Traumatic Spinal Cord Injury

Lazaridis, C.; Andrews, Charles

doi:10.1097/ccm.0000000000000077

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…Traumatic damage to the spinal cord triggers a progressive cascade of pathophysiological events that finally result in a cystic cavity filled of fluid . Infiltration of cellular elements and regeneration of axons are severely hindered due to the lack of extracellular matrix (ECM) in the cavity, which thus becomes a major obstacle for neural regeneration following spinal cord injury (SCI) .…”

Section: Introductionmentioning

confidence: 99%

“…Traumatic damage to the spinal cord triggers a progressive cascade of pathophysiological events that finally result in a cystic cavity filled of fluid. 1 Infiltration of cellular elements and regeneration of axons are severely hindered due to the lack of extracellular matrix (ECM) in the cavity, which thus becomes a major obstacle for neural regeneration following spinal cord injury (SCI). 2 As a feasible solution, biomaterial scaffolds have attracted considerable attention by serving as artificial ECM to bridge the cavity, potentially fostering the anatomical structure and function of damaged axons.…”

Section: ■ Introductionmentioning

confidence: 99%

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Engineering Microenvironment for Endogenous Neural Regeneration after Spinal Cord Injury by Reassembling Extracellular Matrix

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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The formation of a fluid-filled cystic cavity after spinal cord injury (SCI) is a major obstacle for neural regeneration. In this study, the post-SCI cavity was bridged by a functional self-assembling peptide (F-SAP) nanofiber hydrogel coupled with growth factor “cocktail”. A sustained release of growth factors was achieved by carefully tailoring the physical hindrances and charge-induced interactions between the growth factors and the peptide nanofibers. Such an engineering microenvironment elicited axon regeneration, as determined by tracing of the descending pathway in the dorsal columns and immunochemical detection of regenerating axons beyond the lesion. Furthermore, the dynamic spatiotemporal activation line of endogenous NSCs (eNSCs) after severe SCI was thoroughly investigated. The results indicated that the growth factor-coupled F-SAP greatly facilitated eNSC proliferation, neuronal differentiation, maturation, myelination, and more importantly, the formation of interconnection with severed descending corticospinal tracts. The robust endogenous neurogenesis essentially led to the recovery of locomotion and electrophysiological properties. In conclusion, the growth factor-coupled F-SAP nanofiber hydrogel elucidated the therapeutic effect of eliciting endogenous neurogenesis by locally reassembling an extracellular matrix.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Engineering Microenvironment for Endogenous Neural Regeneration after Spinal Cord Injury by Reassembling Extracellular Matrix

Liu

et al. 2020

ACS Appl. Mater. Interfaces

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“…lncRNAs have been proved as essential mediators in the development of SCI. After SCI, countless cytokines and signaling pathways have been demonstrated to mediate the apoptosis and inflammatory response [ 14 , 15 ]. LPS-stimulated microglial cells are widely utilized to explore the pathogenesis of SCI.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p

Zhong

Bao

et al. 2021

Open Medicine

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Long noncoding RNAs have been demonstrated to play crucial roles in the pathogenesis of spinal cord injury (SCI). In this study, we aimed to explore the roles and underlying mechanisms of lncRNA X-inactive specific transcript (XIST) in SCI progression. SCI mice model was constructed and evaluated by the Basso–Beattie–Bresnahan method. The SCI cell model was constructed by treating BV2 cells with lipopolysaccharide (LPS). The levels of XIST and miR-219-5p were determined by the reverse transcription quantitative polymerase chain reaction. The concentrations of inflammatory cytokines were measured by enzyme-linked immunosorbent assay. Protein levels were measured via western blot assay. Cell viability and apoptosis were evaluated by cell counting kit-8 assay and flow cytometry analysis, respectively. The relationship between XIST and miR-219-5p was analyzed by online tool starBase, dual-luciferase reporter assay, and RNA immunoprecipitation assay. As a result, the XIST level was enhanced and the miR-219-5p level was declined in the SCI mice model. XIST was also upregulated in LPS-induced BV2 cells. LPS treatment restrained BV2 cell viability and accelerated apoptosis and inflammatory response. XIST knockdown effectively weakened LPS-induced BV2 cell injury. miR-219-5p was identified as a target of XIST. Moreover, inhibition of miR-219-5p restored the impacts of XIST knockdown on cell viability, apoptosis, and inflammation in LPS-treated BV2 cells. In addition, LPS-induced XIST promoted the activation of the nuclear factor-κB (NF-κB) pathway by sponging miR-219-5p. In conclusion, XIST silencing promoted microglial cell viability and repressed apoptosis and inflammation by sponging miR-219-5p, thus promoting the recovery of SCI.

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“…These articles consisted 34 original research articles, 6,8,9,21e51 13 conference abstracts, 52e63 13 literature reviews, 24,64e75 4 systematic reviews, 5,13e15 4 letters to the editor, 76e79 3 perspective articles, 80e82 and 2 editorials. 83,84 One article was published in 1979 and all other between 2008 and 2022. Specifically, articles were published in 2008 (n ¼ 1), 2009…”

Section: Article Characteristicsmentioning

confidence: 99%

Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review

Gee¹

2022

Journal of Clinical Orthopaedics and Trauma

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Traumatic Spinal Cord Injury

Cited by 7 publications

References 14 publications

Engineering Microenvironment for Endogenous Neural Regeneration after Spinal Cord Injury by Reassembling Extracellular Matrix

Engineering Microenvironment for Endogenous Neural Regeneration after Spinal Cord Injury by Reassembling Extracellular Matrix

Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p

Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review

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