Traumatic facial nerve paralysis dilemma. Decision making and the novel role of endoscope

Elkahwagi, Mohamed; Salem, Mohamed A.; Moneir, Waleed; Allam, Hassan

doi:10.1016/j.joto.2022.03.003

Cited by 3 publications

(5 citation statements)

References 26 publications

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“…36,47 No molecular tools are available for immediate and precise assessment of at-risk vital nerves, 48 which, once damaged, might negatively impact a patient's quality of life. 49 In 2019, we reported a proof-of-principle tracer for in vivo labeling of the peripheral nervous system in mice, 38 but a nearinfrared multimodal nerve imaging agent has not yet been reported. Such an agent would be clinically useful insofar as it would allow physicians to rapidly assess the magnitude of potential nerve trauma: PET/CT could provide rapid assessment of nerve damage using the radiolabeled part of the conjugate.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Identifying the small nerves surrounding those tumors is also of utmost importance when considering post-operative functional outcomes. Currently, small nerve identification relies heavily on visual observation, tactual exploration by the surgeon, and subjective patient feedback. , No molecular tools are available for immediate and precise assessment of at-risk vital nerves, which, once damaged, might negatively impact a patient’s quality of life …”

Section: Discussionmentioning

confidence: 99%

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Development and Validation of Nerve-Targeted Bacteriochlorin Sensors

Hernández-Gil,

Chow,

Chatras

et al. 2023

J. Am. Chem. Soc.

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We report an innovative approach to producing bacteriochlorins (bacs) via formal cycloaddition by subjecting a porphyrin to a trimolecular reaction. Bacs are near-infrared probes with the intrinsic ability to serve in multimodal imaging. However, despite their ability to fluoresce and chelate metal ions, existing bacs have thus offered limited ability to label biomolecules for target specificity or have lacked chemical purity, limiting their use in bio-imaging. In this work, bacs allowed a precise and controlled appending of clickable linkers, lending the porphyrinoids substantially more chemical stability, clickability, and solubility, rendering them more suitable for preclinical investigation. Our bac probes enable the targeted use of biomolecules in fluorescence imaging and Cerenkov luminescence for guided intraoperative imaging. Bacs’ capacity for chelation provides opportunities for use in non-invasive positron emission tomography/computed tomography. Herein, we report the labeling of bacs with Hs1a, a (NaV1.7)-sodium-channel-binding peptide derived from the Chinese tarantula Cyriopagopus schmidti to yield Bac-Hs1a and radiolabeled Hs1a, which shuttles our bac sensor(s) to mouse nerves. In vivo, the bac sensor allowed us to observe high signal-to-background ratios in the nerves of animals injected with fluorescent Bac-Hs1a and radiolabeled Hs1a in all imaging modes. This study demonstrates that Bac-Hs1a and [64Cu]Cu-Bac-Hs1a accumulate in peripheral nerves, providing contrast and utility in the preclinical space. For the chemistry and bio-imaging fields, this study represents an exciting starting point for the modular manipulation of bacs, their development and use as probes for diagnosis, and their deployment as formidable multiplex nerve-imaging agents for use in routine imaging experiments.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development and Validation of Nerve-Targeted Bacteriochlorin Sensors

Hernández-Gil,

Chow,

Chatras

et al. 2023

J. Am. Chem. Soc.

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“…Kasus PTDK bagian tengah paling sering terjadi di bagian petrosa tulang temporal dan sebanyak 7-10% terjadi kerusakan saraf fasialis yaitu saraf kranial ketujuh (N.VII) perifer pada fraktur dasar tulang tengkorak bagian tengah. 9 Tulang temporal dibentuk oleh lima bagian, yaitu, skuama sebagai dinding lateral, mastoid, petrosa, timpani dan stiloid. Klasifikasi fraktur tulang temporal menjadi tiga, yaitu: fraktur longitudinal, transversal dan gabungan.…”

Section: Pendahuluanunclassified

Patomekanisme dan Insidensi Cedera Saraf Fasialis Perifer akibat Fraktur Dasar Kepala Tengah

Putri¹,

Prasetyo²,

Wagiu³

2023

MSJ

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Skull base fracture (SBF) was defined as a fracture implicating the base of the skull, and was divided into three types, namely: anterior, media, and posterior cranial base fractures. SBF could cause serious complications, and occurs mostly in the middle and anterior sections. This study aimed to determine the pathomechanism and incidence of facial nerve injury in patients with fractures of the middle skull base. This was a literature review study. The results obtained 14 journals that fulfilled the criteria. The incidence of mid-section SBF causing facial nerve injuries was 3.25% to 8%. Age was related to the mechanism of SBF. In adults and elderly, most SBF were caused by accidents. Facial nerve paralysis due to transverse fracture was more serious and often required surgical treatment. The most frequent onset of facial nerve paralysis was immediate paralysis. Longitudinal fracture had better recovery compared to transverse or mixed fractures. In conclusion, the incidence of mid-section SBF causing facial nerve injuries was 3.25% to 8%. SBF involving facial nerve injury was more prevalent in longitudinal fractures with labyrinth bone involvement in the inner ear; however, it has better recovery than transverse or mixed fractures. Keywords: skull base fracture; temporal bone fracture; facial nerve paralysis Abstrak: Patah tulang dasar kepala (PTDK) didefinisikan sebagai fraktur yang melibatkan dasar tengkorak. Terdapat tiga jenis PTDK, yaitu: fraktur basis kranii anterior, media, dan posterior. PTDK dapat menyebabkan komplikasi serius dan paling banyak terjadi pada fraktur bagian tengah dan anterior. Penelitian ini bertujuan untuk mengetahui patomekanisme dan insiden cedera saraf fasialis (saraf kranial ketujuh) perifer pada penderita PTDK bagian tengah. Jenis penelitian ialah suatu literatur review. Hasil penelitian mendapatkan 14 jurnal yang sesuai dengan topik. Insiden PTDK bagian tengah yang menyebabkan cedera saraf fasialis sebesar 3,25%-8%. Usia berkaitan dengan mekanisme utama penyebab terjadinya PTDK, yaitu pada kalangan dewasa dan lansia sebagian besar disebabkan oleh kecelakaan. Kelumpuhan saraf fasialis pada fraktur transversal lebih serius dan sering membutuhkan perawatan bedah. Onset kelumpuhan saraf fasialis yang paling sering ialah kelumpuhan segera. Fraktur longitudinal memiliki pemulihan yang lebih baik dibandingkan dengan fraktur transversal atau campuran. Simpulan penelitian ini ialah insidensi PTDK bagian tengah yang menyebabkan cedera saraf fasialis sebesar 3,25%-8%. PTDK bagian tengah yang melibatkan cedera saraf fasialis paling banyak terjadi pada fraktur longitudinal dengan keterlibatan tulang labirin pada telinga bagian dalam namun dengan pemulihan yang lebih baik dibandingkan fraktur transversal atau campuran. Kata kunci: patah tulang dasar kepala; fraktur tulang temporal; kelumpuhan saraf fasialis perifer

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“…This development recently proposed the transcanal endoscopic facial nerve surgery for the treatment of facial nerve diseases located on its tympanic segment and geniculate ganglion (GG) [48]. The clinical role of TEA in management of cases with posttraumatic facial nerve paralysis has been clinically published in the past few years [49,50]. This approach offered the most direct and least invasive approach for the most commonly affected nerve segments by the trauma and spared the normal mastoid tissue with avoidance of the external incision [50] (Fig.…”

Section: Ees In Neurotologymentioning

confidence: 99%

“…The clinical role of TEA in management of cases with posttraumatic facial nerve paralysis has been clinically published in the past few years [49,50]. This approach offered the most direct and least invasive approach for the most commonly affected nerve segments by the trauma and spared the normal mastoid tissue with avoidance of the external incision [50] (Fig. 7).…”

Section: Ees In Neurotologymentioning

confidence: 99%

Endoscopic ear surgery: then and now, review article

Moneir

Elkahwagi

2022

Egypt J Otolaryngol

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Objective Endoscopic ear surgery (EES) is a growing and well-recognized field in the modern era. EES had a stepwise journey of development. This journey is pretty comparable to the endoscopic sinus surgery development. Methods Online literature search was performed to give a concise review on the development and recent applications of EES and in addition to clarify the reported advantages and disadvantages of EES. Results EES has a more recent application than ESS that started decades after endoscopic sinus surgery (ESS). The use of endoscope in ear surgery gives a wide-angled detailed view of the middle ear structures. It gives the ability to look around the corners offering less disease persistence than the microscopic approaches. EES is useful in cases of narrow and angled external auditory canal as it bypasses the narrowest segment of EAC. However, it lacks the 3D perception and enables one hand surgery which could be difficult to manage bleeding. Applications of EES extended from tympanoplasty, stapedotomy, cholesteatoma surgery, and middle ear ventilation in chronic inflammatory conditions to the neurotologic applications in lateral skull base surgery. Conclusion EES is an extremely growing field with many applications in otology and neurotology. The advantages of endoscopic applications outweigh the disadvantages. It has a stepwise learning curve and offer better teaching ability.

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Traumatic facial nerve paralysis dilemma. Decision making and the novel role of endoscope

Cited by 3 publications

References 26 publications

Development and Validation of Nerve-Targeted Bacteriochlorin Sensors

Development and Validation of Nerve-Targeted Bacteriochlorin Sensors

Patomekanisme dan Insidensi Cedera Saraf Fasialis Perifer akibat Fraktur Dasar Kepala Tengah

Endoscopic ear surgery: then and now, review article

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