Traumatic Experiences in Childhood and Adult Substance Use in a Nonclinical Sample: The Mediating Role of Arousal/Reactivity

Love, Heather A.; Torgerson, Chelsey N.

doi:10.1111/jmft.12348

Cited by 8 publications

(6 citation statements)

References 55 publications

(78 reference statements)

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“…Similarly, an evaluation of justice-involved youth found PTSD symptomatology was not only associated with SUD symptoms, but it may also mediate the association between SUD symptoms and externalizing behaviors [ 56 ]. Further, decreasing hyperarousal and impulsivity may be vital to reducing problematic substance use [ 57 ].…”

Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Hinckley

Danielson

2022

Brain Sciences

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Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress disorder (PTSD) and SUD, and these comorbid disorders exhibit high levels of overlapping symptomatology. Theoretical models proposed to explain the bidirectional relationship between PTSD and SUD include the self-medication hypothesis and susceptibility hypothesis. In this article, we explore neurobiologic changes associated with trauma, PTSD, and SUD that underly dysregulated stress response. Examining lessons learned from recent translational and clinical research, we propose that further elucidating the neurobiologic etiology of comorbid PTSD and SUD will require a collaborative, interdisciplinary approach, including the integration of preclinical and clinical studies, exploration of biologic markers in clinical studies, and accumulation of larger studies and longitudinal studies with the power to study PTSD and SUD. Such research can transform the field and ultimately reduce high rates and costly impairment of co-occurring PTSD and SUD across the lifespan.

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Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Hinckley

Danielson

2022

Brain Sciences

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“…Alcohol abuse is 6–12 times more common among patients who suffered physical abuse in childhood than among those who did not [ 13 ]. Childhood trauma may lead to alcohol use disorder in adulthood through mechanisms based on post-traumatic stress or with the goal of “self-medication” [ 14 – 17 ]. Under the influence of physical and mental post-traumatic symptoms, patients may become socially maladjusted, coping unproductively with negative events and suffering distortions in cognition and personality.…”

Section: Introductionmentioning

confidence: 99%

Family alcohol use, rather than childhood trauma, is more likely to cause male alcohol use disorder: findings from a case-control study in northern China

Chen

Pan²,

et al. 2021

BMC Psychiatry

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Objective To explore the influence of childhood trauma and family alcohol use on male alcohol use disorder. Methods We conducted a case-control study using Childhood Trauma Questionnaire (CTQ) and a structured interview involving 129 men with alcohol use disorder and 129 healthy male volunteers. The two groups were compared in terms of childhood trauma, parental drinking behavior, and attitudes toward childhood drinking. Results Patients showed higher scores of CTQ than controls on childhood trauma experiences, including on the subscales of physical abuse, emotional abuse, sexual abuse, and emotional neglect. Higher proportions of patients than controls had fathers who drank seven or more times a week, and had mothers who were opposed to childhood drinking. Conversely, a smaller proportion of patients than controls had fathers who opposed childhood drinking. Patients were more likely than controls to have been induced to drink as children. Logistic regression analysis identified three risk factors for alcohol use disorder: induced drinking during childhood [odds ratio (OR) 6.09, 95% confidence interval (CI) 2.56–14.51], the father’s weekly alcohol consumption during the respondent’s childhood (OR 4.40, 95%CI 2.94–6.58) and history of smoking (OR 3.39, 95%CI 1.48–7.77). Conversely, more years of education were a protective factor against alcohol use disorder (OR 0.88, 95% CI 0.78–0.99). Conclusions Men whose fathers drank frequently during their childhood and were encouraged to drink may be at increased risk of alcohol use disorder in adulthood. In fact these factors of family alcohol use appear to increase risk of alcohol use disorder among adult men more than exposure to childhood trauma does.

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“…In the United States, the majority of children encounter one or more forms of trauma, and it is estimated that 90% of people endure at least one traumatic event during their life [22,26]. Those who face adverse childhood experiences (ACE) have an increased likelihood of lifetime substance use disorders and a higher risk for alcoholism, depressed affect, post-traumatic stress disorder (PTSD), and illicit drug use [12,26].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Childhood Trauma on Drug Use

Ranasinghe¹,

Amarasinghe²,

Lash³

2020

CMRR

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Exposure to childhood physical abuse, sexual abuse, emotional abuse, and neglect have been found to have a positive association with drug use. Various studies have demonstrated how individuals may turn to drugs as a form of coping. However, this is a negative form of coping, which can take a toll on one’s mental state and even impact families and society. Studies have reported that a higher number of adverse childhood experiences (ACEs) have a stronger association with substance use later in life [1,3]. Recent research has also demonstrated those who experienced childhood neglect also displayed anxiety or depression, which might suggest a reason for the connection between the negligence and drug use [14]. There is also research that shows that childhood maltreatment could influence one’s susceptibility to drugs and the structural remodeling of the brain [4]. Various types of drugs have been used in association with childhood trauma; however, no single drug was reported to have a greater association than the others. Substance abuse has been a rising issue over the years. With the understanding that childhood trauma could contribute to the onset of drug use, it is essential to gain a better knowledge of the specific types of substance abuse linked to childhood trauma. Future examination of this topic can help raise awareness and educate society on the effects of childhood trauma and how to prevent drug use associated with it.

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Traumatic Experiences in Childhood and Adult Substance Use in a Nonclinical Sample: The Mediating Role of Arousal/Reactivity

Cited by 8 publications

References 55 publications

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Family alcohol use, rather than childhood trauma, is more likely to cause male alcohol use disorder: findings from a case-control study in northern China

The Effects of Childhood Trauma on Drug Use

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