Abstract:Recently we have revealed a minimal reaction subnetwork in the MAPK (mitogen‐activated protein kinase) cascade that is responsible for the emergence of bistable and oscillatory behavior. Here we examine a possible mechanism that provides for the propagation of increased MAPK activity in cell populations by interconnecting the intracellular MAPK subnetwork with the ligand‐receptor signaling machinery. Such approach allows for significant reduction of the dimensionality of the parameter space on one hand and the… Show more
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