Traumatic shock in polytrauma: Circulatory parameters, biochemistry, and resuscitation

Meßmer, K.

doi:10.1007/bf01655909

Cited by 23 publications

(2 citation statements)

References 14 publications

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“…Furthermore, the same method evidenced a strong negative correlation between both parameters, SD, ΔT/Δx, and MAP. As widely known, sepsis and shock are characterized by an impaired blood flow to body tissues (hypoperfusion), which leads to temperature centralization [40], and commonly include hypotension [16]. Figure 7 demonstrates that the progress of the disease severity is accompanied by an increase in SD, ΔT/Δx and SI and a decrease in MAP.…”

Section: Discussionmentioning

confidence: 96%

Contact-free monitoring of circulation and perfusion dynamics based on the analysis of thermal imagery

Pereira¹,

Czaplik²,

Blanik³

et al. 2014

Biomed. Opt. Express

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Acute circulatory disorders are commonly associated with systemic inflammatory response (SIRS) and sepsis. During sepsis, microcirculatory perfusion is compromised leading to tissue hypoperfusion and potentially to multiple organ dysfunction. In the present study, acute lung injury (ALI), one of the major causes leading to SIRS and sepsis, was experimentally induced in six female pigs. To investigate the progress of body temperature distribution, measurements with a long-wave infrared camera were carried out. Temperature centralization was evidenced during ALI owing to impairments of peripheral perfusion. In addition, statistical analysis demonstrated strong correlations between (a) standard deviation of the skin temperature distribution (SD) and shock index (SI) (p<0.0005), (b) SD and mean arterial pressure (MAP) (p<0.0005), (c) ΔT/Δx and SI (p<0.0005), as well as between (d) ΔT/Δx and MAP (p<0.0005). For clarification purposes, ΔT/Δx is a parameter implemented to quantify the spatial temperature gradient. This pioneering study created promising results. It demonstrated the capacity of infrared thermography as well as of the indexes, SD and ΔT/Δx, to detect impairments in both circulation and tissue perfusion.

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Section: Discussionmentioning

confidence: 96%

Contact-free monitoring of circulation and perfusion dynamics based on the analysis of thermal imagery

Pereira¹,

Czaplik²,

Blanik³

et al. 2014

Biomed. Opt. Express

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“…Total serum protein concentrations are essential for the evaluation of protein catabolism in polytraumatized patients [33]. A reduction in total protein levels after severe trauma has been well described [4, 20].…”

Section: Discussionmentioning

confidence: 99%

Hematological and Chemical Profiles in a Porcine Model of Severe Multiple Trauma

et al. 2020

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Background: Clinical chemistry and hematological tests are widely used to monitor the clinical course of several diseases. However, these parameters are sparse in large-animal models of multiple trauma (MT). Thus, we aimed to provide these missing data to improve future experimental setups in trauma research. Methods: Male pigs (German Landrace pigs) were randomized into either an MT group (n = 8) including blunt thoracic trauma, tibial fracture, and controlled hemorrhage or a sham group (n = 8) without any trauma. After trauma induction, all animals received intensive care treatment for 72 h under anesthesia, including mechanical ventilation and volume resuscitation. Blood and urine samples were obtained to measure common hematological and chemical parameters before trauma (0 h), after trauma (1.5 h), during resuscitation (2.5 h), after fracture stabilization (3.5 h), and at 12, 24, 48, and 72 h. Statistical analyses were performed using a linear mixed model (group × time) and Welch’s ANOVA. Results: MT led to a perceptible immunological reaction. Between groups, significantly different time courses of leukocyte counts (p = 0.034) and lymphocyte proportions (p = 0.001) were observed. Moreover, MT changed the time course of total protein (p = 0.006). Significantly lower concentrations compared to sham were found in MT at each single time point starting at 1.5 h to the end of the observation period (all p < 0.05). Conclusions: Our results indicate that a traumatic insult leads to significant alterations in the immune system already shortly after trauma. Together with the additional catabolic reactions observed, these alterations might contribute to the occurrence of later complications. The presented data provide valid references for further experimental setups with prolonged observation times, especially in similar porcine models of MT.

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Schock und Traumareaktion

Meßmer

Frey

2006

Chirurgie

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Traumatic shock in polytrauma: Circulatory parameters, biochemistry, and resuscitation

Cited by 23 publications

References 14 publications

Contact-free monitoring of circulation and perfusion dynamics based on the analysis of thermal imagery

Contact-free monitoring of circulation and perfusion dynamics based on the analysis of thermal imagery

Hematological and Chemical Profiles in a Porcine Model of Severe Multiple Trauma

Schock und Traumareaktion

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