Traumatic neuroma: unusual benign lesion occurring in the mastectomy scar

Baltalarli, Bahar; Demirkan, Neşe Çallı; Yagci, Baki

doi:10.1016/j.clon.2004.07.007

Cited by 15 publications

(18 citation statements)

References 3 publications

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“…Previously reported traumatic neuromas after mastectomy usually occurred near the surgical site, most commonly in the lateral aspect of chest wall due to the high incidence of malignancies in this location [2-10]. In our study, five of the six traumatic neuromas were located in the upper outer aspect of the chest wall, and one was in the upper inner aspect.…”

Section: Discussionsupporting

confidence: 49%

“…They can occur in any part of the body that has been subjected to trauma or surgery, but most commonly occur in the lower extremities after amputation procedures, followed by the head and neck [2]. However, traumatic neuromas occurring in the breast or chest wall after surgery have been very rarely reported [2-10]. If a traumatic neuroma occurs in the breast or chest wall after oncologic surgery (breast-conserving surgery or mastectomy), it is difficult to clinically and radiologically differentiate from recurrence of the tumor, and a core needle biopsy or an excisional biopsy must be performed to obtain a pathologic diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…If a traumatic neuroma occurs in the breast or chest wall after oncologic surgery (breast-conserving surgery or mastectomy), it is difficult to clinically and radiologically differentiate from recurrence of the tumor, and a core needle biopsy or an excisional biopsy must be performed to obtain a pathologic diagnosis. To our knowledge, the imaging findings of traumatic neuroma in the breast or chest wall after surgery have only been described in 21 cases: 20 cases in six reports written in English [2,4,6,8-10], and one case report involving a Korean patient [5]. The majority of the articles were individual case reports.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic features of traumatic neuromas in breast cancer patients after mastectomy

Sung

Kim

2017

Ultrasonography

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PurposeThe purpose of this study was to evaluate the ultrasonographic (US) features of traumatic neuromas in breast cancer patients after mastectomy.MethodsThis study was performed with approval from our Institutional Review Board, and the requirement for informed consent was waived. Six traumatic neuromas in five patients were included in this study. The US findings of traumatic neuromas were evaluated retrospectively by two radiologists according to the Breast Imaging-Reporting and Data System (BI-RADS) lexicon. The final assessment was also recorded.ResultsOn US, all six lesions presented as a mass within the pectoralis muscle layer (mean size, 4.8 mm; range, 3.9 to 5.5 mm). Of the six masses, four had an oval shape with a circumscribed margin, and two had an irregular shape and an indistinct margin. They were all hypoechoic. Two lesions showed a non-parallel orientation. On color Doppler examinations, two lesions showed internal vascularity. Strain elastography was performed for four neuromas, resulting in scores of 1 (n=1), 4 (n=2), and 5 (n=1). The final assessment categories were BI-RADS 3 (n=2), 4A (n=2), and 4B (n=2).ConclusionOn US, an oval shape, circumscribed margin, parallel orientation, and hypoechogenicity were the most frequent features of traumatic neuromas in breast cancer patients after mastectomy. Neuromas may show increased vascularity on color Doppler imaging and present as a hard mass on elastography.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ultrasonographic features of traumatic neuromas in breast cancer patients after mastectomy

Sung

Kim

2017

Ultrasonography

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“…There were two published cases found of traumatic neuromas, which resembled granular cell tumors at mastectomy scars [7] . Additionally, a case report on traumatic neuromas occurring 2 years post-mastectomy showed that ultrasonographic examination and axial computed tomography imaging may help in a differential diagnosis from recurrence cancer [8] . Ultrasonography showed a well-circumscribed, homogeneous, hypoechoic subcutaneous nodular lesion [9] .…”

Section: Discussionmentioning

confidence: 99%

Traumatic neuromas in breast cancer patients after mastectomy

Wang

Cao

Ning

2007

Chin. J. Clin. Oncol.

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OBJECTIVE Traumatic neuromas are rare benign lesions occurring post-mastectomy, which are usually suspected as tumour recurrences before excision biopsy. We report six cases presenting with palpable nodules postmastectomy, to emphasize the differential diagnosis of traumatic neuroma from recurrent cancer. METHODS Six cases were reviewed. The age of patients ranged from 33 to 61 years. Nodular masses were found close to the mastectomy scar during follow-up over a period of 2.8 to 8 years. RESULTS In one patient three nodular masses were detected. Five patients had received chemotherapy, three of which had also received radiotherapy. Ultrasound examinations showed a well-circumscribed, homogeneous, hypo-echoic subcutaneous nodular lesion in four cases, and a poorly defined hypo-echoic nodule with good conduction in two cases. No obvious distant metastases had been identified. Each patient underwent surgical excisional biopsy. All of nodules had a diameter less than 1 cm. Histopathological examination showed proliferation of nerve fibre bundles, which were disordered, oriented and well circumscribed in fibro-adipose tissue. CONCLUSION It was concluded that all of the lesions were traumatic neuromas, independent from the initial tumor. Traumatic neuromas occurring in mastectomy scars are difficult to distinguish from a tumor recurrence. Although radiological evaluation of the mass with ultrasound is of value, the diagnosis can only be confirmed following a histopathological evaluation.

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“…There were two published reports found on traumatic neuromas that resembled granular cell tumours at mastectomy scars 4 . Additionally, a case report on traumatic neuromas occurring 2 years post‐mastectomy showed that ultrasonographic examination and axial computed tomography images may help in the differential diagnosis of recurrent cancer 5 …”

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confidence: 99%