Traumatic injury to peripheral nerves

Robinson, Lawrence R.

doi:10.1002/mus.27706

Cited by 35 publications

(31 citation statements)

References 73 publications

(150 reference statements)

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“…15 The type of nerve injury was classified according to the Seddon classification. 16 Neurotmesis (n = 40) and axonotmesis (n = 58) were the most common nerve injuries encountered.…”

Section: Resultsmentioning

confidence: 99%

Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review

ElAbd

Alabdulkarim

Al-Sabah

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Background: Functional recovery after peripheral nerve injury is often suboptimal despite the intrinsic permissive growth environment of the peripheral nervous system. The objective of this systematic review is to explore the use of electrical stimulation (ES) for peripheral nerve regeneration. Methods: A systematic literature search was conducted from inception to March 2, 2021 to retrieve articles on ES for peripheral nerve regeneration using the PubMed, Ovid MEDLINE, and Embase databases. Primary outcome measures included objective measures of motor and sensory nerve function. Results: Four randomized control trials, two case reports, and three case series that addressed the aims were identified. The stimulation parameters varied greatly between studies, without an apparent commonality for a given electrical conduit.Outcomes measured included motor (n = 8) and sensory (n = 7) modalities (cold detection, static two-point discrimination, tactile discrimination, and pressure detection), nerve-specific muscle function and bulk, and electromyography (EMG) motor and sensory terminal latency. Different parameters for measurement were utilized and improvement was observed across the studies compared with controls (n = 4) or pre-intervention measurements (n = 5). One randomized control trial reported no benefit of ES and attributed their findings to their stimulation protocol. Complications were documented in three patients only and included wire remnant removal, skin pigmentation, and bone formation. Conclusions: ES in peripheral nerve regeneration is beneficial in improving and accelerating recovery. A meta-analysis was not performed due to the heterogeneity, but all studies showed positive findings and minor to no complications. These results provide a primer for further development of delivery methods.

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“…15 The type of nerve injury was classified according to the Seddon classification. 16 Neurotmesis (n = 40) and axonotmesis (n = 58) were the most common nerve injuries encountered.…”

Section: Resultsmentioning

confidence: 99%

Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review

ElAbd

Alabdulkarim

Al-Sabah

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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“…42 It is estimated that roughly 2 to 3% of all patients admitted to level-I trauma centers have peripheral nerve injuries. 43 44 45 Peripheral nerve injuries resulting from trauma often require surgical intervention to repair the injured nerves. Certain methods of peripheral nerve repair involve intentional peripheral nerve injury, such as nerve transfers or autologous nerve grafting.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Collagen and Human Amniotic Membrane Nerve Wraps and Conduits for Peripheral Nerve Repair in Preclinical Models: A Systematic Review of the Literature

Wolfe

Mathis

Ovadia

et al. 2022

J Reconstr Microsurg

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Introduction Collagen and human amniotic membrane (hAM) are Food and Drug Administration (FDA)-approved biomaterials that can be used as nerve wraps or conduits for repair of peripheral nerve injuries. Both biomaterials have been shown to reduce scarring and fibrosis of injured peripheral nerves. However, comparative advantages and disadvantages have not been definitively shown in the literature. The purpose of this systematic review is to comprehensively evaluate the literature regarding the roles of hAM and collagen nerve wraps and conduits on peripheral nerve regeneration in preclinical models. Methods The MEDLINE database was queried using the PubMed search engine on July 7, 2019, with the following search strategy: (“amniotic membrane” OR “amnion”) OR (“collagen conduit” OR “nerve wrap”)] AND “nerve.” All resulting articles were screened by two independent reviewers. Nerve type, lesion type/injury model, repair type, treatment, and outcomes were assessed. Results Two hundred and fifty-eight articles were identified, and 44 studies remained after application of inclusion and exclusion criteria. Seventeen studies utilized hAM, whereas 27 studies utilized collagen wraps or conduits. Twenty-three (85%) of the collagen studies utilized conduits, and four (15%) utilized wraps. Six (35%) of the hAM studies utilized conduits and 11 (65%) utilized wraps. Two (9%) collagen studies involving a conduit and one (25%) involving a wrap demonstrated at least one significant improvement in outcomes compared with a control. While none of the hAM conduit studies showed significant improvements, eight (73%) of the studies investigating hAM wraps showed at least one significant improvement in outcomes. Conclusion The majority of studies reported positive outcomes, indicating that collagen and hAM nerve wraps and conduits both have the potential to enhance peripheral nerve regeneration. However, relatively few studies reported significant findings, except for studies evaluating hAM wraps. Preclinical models may help guide clinical practice regarding applications of these biomaterials in peripheral nerve repair.

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“…Peripheral nerve injury (PNI) is a prevalent clinical concern, presenting in approximately 5% of patients with trauma associated with nerve root and brachial plexus injuries ( Noble et al, 1998 ; Robinson, 2022 ). Although the peripheral nervous system (PNS) is capable of autonomous healing through peripheral nerve regeneration (PNR), the likelihood of complete nerve regrowth following an injury depends, in part, on the injury grade and gap size between the proximal and distal ends of the injured nerve ( Lundborg et al, 1982 ; Menorca et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration

Izhiman,

Esfandiari

2024

Front. Cell. Neurosci.

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Peripheral nerve injuries lead to significant morbidity and adversely affect quality of life. The peripheral nervous system harbors the unique trait of autonomous regeneration; however, achieving successful regeneration remains uncertain. Research continues to augment and expedite successful peripheral nerve recovery, offering promising strategies for promoting peripheral nerve regeneration (PNR). These include leveraging extracellular vesicle (EV) communication and harnessing cellular activation through electrical and mechanical stimulation. Small extracellular vesicles (sEVs), 30–150 nm in diameter, play a pivotal role in regulating intercellular communication within the regenerative cascade, specifically among nerve cells, Schwann cells, macrophages, and fibroblasts. Furthermore, the utilization of exogenous stimuli, including electrical stimulation (ES), ultrasound stimulation (US), and extracorporeal shock wave therapy (ESWT), offers remarkable advantages in accelerating and augmenting PNR. Moreover, the application of mechanical and electrical stimuli can potentially affect the biogenesis and secretion of sEVs, consequently leading to potential improvements in PNR. In this review article, we comprehensively delve into the intricacies of cell-to-cell communication facilitated by sEVs and the key regulatory signaling pathways governing PNR. Additionally, we investigated the broad-ranging impacts of ES, US, and ESWT on PNR.

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Traumatic injury to peripheral nerves

Cited by 35 publications

References 73 publications

Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review

Role of Electrical Stimulation in Peripheral Nerve Regeneration: A Systematic Review

Comparison of Collagen and Human Amniotic Membrane Nerve Wraps and Conduits for Peripheral Nerve Repair in Preclinical Models: A Systematic Review of the Literature

Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration

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