarding the TBE vaccine (aOR 0.541, 95%CI 0.379–0.772) were identified as the main barriers to vaccination. In summary, tourists to the high-risk area of the Dolomites largely underestimate the potential occurrence of TBE. Even though the uptake of the TBE vaccine in this research was in line with European data, public health communication on TBE is required in order to improve acceptance of this effective preventive option.

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Section: Discussionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

Riccò,

Corrado,

Marchesi

et al. 2023

TropicalMed

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“…One highly prevalent and particularly fascinating diarrheal agent is the heat-stable Escherichia coli enterotoxin STa, the most frequent causal agent for travelers' diarrhea, an extremely frequent event during international travel. 4 This enterotoxin binds to and activates the receptor kinase guanylate cyclase C (Gucy2c) in the enterocyte brush border membrane, thus mimicking the downstream effects of the endogenous guanylins. 5 Gucy2c knockout mice are resistant to the diarrheal effects of STa, 6,7 and pharmacological Gucy2c inhibitors also reduce STa-induced chloride channel activation, 8 suggesting that this strategy may be successful in the treatment of acute enterotoxic E. coli-induced diarrhea, as well as in treating the rare congenital secretory diarrhea caused by activating Gucy2c mutations.…”

Section: Introductionmentioning

confidence: 99%

“…One highly prevalent and particularly fascinating diarrheal agent is the heat‐stable Escherichia coli enterotoxin STa, the most frequent causal agent for travelers' diarrhea, an extremely frequent event during international travel 4 . This enterotoxin binds to and activates the receptor kinase guanylate cyclase C (Gucy2c) in the enterocyte brush border membrane, thus mimicking the downstream effects of the endogenous guanylins 5 .…”

Section: Introductionmentioning

confidence: 99%

cGMP‐dependent kinase 2, Na⁺/H⁺ exchanger NHE3, and PDZ‐adaptor NHERF2 co‐assemble in apical membrane microdomains

Luo,

Liu,

Nikolovska

et al. 2024

Acta Physiologica

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AimTrafficking, membrane retention, and signal‐specific regulation of the Na+/H+ exchanger 3 (NHE3) are modulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ‐adapter proteins. This study explored the assembly of NHE3 and NHERF2 with the cGMP‐dependent kinase II (cGKII) within detergent‐resistant membrane microdomains (DRMs, “lipid rafts”) during in vivo guanylate cycle C receptor (Gucy2c) activation in murine small intestine.MethodsSmall intestinal brush border membranes (siBBMs) were isolated from wild type, NHE3‐deficient, cGMP‐kinase II‐deficient, and NHERF2‐deficient mice, after oral application of the heat‐stable Escherichia coli toxin (STa) analog linaclotide. Lipid raft and non‐raft fractions were separated by Optiprep density gradient centrifugation of Triton X‐solubilized siBBMs. Confocal microscopy was performed to study NHE3 redistribution after linaclotide application in vivo.ResultsIn the WT siBBM, NHE3, NHERF2, and cGKII were strongly raft associated. The raft association of NHE3, but not of cGKII, was NHERF2 dependent. After linaclotide application to WT mice, lipid raft association of NHE3 decreased, that of cGKII increased, while that of NHERF2 did not change. NHE3 expression in the BBM shifted from a microvillar to a terminal web region. The linaclotide‐induced decrease in NHE3 raft association and in microvillar abundance was abolished in cGKII‐deficient mice, and strongly reduced in NHERF2‐deficient mice.ConclusionNHE3, cGKII, and NHERF2 form a lipid raft‐associated signal complex in the siBBM, which mediates the inhibition of salt and water absorption by Gucy2c activation. NHERF2 enhances the raft association of NHE3, which is essential for its close interaction with the exclusively raft‐associated activated cGKII.

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“…These situations can be costly for the traveler, as not all costs are always covered by insurance [1,2]. Incidences of reported health problems in travelers vary between 40% and 80% in previous studies [3][4][5][6]. Siikamaki et al reported that Finnish travelers were more frequently hospitalized for infections (49%), than for injuries (18%) or vascular diseases (9%) [6].…”

Section: Introductionmentioning

confidence: 99%

Hospital-Based Care And/Or Death Followed by Repatriation in Dutch Travelers: The HAZARD Study

Vlot

Steenbergen²,

Luppino³

et al. 2022

SSRN Journal

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Travellers’ risk behaviors and health problems: Post-travel follow up in two travel medicine centers in Italy

Cited by 8 publications

References 20 publications

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

cGMP‐dependent kinase 2, Na⁺/H⁺ exchanger NHE3, and PDZ‐adaptor NHERF2 co‐assemble in apical membrane microdomains

Hospital-Based Care And/Or Death Followed by Repatriation in Dutch Travelers: The HAZARD Study

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Travellers’ risk behaviors and health problems: Post-travel follow up in two travel medicine centers in Italy

Cited by 8 publications

References 20 publications

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

Tick-Borne Encephalitis Virus Vaccination among Tourists in a High-Prevalence Area (Italy, 2023): A Cross-Sectional Study

cGMP‐dependent kinase 2, Na+/H+ exchanger NHE3, and PDZ‐adaptor NHERF2 co‐assemble in apical membrane microdomains

Hospital-Based Care And/Or Death Followed by Repatriation in Dutch Travelers: The HAZARD Study

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Product

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cGMP‐dependent kinase 2, Na⁺/H⁺ exchanger NHE3, and PDZ‐adaptor NHERF2 co‐assemble in apical membrane microdomains