Traumatic brain injury (TBI) in older adults: aging with a TBI versus incident TBI in the aged

Peters, Matthew E.

doi:10.1017/s1041610216001666

Cited by 25 publications

(21 citation statements)

References 21 publications

(33 reference statements)

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“…The prevalence in World Trade Center responders is 12.8% or 33,000 persons who are at risk for dementia as they age. CDC has estimated that across the lifespan 5.3 million older Americans are living with TBI …”

Section: Alzheimer's Disease Overviewmentioning

confidence: 99%

“…However, it has also showed that this causality is not linear, being rather more complex and involving multiple causes . Recent advances on the understanding of Alzheimer's disease genetics and molecular pathways have helped identifying novel cerebrospinal fluid and blood biomarkers, as well as the development of promising new therapies that are currently being tested . Among the promising therapies, are those which target Aβ production, direct targeting of Aβ and tau, and immunotherapy .…”

Section: Research and Future Directionsmentioning

confidence: 99%

“…CDC has estimated that across the lifespan 5.3 million older Americans are living with TBI. 31 Furthermore, lifestyle-related risk factors for Alzheimer's disease (diabetes, hypertension, obesity, physical inactivity, depression, smoking, and low educational attainment) have also been implicated. 32 These are modifiable risk factors that might account for about a third of patients with Alzheimer's disease worldwide, thus there is hope for a substantial reduction in patients with dementia if these factors can be reduced or eliminated.…”

Section: Etiologymentioning

confidence: 99%

“…4,75 Recent advances on the understanding of Alzheimer's disease genetics and molecular pathways have helped identifying novel cerebrospinal fluid and blood biomarkers, 4,37,76 as well as the development of promising new therapies that are currently being tested. 31,66 Among the promising therapies, are those which target A production, direct targeting of A and tau, and immunotherapy. 37,76 Traditional preventive therapies, which improve brain circulation are still used to target Alzheimer's disease.…”

Section: What Are the Most Promising Strategies?mentioning

confidence: 99%

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Oral health care for patients with Alzheimer's disease: An update

Marchini

Ettinger

Caprio

et al. 2019

Special Care in Dentistry

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Alzheimer's disease and related disorders (ADRD) are among the age‐associated chronic conditions that are most challenging to health care systems around the globe, as patients with dementia require full‐time, intensive care for multiple years. Oral health care is negatively impacted by cognitive decline, and consequently poor oral health is common among people with ADRD. Poor oral health status is linked with many undesirable consequences for the well‐being of people with ADRD, from excruciating local pain to life‐threatening conditions, as aspiration pneumonia. In this paper, the authors provide an update on the most current concepts about Alzheimer's disease epidemiology, etiology, and management, current oral health care for patients with Alzheimer's disease, oral health promotion strategies for this population, as well as current research and future direction for improving oral health care for patients with Alzheimer's disease. It concludes that oral health care should be included in the patient's routine health care as early as possible in the progression of Alzheimer's disease for preventing rapid oral health deterioration. Establishing oral hygiene routines and providing dental treatment that is customized to the patients’ individual needs and disease stage are important to achieve good oral health outcomes and prevent quality of life decline.

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Section: Alzheimer's Disease Overviewmentioning

confidence: 99%

Section: Research and Future Directionsmentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

Section: What Are the Most Promising Strategies?mentioning

confidence: 99%

See 2 more Smart Citations

Oral health care for patients with Alzheimer's disease: An update

Marchini

Ettinger

Caprio

et al. 2019

Special Care in Dentistry

View full text Add to dashboard Cite

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“…Most likely, her injury during childhood began a degenerative process sufficient to culminate in cognitive decline and MCI in later adulthood. Our examination will be of particular interest to those assessing the clinical importance of patients who are “aging after having suffered TBI” in contradistinction to those who experience “incidents of TBI during aging” (Peters, ).…”

Section: Discussionmentioning

confidence: 99%

Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury

Horn

Irimia

Torgerson

et al. 2017

J of Neuroscience Research

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In this report, we present a case study involving an older, female patient with a history of pediatric TBI. Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared to corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). Our analyses find the patient’s brain morphometry and connectivity most similar to patients classified as having early-onset MCI, in contrast to HC, late MCI, and AD samples. Our examination will be of particular interest to those interested in assessing the clinical course in older patients having suffered TBI earlier in life, in contradistinction to those which experience incidents of head injury during aging.

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Incidence of chronic subdural haematoma: a single-centre exploration of the effects of an ageing population with a review of the literature

et al. 2021

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Background Chronic subdural haematoma (cSDH) is a common neurosurgical pathology frequently occurring in older patients. The impact of population ageing on cSDH caseload has not been examined, despite relevance for health system planning. Methods This is a single-centre study from the UK. Operated cases of cSDH (n = 446) for 2015–2018 were identified. Crude and directly standardised incidence rates were calculated. Medline and EMBASE were systematically searched to identify studies reporting on the incidence of cSDH by year, so an estimate of rate of incidence change could be determined. Local incidence rates were then applied to population projections for local catchment area to estimate operated cSDH numbers at 5 yearly intervals due to shifting demographics. Results We identified nine studies presenting incidence estimates. Crude estimates for operative cases ranged from 1.3/100,000/year (1.4–2.2) to 5.3/100,000/year (4.3–6.6). When non-operated cases were included, incidence was higher: 8.2/100,000/year (6.0–11.2) to 48/100,000/year (37.7–61.1). Four pairs of studies demonstrated incidence rate increases of 200–600% over the last 50 years, but data was deemed too heterogeneous to generate formal estimate of incidence change. Local crude incidence of operated cSDH was 3.50/100,000/year (3.19–3.85). Directly standardised incidence was 1.58/100,000/year (1.26–1.90). After applying local incidence rates to population projections, case numbers were predicted to increase by 53% over the next 20 years. Conclusions The incidence of cSDH is increasing. We project a 53% increase in operative caseload within our region by 2040. These are important findings for guiding future healthcare planning.

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Traumatic brain injury (TBI) in older adults: aging with a TBI versus incident TBI in the aged

Cited by 25 publications

References 21 publications

Oral health care for patients with Alzheimer's disease: An update

Oral health care for patients with Alzheimer's disease: An update

Mild cognitive impairment and structural brain abnormalities in a sexagenarian with a history of childhood traumatic brain injury

Incidence of chronic subdural haematoma: a single-centre exploration of the effects of an ageing population with a review of the literature

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