Traumatic spinal cord injury

Atrice, Myrtice B.; Morrison, Sarah; McDowell, Shari; Ackerman, Paula M.; Foy, Teresa; Tefertiller, Candy

doi:10.1016/b978-0-323-07586-2.00025-x

Cited by 6 publications

(4 citation statements)

References 157 publications

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“…Conventional gait rehabilitation following stroke usually is designed to emphasize facilitation of recovery through strengthening and endurance training of the unaffected muscles and compensation for nonremediable deficits by using braces and assistive devices for support (Somers, 1992;Atrice et al, 1995). Together, these therapeutic strategies are designed to promote maximum functional capacity of muscles and to compensate for the absence of volitional lower limb muscle contractions or for weakness.…”

Section: ⅳ Discussionmentioning

confidence: 99%

The Effect of Gait Pattern in Hemiplegia Patients through Progressive Speed Increase Treadmill Training

Lee¹

2014

Journal of The Korean Society of Integrative Medicine

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Section: ⅳ Discussionmentioning

confidence: 99%

The Effect of Gait Pattern in Hemiplegia Patients through Progressive Speed Increase Treadmill Training

Lee¹

2014

Journal of The Korean Society of Integrative Medicine

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“…Since patients with SCIs often require intensive medical care, the cost of treatment is comparatively high. Trauma, coupled with treatment cost, is catastrophic for the patient, the patient's family and, indeed, all of society [5]. Owing to modern medical management, the survival rate and well-being of SCI patients have been substantially improved, yet the availability of medical treatments is still limited, with patients, in some cases, left with nothing but palliative and supportive care and the prospect of a lifelong disability.…”

Section: Introductionmentioning

confidence: 99%

Anp32a Promotes Neuronal Regeneration after Spinal Cord Injury of Zebrafish Embryos

Lai

Lin

Zeng³

et al. 2022

IJMS

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After spinal cord injury (SCI) in mammals, neuronal regeneration is limited; in contrast, such regeneration occurs quickly in zebrafish. Member A of the acidic nuclear phosphoprotein 32 (Anp32a) family is involved in neuronal development, but its function is controversial, and its involvement in zebrafish SCI remains unknown. To determine the role of zebrafish Anp32a in the neuronal regeneration of SCI embryos, we microinjected Anp32a mRNA into embryos from zebrafish transgenic line Tg(mnx1:GFP) prior to SCI. Compared to control SCI embryos, the results showed that the regeneration of spinal cord and resumption of swimming capability were promoted by the overexpression of Anp32a mRNA but reduced by its knockdown. We next combined fluorescence-activated cell sorting with immunochemical staining of anti-GFAP and immunofluorescence staining against anti-PH3 on Tg(gfap:GFP) SCI embryos. The results showed that Anp32a promoted the proliferation and cell number of radial glial cells at the injury epicenter at 24 h post-injury (hpi). Moreover, when we applied BrdU labeling to SCI embryos derived from crossing the Tg(gfap:GFP) and Tg(mnx1:TagRFP) lines, we found that both radial glial cells and motor neurons had proliferated, along with their increased cell numbers in Anp32a-overexpression SCI-embryos. On this basis, we conclude that Anp32a plays a positive role in the regeneration of zebrafish SCI embryos.

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“…People with an "incomplete" SCI have more potential to regain walking than those with a "complete" SCI which depends on many factors including Level of injury, severity of the injury, level of sensation, level of pain, time since injury, age, and level of fitness (3) . Other Related Problems such as Spasticity and Joint Problems e.g., Contractures It is difficult to predict if a person with SCI will regain walking abilities (4) . The proportion of patients with SCI who walked at inpatient discharge with devices/braces and without physical assistance: ASIA A (motor and sensory complete): 6.4%.…”

Section: Introductionmentioning

confidence: 99%

Role of Assistive Devices on Gait in Patients with Incomplete Spinal Cord Injury: Systematic Review

Alrefaie¹,

Salem²,

Fakharany³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: People with incomplete spinal cord injury disabilities can be able to live a healthy, productive, and dignified life by using Assistive devices as their role in improving gait. Facilitate locomotion rehabilitation. And enable people with incomplete SCI to ambulate in an upright position. Objective: This systematic review aimed to examine the effectiveness of the role of using assistive devices in gait rehabilitation in patients with incomplete SCI. Material and Methods: Studies were identified from 2000 to 2020 by electronic search using PubMed, Cochrane Database of Systematic Reviews, Google Scholar, and Physiotherapy Evidence Database (Pedro). They were reviewed if they were randomized control trials focused on the effectiveness of Assistive Devices on Gait in Patients in age more than 18 years with incomplete Spinal Cord Injury being published in English. Eight studies were selected according to inclusive and exclusive criteria and descriptive analysis was conducted due to heterogeneity. Results: Eight trials were identified with good quality methodology. Descriptive analysis was applied for three studies that supported the use of assistive devices for those patients and meta-analysis was applied for five studies. The mean difference across all the five studies is -0.69 (95% CI -0.93, -0.45). According to AACPDM, there is level II evidence that supports the use of the assistive device as a method to be able to live a healthy, productive, and dignified life. Conclusion: The current level of evidence supports the effectiveness of assistive devices in improving gait in patients with incomplete spinal cord injury.

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Traumatic spinal cord injury

Cited by 6 publications

References 157 publications

The Effect of Gait Pattern in Hemiplegia Patients through Progressive Speed Increase Treadmill Training

The Effect of Gait Pattern in Hemiplegia Patients through Progressive Speed Increase Treadmill Training

Anp32a Promotes Neuronal Regeneration after Spinal Cord Injury of Zebrafish Embryos

Role of Assistive Devices on Gait in Patients with Incomplete Spinal Cord Injury: Systematic Review

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