Abstract:With the rapid development of e-commerce and the global economy, order picking mode of multiple batches and small quantities becoming more and more, which makes artificial picking system occupy a larger proportion in a variety of ways. The optimization study of the artificial person picking system has a crucial role to enhance the efficiency of batch picking, then increasing customer satisfaction. For picking route optimization problem, single or multiple picking equipment may be considered in the actual operation process in order to choose the shortest path as the objective function to establish the optimization model in this paper. And genetic algorithm is designed in detail to solve this model.